Such a huge congratulations to the team🥳

Remember, you can find the full article here 🔗bit.ly/49syndi

#epigenetics #DNAmethylation

🧵6/6

Key Takeaways🔑:

✨EpiAnceR+ improves ancestry adjustment when genotyping data aren’t available

✨and is compatible with all major Illumina methylation arrays

🧵5/6

Results📊:

✨EpiAnceR+ improved on existing methods✨

Its ancestry PCs:

1⃣clustered repeated samples more tightly,

2⃣correlated more strongly with true genetic ancestry,

3⃣and outperformed methylation-based PCs and surrogate variables for ancestry correction

🧵4/6

Methods🗒️:

To address this, the team developed EpiAnceR+🧑🏾‍💻,

an R-based tool for ancestry adjustment in DNA methylation studies🧬

Function:

1⃣removes technical and biological noise, integrates SNP-related data

2⃣and generates ancestry PCs for downstream analysis

🧵3/6

Background❓:

🧬Genetic ancestry can confound DNA methylation results

🧬When genotyping data aren’t available, existing ancestry-adjustment methods often:

1⃣perform suboptimally,

2⃣or aren’t compatible with newer methylation arrays

🧵2/6

Watch the video📽️attached to see what each of these awesome #FemsinSTEM are up to!

🧵3/3

The FG PGC is proud to have✨4 out of the 7✨leadership roles held by women.

These fearless fem leaders include @janitzamontalvo.bsky.social , @hyejungwon.bsky.social sky.social, Xueyi Shen, and of course, our wonderful co-chair, @maryellenlynall.bsky.social

🧵2/3

Full link here🔗www.nature.com/articles/s41467-024-55611-1

Huge congrats to the team!!🥳

To find out more about who we are and how YOU can be involved, check out our intro video, and the website link below!⬇️⬇️
pgc.unc.edu/for-research...

#science #Genetics #PsychiatricGenetics