Chris Peritore-Galve
@fcperitore.bsky.social
Postdoc in the Borden Lacy Lab at Vanderbilt University Medical Center | Incoming Assistant Professor at The Ohio State University | Professional 🦠and 💩 aficionado | Non-professional 🪴🐶🐦 enthusiast| 🇲🇽 🇺🇸 |
🧪Thrilled to share our new study "The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice” in PLoS Pathogens! @bordenlacy.bsky.social
➡️We show that this mAb alone protects against infection with strains encoding TcdB variants. 1/20
➡️We show that this mAb alone protects against infection with strains encoding TcdB variants. 1/20
journals.plos.org
November 7, 2025 at 7:11 PM
🧪Thrilled to share our new study "The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice” in PLoS Pathogens! @bordenlacy.bsky.social
➡️We show that this mAb alone protects against infection with strains encoding TcdB variants. 1/20
➡️We show that this mAb alone protects against infection with strains encoding TcdB variants. 1/20
Excited to share our recent review in which @rcglover.bsky.social, @joeyzacks.bsky.social, @bordenlacy.bsky.social, and I discuss current advances in our understanding of immunity to C. difficile infection and what it will take to develop an effective vaccine 💉
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Immune Aspects of Clostridioides difficile Infection and Vaccine Development
www.sciencedirect.com
August 28, 2025 at 9:27 PM
Excited to share our recent review in which @rcglover.bsky.social, @joeyzacks.bsky.social, @bordenlacy.bsky.social, and I discuss current advances in our understanding of immunity to C. difficile infection and what it will take to develop an effective vaccine 💉
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Chris Peritore-Galve
1/ Excited to share the first preprint from my lab! 🎉
My postdoc Paz asked how cholera toxin (CT) helps Vibrio cholerae thrive in the gut.
Turns out, CT rewires epithelial metabolism toward L-lactate production—fueling pathogen growth in the small intestine during disease
My postdoc Paz asked how cholera toxin (CT) helps Vibrio cholerae thrive in the gut.
Turns out, CT rewires epithelial metabolism toward L-lactate production—fueling pathogen growth in the small intestine during disease
Cholera toxin-induced disease generates epithelial cell-derived L-lactate that promotes Vibrio cholerae growth in the small intestine
Cholera toxin (CT) promotes Vibrio cholerae colonization by altering gut metabolism to favor pathogen growth. We have previously found that CT-induced disease leads to increased concentrations of L-la...
www.biorxiv.org
August 18, 2025 at 9:13 PM
1/ Excited to share the first preprint from my lab! 🎉
My postdoc Paz asked how cholera toxin (CT) helps Vibrio cholerae thrive in the gut.
Turns out, CT rewires epithelial metabolism toward L-lactate production—fueling pathogen growth in the small intestine during disease
My postdoc Paz asked how cholera toxin (CT) helps Vibrio cholerae thrive in the gut.
Turns out, CT rewires epithelial metabolism toward L-lactate production—fueling pathogen growth in the small intestine during disease
Reposted by Chris Peritore-Galve
Imagine this: On the evening of March 8, you and your spouse unlock the door to your apartment building. As you step inside, two men—not in uniform—push their way in behind you. They tell you your visa has been revoked and that they are there to deport you.
March 12, 2025 at 6:46 PM
Imagine this: On the evening of March 8, you and your spouse unlock the door to your apartment building. As you step inside, two men—not in uniform—push their way in behind you. They tell you your visa has been revoked and that they are there to deport you.
Reposted by Chris Peritore-Galve
In 2024 NIH grant awards supported 407,782 jobs and $94.58 billion in new economic activity nationwide, the largest figure in the history of the report. www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 13, 2025 at 12:55 AM
In 2024 NIH grant awards supported 407,782 jobs and $94.58 billion in new economic activity nationwide, the largest figure in the history of the report. www.forbes.com/sites/michae...
Reposted by Chris Peritore-Galve
Preliminary injunction in nationwide indirect cost rate case.
This means that the judge found that the plaintiffs (AAMC, et al.) are likely to win on the merits when the ruling is finalized.
www.statnews.com/2025/03/05/n...
This means that the judge found that the plaintiffs (AAMC, et al.) are likely to win on the merits when the ruling is finalized.
www.statnews.com/2025/03/05/n...
Judge issues preliminary injunction blocking Trump cuts to NIH research overhead payments
A federal judge issued a nationwide preliminary injunction blocking the Trump administration from slashing NIH payments for research overhead
www.statnews.com
March 5, 2025 at 9:08 PM
Preliminary injunction in nationwide indirect cost rate case.
This means that the judge found that the plaintiffs (AAMC, et al.) are likely to win on the merits when the ruling is finalized.
www.statnews.com/2025/03/05/n...
This means that the judge found that the plaintiffs (AAMC, et al.) are likely to win on the merits when the ruling is finalized.
www.statnews.com/2025/03/05/n...
Reposted by Chris Peritore-Galve
A federal judge in Massachusetts today blocked an attempt by the National Institutes of Health to cut some $4 billion annually that goes to universities to cover the cost of supporting research on their campuses.
U.S. judge blocks NIH’s plan to slash overhead cost payments
Injunction allows universities to keep receiving billions to recover costs of supporting federal research on campus
scim.ag
March 5, 2025 at 10:40 PM
A federal judge in Massachusetts today blocked an attempt by the National Institutes of Health to cut some $4 billion annually that goes to universities to cover the cost of supporting research on their campuses.
Reposted by Chris Peritore-Galve
This is Marco Rubio explaining how the USA promised to defend Ukraine forever if they got rid of their nuclear arsenal left after the Soviet Union fell.
This is why lil marco was sinking into the couch. He was hoping we wouldn’t find it…so don’t RT right now this very second.
This is why lil marco was sinking into the couch. He was hoping we wouldn’t find it…so don’t RT right now this very second.
March 2, 2025 at 4:55 PM
This is Marco Rubio explaining how the USA promised to defend Ukraine forever if they got rid of their nuclear arsenal left after the Soviet Union fell.
This is why lil marco was sinking into the couch. He was hoping we wouldn’t find it…so don’t RT right now this very second.
This is why lil marco was sinking into the couch. He was hoping we wouldn’t find it…so don’t RT right now this very second.
Reposted by Chris Peritore-Galve
Everyone who ever got funding through NIAID should be aware of this bill and start sending messages to their US legislators. The bill intends to dissolve NIAID. This is Project 2025
www.congress.gov/bill/119th-c...
www.congress.gov/bill/119th-c...
www.congress.gov
February 22, 2025 at 9:38 PM
Everyone who ever got funding through NIAID should be aware of this bill and start sending messages to their US legislators. The bill intends to dissolve NIAID. This is Project 2025
www.congress.gov/bill/119th-c...
www.congress.gov/bill/119th-c...
Reposted by Chris Peritore-Galve
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Graduate Reductions Across Biomedical Sciences (2025)
docs.google.com
February 22, 2025 at 1:23 PM
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Reposted by Chris Peritore-Galve
Several good things are happening according r/fednews so I am going to drop them here. If federal workers are fighting back, how much more us?
A thread/
A thread/
February 22, 2025 at 12:47 PM
Several good things are happening according r/fednews so I am going to drop them here. If federal workers are fighting back, how much more us?
A thread/
A thread/
Reposted by Chris Peritore-Galve
🚨 WANT TO HELP US STAND UP FOR SCIENCE? 🚨
Here's a little update on where we're currently at with the planning process!
Is your state red or grey & you want to see an event happen? Fill out our volunteer form or share with a friend! airtable.com/app4h5wUssMG...
#standupforscience2025
Here's a little update on where we're currently at with the planning process!
Is your state red or grey & you want to see an event happen? Fill out our volunteer form or share with a friend! airtable.com/app4h5wUssMG...
#standupforscience2025
February 22, 2025 at 5:19 AM
🚨 WANT TO HELP US STAND UP FOR SCIENCE? 🚨
Here's a little update on where we're currently at with the planning process!
Is your state red or grey & you want to see an event happen? Fill out our volunteer form or share with a friend! airtable.com/app4h5wUssMG...
#standupforscience2025
Here's a little update on where we're currently at with the planning process!
Is your state red or grey & you want to see an event happen? Fill out our volunteer form or share with a friend! airtable.com/app4h5wUssMG...
#standupforscience2025
Reposted by Chris Peritore-Galve
🚨PA colleagues:
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
Microsoft Forms
forms.office.com
February 22, 2025 at 8:12 PM
🚨PA colleagues:
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
Reposted by Chris Peritore-Galve
PLOS has issued a statement on recent US Executive Orders and scientific integrity.
We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.
plos.io/3D4O8cH
We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.
plos.io/3D4O8cH
PLOS statement on recent US Executive Orders and scientific integrity - The Official PLOS Blog
Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…
plos.io
February 21, 2025 at 3:41 PM
PLOS has issued a statement on recent US Executive Orders and scientific integrity.
We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.
plos.io/3D4O8cH
We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.
plos.io/3D4O8cH
Reposted by Chris Peritore-Galve
Ok scientists & those who love science 🧪: here is another exhortation. Call Congress TODAY about the freeze on NIH Council Meetings and Study Sections. Emphasize that this means NO new grants are being funded & labs will soon start to shut down and fire employees. Phone numbers are at:
5calls.org
5calls.org
5 Calls
Spend 5 minutes. Make 5 calls. Make your voice heard.
5calls.org
February 21, 2025 at 5:23 PM
Ok scientists & those who love science 🧪: here is another exhortation. Call Congress TODAY about the freeze on NIH Council Meetings and Study Sections. Emphasize that this means NO new grants are being funded & labs will soon start to shut down and fire employees. Phone numbers are at:
5calls.org
5calls.org
Reposted by Chris Peritore-Galve
Once again, these include a host of individual and institutional training grants that broaden participation in biomedical research: IMSD, MARC, U-RISE, G-RISE, Bridges to Doctorates, MOSAIC, etc.
This strategy is nefarious and in direct conflict with the recent injunction against Trump anti-DEI EOs
This strategy is nefarious and in direct conflict with the recent injunction against Trump anti-DEI EOs
More Friday night villainy: many NIH grant opportunities that disappeared two weeks ago and then reappeared last week have now disappeared again 🤬
Search grants.gov with close date in ascending order - 2 pages with closing dates now today (2/21/25), many with archive date tomorrow (2/22/25)
Search grants.gov with close date in ascending order - 2 pages with closing dates now today (2/21/25), many with archive date tomorrow (2/22/25)
Home | Grants.govLock
grants.gov
February 22, 2025 at 2:01 AM
Once again, these include a host of individual and institutional training grants that broaden participation in biomedical research: IMSD, MARC, U-RISE, G-RISE, Bridges to Doctorates, MOSAIC, etc.
This strategy is nefarious and in direct conflict with the recent injunction against Trump anti-DEI EOs
This strategy is nefarious and in direct conflict with the recent injunction against Trump anti-DEI EOs
Reposted by Chris Peritore-Galve
It’s been buried in all the news today, but every scientist in the US should pay attention to this:
Mike Lauer went out on a limb for us all, sending out a memo saying institutes should start awarding grants. And it looks like Trump/Musk fired him for that. 🧪
Mike Lauer went out on a limb for us all, sending out a memo saying institutes should start awarding grants. And it looks like Trump/Musk fired him for that. 🧪
NEW: In a further sign of turmoil at the NIH, Mike Lauer, who oversees the agency's $39 billion extramural budget that goes to research outside the NIH, has resigned effective tomorrow.
This comes after top NIH official Larry Tabak abruptly retired yesterday.
This comes after top NIH official Larry Tabak abruptly retired yesterday.
February 14, 2025 at 9:40 PM
It’s been buried in all the news today, but every scientist in the US should pay attention to this:
Mike Lauer went out on a limb for us all, sending out a memo saying institutes should start awarding grants. And it looks like Trump/Musk fired him for that. 🧪
Mike Lauer went out on a limb for us all, sending out a memo saying institutes should start awarding grants. And it looks like Trump/Musk fired him for that. 🧪
Reposted by Chris Peritore-Galve
CDC source:
“We just had word that all our fellows and post doc staff are laid off effective immediately. The famous Epidemic Intelligence Service, aka the Disease Detectives, is no more. That’s 1260 staff.
They are calling this ‘Phase 1’.”
“We just had word that all our fellows and post doc staff are laid off effective immediately. The famous Epidemic Intelligence Service, aka the Disease Detectives, is no more. That’s 1260 staff.
They are calling this ‘Phase 1’.”
February 14, 2025 at 7:58 PM
CDC source:
“We just had word that all our fellows and post doc staff are laid off effective immediately. The famous Epidemic Intelligence Service, aka the Disease Detectives, is no more. That’s 1260 staff.
They are calling this ‘Phase 1’.”
“We just had word that all our fellows and post doc staff are laid off effective immediately. The famous Epidemic Intelligence Service, aka the Disease Detectives, is no more. That’s 1260 staff.
They are calling this ‘Phase 1’.”
Reposted by Chris Peritore-Galve
This new Administration is a bunch of terrorists blowing up all that is meant to keep us safe and healthy.
CDC cuts expected to devastate Epidemic Intelligence Service, a ‘crown jewel’ of public health www.statnews.com/2025/02/14/t... via @statnews.com
CDC cuts expected to devastate Epidemic Intelligence Service, a ‘crown jewel’ of public health www.statnews.com/2025/02/14/t... via @statnews.com
CDC cuts expected to devastate Epidemic Intelligence Service, a ‘crown jewel’ of public health
Members of the CDC's Epidemic Intelligence Service were warned Friday that many of them were about to be fired
www.statnews.com
February 14, 2025 at 9:33 PM
This new Administration is a bunch of terrorists blowing up all that is meant to keep us safe and healthy.
CDC cuts expected to devastate Epidemic Intelligence Service, a ‘crown jewel’ of public health www.statnews.com/2025/02/14/t... via @statnews.com
CDC cuts expected to devastate Epidemic Intelligence Service, a ‘crown jewel’ of public health www.statnews.com/2025/02/14/t... via @statnews.com
Reposted by Chris Peritore-Galve
Hi Vanderbilt, with your $545 million in NIH funding — how’s it going over there?
Where NIH funding went last year.
s2.washingtonpost.com/camp-rw/?tra...
s2.washingtonpost.com/camp-rw/?tra...
February 11, 2025 at 6:51 PM
Hi Vanderbilt, with your $545 million in NIH funding — how’s it going over there?
Reposted by Chris Peritore-Galve
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
Reposted by Chris Peritore-Galve
Executive wants to frame the NIH indirects cut as $4B in savings.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
www.nih.gov
February 8, 2025 at 3:08 AM
Executive wants to frame the NIH indirects cut as $4B in savings.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
Reposted by Chris Peritore-Galve
@asm.org this better not be anticipatory obedience. I have 5 lab members planning on going to ASM microbe this year. I will absolutely pivot to another meeting if ASM gives in to anti-DEI efforts.
@vscooper.micropopbio.org and @mostlymicrobes.bsky.social while downloading scientist spotlights for teaching from the site; ASM has also scrubbed the entire IDEAA page including resources on LGBTQ+ scientists at asm.org/IDEAA/resources/pride-month
February 2, 2025 at 6:30 PM
@asm.org this better not be anticipatory obedience. I have 5 lab members planning on going to ASM microbe this year. I will absolutely pivot to another meeting if ASM gives in to anti-DEI efforts.
Reposted by Chris Peritore-Galve
Read the news and views on this paper by Amandine Everard & co here:
A gut microorganism turns the dial on sugar intake
www.nature.com/articles/s41...
A gut microorganism turns the dial on sugar intake
www.nature.com/articles/s41...
January 30, 2025 at 9:06 AM
Read the news and views on this paper by Amandine Everard & co here:
A gut microorganism turns the dial on sugar intake
www.nature.com/articles/s41...
A gut microorganism turns the dial on sugar intake
www.nature.com/articles/s41...