Fay Roberts
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fayroberts.bsky.social
Fay Roberts
@fayroberts.bsky.social
1.6K followers 1.1K following 830 posts
Queer, disabled, Welsh(ish), progressive performance poet/ musician/ project manager/ event host/ musician/ award-winning voice actor. Lover of spreadsheets and creative writing. ze/zir or they/them/their https://linktr.ee/fayroberts
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Reposted by Fay Roberts
lawofnames.com
This episode was written, edited, & sound designed by @edilmh.bsky.social

It features
@cadeyelise.bsky.social as Celia
@achill3a.bsky.social as Lucy

with
@fayroberts.bsky.social as The Ringmaster
November 8, 2025 at 7:11 PM
Reposted by Fay Roberts
sailorrooscout.bsky.social
Researchers envision their vaccine being used as both a treatment and a preventive, and as an approach to treating multiple cancer types.
• www.umass.edu/news/article...

The study has been published in Cell Reports Medicine. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️
HIGHLIGHTS • Lipid NPs carrying STING and TLR4 agonists promote synergistic type I interferons • NPs drain efficiently to lymph nodes and increase polyfunctional T and B cells • NPs improve tumor-free outcomes with memory against multiple aggressive tumor models SUMMARY We report on the utility of a "super-adjuvant" nanoparticle (NP) system as a modular, customizable platform for next-generation cancer vaccination. Using nanomaterials engineering technology, we aim to harness not only the effective adjuvanticity of whole-pathogen vaccines, but also the safety of subunit vaccines. Our lipid-based NP platform co-encapsulates agonists of the stimulator of interferon genes (STING) and Toll-like receptor 4 (TLR4) pathways to promote synergistic production of type I interferons and other proinflammatory cytokines in innate antigen-presenting dendritic cells and macrophages. Compared to empty NPs and free agonists, dual-adjuvant NPs administered with antigenic peptides or tumor cell lysate promote increased antigen processing and presentation, drain efficiently to nearby lymph nodes, increase polyfunctional tumor-specific T and B cells, and improve tumor-free outcomes upon vaccination and subsequent challenge with multiple aggressive tumor cells. Graphical Abstract The vaccine combines two immune-stimulating molecules (adjuvants) in a tiny lipid nanoparticle that enhances both innate and adaptive immune responses. The innate immune system acts as the body’s first line of defense, responding quickly and non-specifically to invaders using cells that release inflammatory signals. The adaptive immune system takes longer to activate but provides a targeted, long-lasting response, training T-cells and B- cells to recognize and remember specific threats. Together, they form a coordinated defense: the innate system alerts and activates the adaptive system, which then delivers precise and durable immunity.
November 5, 2025 at 5:02 PM
fayroberts.bsky.social
Not me, but tagging @timclare.bsky.social because this is the perfect Venn Diagram intersection.
November 5, 2025 at 3:34 AM
Reposted by Fay Roberts
lawofnames.com
@sophiachung.info as Mom
@justinnelsonva.bsky.social as the Puppeteer
Jack Fulmin as Laya
@kirstywoolven.bsky.social as Lorrel

With
@fayroberts.bsky.social as The Ringmaster
November 3, 2025 at 4:18 PM
Reposted by Fay Roberts
secretaboutbox.bsky.social
i absolutely do not want bluesky to automoderate my threads. this is *absurd.*
October 31, 2025 at 9:27 PM
fayroberts.bsky.social
Fun fact: putting smart lights in my house means I can make the whole place flicker.

Also: props to the young dad who said, smiling, to his transfixed toddler: "Go on, thank them." then "She's just a bit confused…" to me.
October 31, 2025 at 7:00 PM