Yi Feng
@fengfishlab.bsky.social
Want to prevent cancer through research, if I persist we may get there in the end or at least I will learn something along the way. Zebrafish lab in Edinburgh study tumour initiation. Favourite cell is neutrophils. I❤️fish! I paint to relax 🎨
Reposted by Yi Feng
For those interested, we’ve got two #WomenInScience lists, a list of resource and society accounts that support #zebrafish and lists of Senior Scientists & Group Leaders that work with our favorite fish. If you’re not on a list and want to be added (or just want to double-check), please reach out! 🧪
Inject some #zebrafish into your timeline with our updated Starter Packs! 🧪
WomenInScience v1: go.bsky.app/4BegEjv
"" v2: go.bsky.app/VoebYrt
Resources: go.bsky.app/JcC5df3
Sr. Scientists & PIs v1: go.bsky.app/2cHYybY
"" v2: go.bsky.app/4zBuxAF
"" v3: go.bsky.app/JvjuSZg
"" v4: go.bsky.app/2c4WLQK
WomenInScience v1: go.bsky.app/4BegEjv
"" v2: go.bsky.app/VoebYrt
Resources: go.bsky.app/JcC5df3
Sr. Scientists & PIs v1: go.bsky.app/2cHYybY
"" v2: go.bsky.app/4zBuxAF
"" v3: go.bsky.app/JvjuSZg
"" v4: go.bsky.app/2c4WLQK
November 1, 2025 at 7:43 PM
For those interested, we’ve got two #WomenInScience lists, a list of resource and society accounts that support #zebrafish and lists of Senior Scientists & Group Leaders that work with our favorite fish. If you’re not on a list and want to be added (or just want to double-check), please reach out! 🧪
Reposted by Yi Feng
However long I live here I will never get used to how utterly beautiful the views from Princes St are. This was last night 😍
November 2, 2025 at 9:59 AM
However long I live here I will never get used to how utterly beautiful the views from Princes St are. This was last night 😍
Reposted by Yi Feng
Inject some #zebrafish into your timeline with our updated Starter Packs! 🧪
WomenInScience v1: go.bsky.app/4BegEjv
"" v2: go.bsky.app/VoebYrt
Resources: go.bsky.app/JcC5df3
Sr. Scientists & PIs v1: go.bsky.app/2cHYybY
"" v2: go.bsky.app/4zBuxAF
"" v3: go.bsky.app/JvjuSZg
"" v4: go.bsky.app/2c4WLQK
WomenInScience v1: go.bsky.app/4BegEjv
"" v2: go.bsky.app/VoebYrt
Resources: go.bsky.app/JcC5df3
Sr. Scientists & PIs v1: go.bsky.app/2cHYybY
"" v2: go.bsky.app/4zBuxAF
"" v3: go.bsky.app/JvjuSZg
"" v4: go.bsky.app/2c4WLQK
November 1, 2025 at 8:09 AM
Inject some #zebrafish into your timeline with our updated Starter Packs! 🧪
WomenInScience v1: go.bsky.app/4BegEjv
"" v2: go.bsky.app/VoebYrt
Resources: go.bsky.app/JcC5df3
Sr. Scientists & PIs v1: go.bsky.app/2cHYybY
"" v2: go.bsky.app/4zBuxAF
"" v3: go.bsky.app/JvjuSZg
"" v4: go.bsky.app/2c4WLQK
WomenInScience v1: go.bsky.app/4BegEjv
"" v2: go.bsky.app/VoebYrt
Resources: go.bsky.app/JcC5df3
Sr. Scientists & PIs v1: go.bsky.app/2cHYybY
"" v2: go.bsky.app/4zBuxAF
"" v3: go.bsky.app/JvjuSZg
"" v4: go.bsky.app/2c4WLQK
Reposted by Yi Feng
The first international workshop that focused on #zebrafish was convened in 1990 in Eugene, Oregon. Sponsored by NIH and NSF, the gathering of ∼40 scientists sought to evaluate the research potential of the tiny fish. Today, nearly 1,800+ zebrafish labs exist worldwide. #ZebrafishFunFacts 🧪
November 1, 2025 at 12:00 PM
The first international workshop that focused on #zebrafish was convened in 1990 in Eugene, Oregon. Sponsored by NIH and NSF, the gathering of ∼40 scientists sought to evaluate the research potential of the tiny fish. Today, nearly 1,800+ zebrafish labs exist worldwide. #ZebrafishFunFacts 🧪
Hot off the press, after years of work by many PG and undergrads and collaborators, we present you wilth a detailed analysis of oncogenic RAS driven cellular plasticity and host immune response within 24 hours of oncogene activation in a #zebrafish model www.cell.com/cell-reports...
Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response
Ras mutations drive tumorigenesis yet persist in normal tissues. Elliot et al. explore
this paradox, finding that HRASG12V induces bifurcating cell fates in the zebrafish
larval epidermis, with lamc2+...
www.cell.com
October 29, 2025 at 5:01 PM
Hot off the press, after years of work by many PG and undergrads and collaborators, we present you wilth a detailed analysis of oncogenic RAS driven cellular plasticity and host immune response within 24 hours of oncogene activation in a #zebrafish model www.cell.com/cell-reports...
Reposted by Yi Feng
The @fengfishlab.bsky.social lab have found that mutation in the Ras gene can change normal cells and trigger an immune response that promotes cancer formation - all within 24 hours. This may offer new ways to detect or prevent cancer before it becomes established.
edin.ac/47h6bZq
edin.ac/47h6bZq
October 29, 2025 at 10:18 AM
The @fengfishlab.bsky.social lab have found that mutation in the Ras gene can change normal cells and trigger an immune response that promotes cancer formation - all within 24 hours. This may offer new ways to detect or prevent cancer before it becomes established.
edin.ac/47h6bZq
edin.ac/47h6bZq
Wondered what my daughter was up to during half-term? She presented these carefully crafted B-day gifts to me this morning! 😊😊
October 29, 2025 at 10:03 AM
Wondered what my daughter was up to during half-term? She presented these carefully crafted B-day gifts to me this morning! 😊😊
Reposted by Yi Feng
Chinese national interested in a PhD using fish?
Fully-funded scholarships @bristolbiosci.bsky.social from the China Scholarship Council-University of Bristol
Success rates are high, check out the details here and get in touch:
www.bristol.ac.uk/students/sup...
Please circulate widely!
Fully-funded scholarships @bristolbiosci.bsky.social from the China Scholarship Council-University of Bristol
Success rates are high, check out the details here and get in touch:
www.bristol.ac.uk/students/sup...
Please circulate widely!
October 29, 2025 at 8:09 AM
Chinese national interested in a PhD using fish?
Fully-funded scholarships @bristolbiosci.bsky.social from the China Scholarship Council-University of Bristol
Success rates are high, check out the details here and get in touch:
www.bristol.ac.uk/students/sup...
Please circulate widely!
Fully-funded scholarships @bristolbiosci.bsky.social from the China Scholarship Council-University of Bristol
Success rates are high, check out the details here and get in touch:
www.bristol.ac.uk/students/sup...
Please circulate widely!
Reposted by Yi Feng
Anyone still using these? We should be able to do an update, if there’s interest. #zebrafish
A parting gift to stay connected ❤️ 🧪
Starter Packs for #zebrafish Community:
ZF Resources: go.bsky.app/JcC5df3
#WomenInScience V1: go.bsky.app/4BegEjv
#WomenInScience V2: go.bsky.app/VoebYrt
ZF PIs V1: go.bsky.app/2cHYybY
ZF PIs V2: go.bsky.app/4zBuxAF
ZF PIs V3: go.bsky.app/JvjuSZg
Starter Packs for #zebrafish Community:
ZF Resources: go.bsky.app/JcC5df3
#WomenInScience V1: go.bsky.app/4BegEjv
#WomenInScience V2: go.bsky.app/VoebYrt
ZF PIs V1: go.bsky.app/2cHYybY
ZF PIs V2: go.bsky.app/4zBuxAF
ZF PIs V3: go.bsky.app/JvjuSZg
October 19, 2025 at 2:08 PM
Anyone still using these? We should be able to do an update, if there’s interest. #zebrafish
Timely and important👇zebrafish cancer models provide unprecedented mechanistic insights on immune-cancer interaction 👏👏👏 solid work takes years to mature!!!
🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social.
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
October 19, 2025 at 10:33 AM
Timely and important👇zebrafish cancer models provide unprecedented mechanistic insights on immune-cancer interaction 👏👏👏 solid work takes years to mature!!!
Reposted by Yi Feng
Zebrafish embryo undergoing gastrulation. Credit to Dr. Gopi Shah at EMBL. #ZebrafishZunday 🧪
October 19, 2025 at 9:24 AM
Zebrafish embryo undergoing gastrulation. Credit to Dr. Gopi Shah at EMBL. #ZebrafishZunday 🧪
Reposted by Yi Feng
Today we are honoured to host Dr Sally Lowell @cellysally.bsky.social (University of Edinburgh), winner of the 2024 BSDB Wolpert Medal, who is giving a talk in our DRN external seminar series
@bsdb.bsky.social
Host: Marysia Placzek
All welcome!
@bsdb.bsky.social
Host: Marysia Placzek
All welcome!
October 15, 2025 at 7:39 AM
Today we are honoured to host Dr Sally Lowell @cellysally.bsky.social (University of Edinburgh), winner of the 2024 BSDB Wolpert Medal, who is giving a talk in our DRN external seminar series
@bsdb.bsky.social
Host: Marysia Placzek
All welcome!
@bsdb.bsky.social
Host: Marysia Placzek
All welcome!
Reposted by Yi Feng
1925: On this date, 100 years ago, The Company of Biologists is founded by George Parker Bidder III. Throughout today, we will be posting some of our key milestones. Read more about the past 100 years at bit.ly/3WnTVA1.
October 15, 2025 at 8:04 AM
1925: On this date, 100 years ago, The Company of Biologists is founded by George Parker Bidder III. Throughout today, we will be posting some of our key milestones. Read more about the past 100 years at bit.ly/3WnTVA1.
Reposted by Yi Feng
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
October 15, 2025 at 6:33 AM
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
Reposted by Yi Feng
Twittering Machine, Paul Klee, 1922, gouache, ink and watercolor on paper
October 9, 2025 at 2:42 PM
Twittering Machine, Paul Klee, 1922, gouache, ink and watercolor on paper
Reposted by Yi Feng
A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 9, 2025 at 3:29 PM
A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]
Reposted by Yi Feng
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Reposted by Yi Feng
Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 8:12 PM
Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Reposted by Yi Feng
Meet the 2025 cohort of @dev-journal.bsky.social Pathway to Independence fellows
Read about the scientific visions of eight dev bio post-docs entering the academic job market
journals.biologists.com/dev/article/...
Read about the scientific visions of eight dev bio post-docs entering the academic job market
journals.biologists.com/dev/article/...
Pathway to Independence: a forecast for the future of developmental biology
ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...
journals.biologists.com
October 1, 2025 at 6:15 AM
Meet the 2025 cohort of @dev-journal.bsky.social Pathway to Independence fellows
Read about the scientific visions of eight dev bio post-docs entering the academic job market
journals.biologists.com/dev/article/...
Read about the scientific visions of eight dev bio post-docs entering the academic job market
journals.biologists.com/dev/article/...
Reposted by Yi Feng
Are you a postdoc interested in the mechanisms of disease?
Do you have a great record and an exciting vision?
Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.
Deadline 30th September...pass it on!
www.path.ox.ac.uk/work-with-us...
Do you have a great record and an exciting vision?
Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.
Deadline 30th September...pass it on!
www.path.ox.ac.uk/work-with-us...
Group Leader Career Development Fellowships - Dunn School
Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?
www.path.ox.ac.uk
September 1, 2025 at 2:39 PM
Are you a postdoc interested in the mechanisms of disease?
Do you have a great record and an exciting vision?
Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.
Deadline 30th September...pass it on!
www.path.ox.ac.uk/work-with-us...
Do you have a great record and an exciting vision?
Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.
Deadline 30th September...pass it on!
www.path.ox.ac.uk/work-with-us...
Reposted by Yi Feng
Transitions in development – an interview with Jeffrey Farrell
@jeffreyafarrell.bsky.social talks about becoming a group leader, his insights on advocacy for developmental biology and his belief in unifying single-cell biology with classical approaches.
journals.biologists.com/dev/article/...
@jeffreyafarrell.bsky.social talks about becoming a group leader, his insights on advocacy for developmental biology and his belief in unifying single-cell biology with classical approaches.
journals.biologists.com/dev/article/...
July 28, 2025 at 4:06 PM
Transitions in development – an interview with Jeffrey Farrell
@jeffreyafarrell.bsky.social talks about becoming a group leader, his insights on advocacy for developmental biology and his belief in unifying single-cell biology with classical approaches.
journals.biologists.com/dev/article/...
@jeffreyafarrell.bsky.social talks about becoming a group leader, his insights on advocacy for developmental biology and his belief in unifying single-cell biology with classical approaches.
journals.biologists.com/dev/article/...
Reposted by Yi Feng
Hey friends - Daniocell is experiencing a temporary outage right now. The NICHD server it is hosted on got dropped from the NIH’s firewall list & so currently can’t be accessed outside the NIH. The relevant IT teams are working to resolve it. Sorry for any inconvenience. It’ll be back soon!!
July 29, 2025 at 9:58 PM
Hey friends - Daniocell is experiencing a temporary outage right now. The NICHD server it is hosted on got dropped from the NIH’s firewall list & so currently can’t be accessed outside the NIH. The relevant IT teams are working to resolve it. Sorry for any inconvenience. It’ll be back soon!!
Reposted by Yi Feng
#IZFC2025 #zebrafish #DANIO-CODE data coordination centre is back online. Note changed address: danio-code-dcc.genereg.net
DANIO-CODE DCC
This Data Coordination Center allows DANIO-CODE consortium members to submit and view their data sets annotated with standard metadata nomenclatures.
danio-code-dcc.genereg.net
July 13, 2025 at 12:23 PM
#IZFC2025 #zebrafish #DANIO-CODE data coordination centre is back online. Note changed address: danio-code-dcc.genereg.net
Reposted by Yi Feng
Wrote a big review with my friend and colleague @varshneylab.social on the state-of-the-art in CRISPR used experimentally in vivo. We wanted to focus on their use in experimental vertebrate animals (apparently passé now but we persist).
CRISPR-based functional genomics tools in vertebrate models - Experimental & Molecular Medicine
Recent advances in DNA sequencing have allowed scientists to gather vast amounts of genetic data, but understanding what those sequences actually do requires additional tools that allow scientists to ...
www.nature.com
July 31, 2025 at 4:08 PM
Wrote a big review with my friend and colleague @varshneylab.social on the state-of-the-art in CRISPR used experimentally in vivo. We wanted to focus on their use in experimental vertebrate animals (apparently passé now but we persist).
Reposted by Yi Feng
Speaker update for our Generative Biology workshop: we are delighted to have @nmoris.bsky.social join us. See full list of speakers on the attached flyer or on our website.
Apply by 15th August. Places available for short talks.
royalsociety.org/science-even...
Apply by 15th August. Places available for short talks.
royalsociety.org/science-even...
July 28, 2025 at 9:42 AM
Speaker update for our Generative Biology workshop: we are delighted to have @nmoris.bsky.social join us. See full list of speakers on the attached flyer or on our website.
Apply by 15th August. Places available for short talks.
royalsociety.org/science-even...
Apply by 15th August. Places available for short talks.
royalsociety.org/science-even...