Convincing myself that aging is simply loss of regulation/repair and could be quantified and reversed!
I wrote a book! BIOLOGICAL YOUTH http://amazon.com/dp/1535584459
www.nature.com/articles/d41...
Even more problematic:
Each geroscientist is convinced that they themselves know what aging is
What do you think aging is?
— Loss of function?
— Accumulated damage?
— A disease?
— A continuation of development?
#colibactin
— produced by #pathogenic Escherichia coli #bacteria
— associated with DNA damage & CRC
— α-ketoiminium group binds DNA minor grove
— explains DNA signature observed in human CRC cells
#health #science 🧪
#colibactin
— produced by #pathogenic Escherichia coli #bacteria
— associated with DNA damage & CRC
— α-ketoiminium group binds DNA minor grove
— explains DNA signature observed in human CRC cells
#health #science 🧪
www.euronews.com/health/2025/...
— ink rapidly accumulates in lymph nodes
— ink #nanoparticles recognized as foreign
— black ink carbon
— colored ink used in industrial plastics, varnishes, paints
#health #science 🧪 #lab #animal 🐁
www.euronews.com/health/2025/...
— ink rapidly accumulates in lymph nodes
— ink #nanoparticles recognized as foreign
— black ink carbon
— colored ink used in industrial plastics, varnishes, paints
#health #science 🧪 #lab #animal 🐁
med.stanford.edu/news/all-new...
— 19 in 20 ppl have latent EBV infection
— in healthy ppl, 1 in 10,000 B cells carry EBV RNA
— in lupus pts, 1 in 400 B cells carry EBV RNA, 25x incr.
#science 🧪
med.stanford.edu/news/all-new...
— 19 in 20 ppl have latent EBV infection
— in healthy ppl, 1 in 10,000 B cells carry EBV RNA
— in lupus pts, 1 in 400 B cells carry EBV RNA, 25x incr.
#science 🧪
www.frontiersin.org/journals/nut...
Cross-sectional survey associations (N = 443)
Fruit smoothies
— best overall #health
— mental health
— energy levels
Fruit juices
— poorest health
— high cholesterol
— low sleep quality
#science 🧪
www.frontiersin.org/journals/nut...
Cross-sectional survey associations (N = 443)
Fruit smoothies
— best overall #health
— mental health
— energy levels
Fruit juices
— poorest health
— high cholesterol
— low sleep quality
#science 🧪
www.npr.org/2025/11/24/n...
> Home cooked vs processed
> Avoid white breads
> Beans legumes for fiber
#health #science 🧪
www.npr.org/2025/11/24/n...
> Home cooked vs processed
> Avoid white breads
> Beans legumes for fiber
#health #science 🧪
www.nature.com/articles/s41...
— ratio of 3 glycine: 1 proline: 1 hydroxyproline
— motility-healthspan of C. elegans
— grip strength in mice
— skin features & biological age after 6 mo in humans
#science 🧪
www.nature.com/articles/s41...
— ratio of 3 glycine: 1 proline: 1 hydroxyproline
— motility-healthspan of C. elegans
— grip strength in mice
— skin features & biological age after 6 mo in humans
#science 🧪
medicalxpress.com/news/2025-11...
— 121 ppl with GRIN2A variant analyzed
— GRIN2A variants reduce activity of NMDA receptor
— 4 patients benefit with dietary supplement L-serine
#health #science 🧪
medicalxpress.com/news/2025-11...
— 121 ppl with GRIN2A variant analyzed
— GRIN2A variants reduce activity of NMDA receptor
— 4 patients benefit with dietary supplement L-serine
#health #science 🧪
bmcmededuc.biomedcentral.com/articles/10....
— Physicians lack knowledge, skills, confidence, training to effectively counsel nutrition
— Nutrition training during residency fixes
— More evidence-based training guidelines needed
bmcmededuc.biomedcentral.com/articles/10....
— Physicians lack knowledge, skills, confidence, training to effectively counsel nutrition
— Nutrition training during residency fixes
— More evidence-based training guidelines needed
📢 New meta-analysis shows lifestyle changes + GLP-1RAs lead to major weight loss & biomarker gains!
🔗 www.linkedin.com/feed/update/...
🌐 #GLP1 #DHPSP @hipecsurvivor.bsky.social @martinbue.bsky.social @shawneexo.bsky.social @holyunknown.bsky.social @alisyngayle.bsky.social @ustinoff.bsky.social
📢 New meta-analysis shows lifestyle changes + GLP-1RAs lead to major weight loss & biomarker gains!
🔗 www.linkedin.com/feed/update/...
🌐 #GLP1 #DHPSP @hipecsurvivor.bsky.social @martinbue.bsky.social @shawneexo.bsky.social @holyunknown.bsky.social @alisyngayle.bsky.social @ustinoff.bsky.social
🩺 Cardiometabolic boost: lower blood pressure, HbA1c, cholesterol with GLP-1RA + lifestyle combo.
🌐 #CardioHealth #Diabetes #GLP1RA @manjeet786.bsky.social @alfredodistefano.bsky.social @nicksevillaz.bsky.social @spatzlhirn.bsky.social @ewingt-phd.bsky.social
🩺 Cardiometabolic boost: lower blood pressure, HbA1c, cholesterol with GLP-1RA + lifestyle combo.
🌐 #CardioHealth #Diabetes #GLP1RA @manjeet786.bsky.social @alfredodistefano.bsky.social @nicksevillaz.bsky.social @spatzlhirn.bsky.social @ewingt-phd.bsky.social
www.acc.org/Latest-in-Ca...
— feeds good gut bacteria
— lowers inflammation, cholesterol, blood sugar
— lowers cholesterol, BP, body weight
— 25-38 g fiber/d from fruits, vegetables, legumes, whole grains
#cardiovascular #diet #longevity
www.acc.org/Latest-in-Ca...
— feeds good gut bacteria
— lowers inflammation, cholesterol, blood sugar
— lowers cholesterol, BP, body weight
— 25-38 g fiber/d from fruits, vegetables, legumes, whole grains
#cardiovascular #diet #longevity
www.lifespan.io/news/mainten...
— greater autophagy in older adults may be result of larger amount of damaged material
— autolysosomes more heterogenous & may be less resilient to stress
via @lifespanio.bsky.social
#science 🧪
www.lifespan.io/news/mainten...
— greater autophagy in older adults may be result of larger amount of damaged material
— autolysosomes more heterogenous & may be less resilient to stress
via @lifespanio.bsky.social
#science 🧪
research.arizona.edu/news/u-scien...
— glucagon critical for healthspan stimulated by calorie restriction
— glucagon agonism in aging mice suppresses pathways that accelerate aging
#health #science #research 🧪
research.arizona.edu/news/u-scien...
— glucagon critical for healthspan stimulated by calorie restriction
— glucagon agonism in aging mice suppresses pathways that accelerate aging
#health #science #research 🧪
link.springer.com/article/10.1...
— incr NAD⁺ levels, AMPK, SIRT1
— decr mTOR
Improving:
— autophagy
— oxidative stress
— mitochondrial function
— β-cell mass & function
🧪 #health #science #research
time.com/7330284/agin...
— Optimize sleep, exercise, diet, social connectivity
— Intermittent fast 16 hours every day
— lost some weight
— gained muscle
— lost the fogginess during the day
time.com/7330284/agin...
— Optimize sleep, exercise, diet, social connectivity
— Intermittent fast 16 hours every day
— lost some weight
— gained muscle
— lost the fogginess during the day
theconversation.com/your-gluten-...
#glutenfree risks:
> 139% more expensive
> lower in fiber & key nutrients
> reduces diversity in diet
> alters gut microbes
> reinforces anxiety about eating
🧪 #health #science #diet
theconversation.com/your-gluten-...
#glutenfree risks:
> 139% more expensive
> lower in fiber & key nutrients
> reduces diversity in diet
> alters gut microbes
> reinforces anxiety about eating
🧪 #health #science #diet
theconversation.com/your-gluten-...
#glutenfree risks:
> 139% more expensive
> lower in fiber & key nutrients
> reduces diversity in diet
> alters gut microbes
> reinforces anxiety about eating
🧪 #health #science #diet
🔬 Science-backed, not hype. These 6 compound types are changing the game in nutrition & health
👉 www.linkedin.com/feed/update/...
🌐 #INPST #FunctionalFoods #HealthScience @hipecsurvivor.bsky.social @martinbue.bsky.social @alisyngayle.bsky.social @holyunknown.bsky.social @shawneexo.bsky.social
🔬 Science-backed, not hype. These 6 compound types are changing the game in nutrition & health
👉 www.linkedin.com/feed/update/...
🌐 #INPST #FunctionalFoods #HealthScience @hipecsurvivor.bsky.social @martinbue.bsky.social @alisyngayle.bsky.social @holyunknown.bsky.social @shawneexo.bsky.social
www.nature.com/articles/d41...
— Cancer patients treated with checkpoint inhibitors show stronger anti-tumor immunity if had COVID19 mRNA vaccine
— Vaccine activates immune system throughout entire body including inside the tumor
#science 🧪
www.nature.com/articles/d41...
— Cancer patients treated with checkpoint inhibitors show stronger anti-tumor immunity if had COVID19 mRNA vaccine
— Vaccine activates immune system throughout entire body including inside the tumor
#science 🧪
www.sciencedirect.com/science/arti...
— randomized controlled trial
— 25 receive 300 mg/d ALA vs 25 placebo
— at 3 months, lower serum HbA1c & oxidation biomarkers
#science 🧪
www.sciencedirect.com/science/arti...
— randomized controlled trial
— 25 receive 300 mg/d ALA vs 25 placebo
— at 3 months, lower serum HbA1c & oxidation biomarkers
#science 🧪
— exposure to fine particulate matter (PM₂․₅), nitrogen oxides, traffic-related pollutants
— 28% of dementia deaths
— 7.9 million deaths from all causes
— 610,000 deaths babies under 1 yo
healthpolicy-watch.news/air-pollutio...
— exposure to fine particulate matter (PM₂․₅), nitrogen oxides, traffic-related pollutants
— 28% of dementia deaths
— 7.9 million deaths from all causes
— 610,000 deaths babies under 1 yo
healthpolicy-watch.news/air-pollutio...
www.nature.com/articles/d41...
Involution of breast after weaning induces:
— older, damaged cells cleared out
— new cells created
— specialized T cells take residency for up to 50 years!
#science 🧪
www.nature.com/articles/d41...
Involution of breast after weaning induces:
— older, damaged cells cleared out
— new cells created
— specialized T cells take residency for up to 50 years!
#science 🧪
jhpn.biomedcentral.com/articles/10....
Time-restricted feeding:
— Consume bulk of calories earlier in the day
— Avoid late-night eating
Associated with improvements in:
— insulin sensitivity
— weight regulation
— cardiometabolic health
#health
jhpn.biomedcentral.com/articles/10....
Time-restricted feeding:
— Consume bulk of calories earlier in the day
— Avoid late-night eating
Associated with improvements in:
— insulin sensitivity
— weight regulation
— cardiometabolic health
#health
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CalRx® Insulin costs $11/pen
CalRx® Insulin costs $11/pen
CalRx® Insulin costs $11/pen
CalRx® Insulin costs $11/pen
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www.nature.com/articles/s41...
In #mouse model of multiple organ dysfunction syndrome #MODS model, NRF2 activation caused:
— decr. inflammatory cytokines
— incr. blood flow, kidney & liver function
— incr. survival
#science 🧪
www.nature.com/articles/s41...
In #mouse model of multiple organ dysfunction syndrome #MODS model, NRF2 activation caused:
— decr. inflammatory cytokines
— incr. blood flow, kidney & liver function
— incr. survival
#science 🧪