Dr. Todd Ewing PhD.
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ewingt-phd.bsky.social
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social
Drug Discovery / Aging / Fitness
Convincing myself that aging is simply loss of regulation/repair and could be quantified and reversed!
I wrote a book! BIOLOGICAL YOUTH http://amazon.com/dp/1535584459
Pinned
#Geroscience can't agree what #aging is

www.nature.com/articles/d41...

Even more problematic:

Each geroscientist is convinced that they themselves know what aging is

What do you think aging is?
— Loss of function?
— Accumulated damage?
— A disease?
— A continuation of development?
What is ageing? Even the field’s researchers can’t agree
Survey of scientists who study ageing finds no consensus on the fundamentals.
www.nature.com
US Researchers determine how #gut #dysbiosis leads to #colorectal #cancer CRC

#colibactin

— produced by #pathogenic Escherichia coli #bacteria
— associated with DNA damage & CRC
— α-ketoiminium group binds DNA minor grove
— explains DNA signature observed in human CRC cells

#health #science 🧪
December 5, 2025 at 8:17 PM
Swiss researchers study #tattoo #ink & #inflammation in #mouse

www.euronews.com/health/2025/...

— ink rapidly accumulates in lymph nodes
— ink #nanoparticles recognized as foreign
— black ink carbon
— colored ink used in industrial plastics, varnishes, paints

#health #science 🧪 #lab #animal 🐁
Could tattoos threaten your defences? Scientists aim to find out
Tattoos may do more than decorate the skin — they could also alter how the body responds to disease, according to new research.
www.euronews.com
December 5, 2025 at 8:08 PM
Researchers @stanforduniversity.bsky.social uncover role of Epstein-Barr Virus & B cells in #lupus

med.stanford.edu/news/all-new...

— 19 in 20 ppl have latent EBV infection
— in healthy ppl, 1 in 10,000 B cells carry EBV RNA
— in lupus pts, 1 in 400 B cells carry EBV RNA, 25x incr.

#science 🧪
Stanford Medicine scientists tie lupus to a virus nearly all of us carry
The Epstein-Barr virus can convert B cells it’s infected into diabolical overlords that reprogram myriad other immune cells to attack our tissues, Stanford Medicine scientists have found.
med.stanford.edu
November 26, 2025 at 8:42 PM
UCLA researcher discovers the healthiest way to eat #fruit

www.frontiersin.org/journals/nut...

Cross-sectional survey associations (N = 443)

Fruit smoothies
— best overall #health
— mental health
— energy levels

Fruit juices
— poorest health
— high cholesterol
— low sleep quality

#science 🧪
Frontiers | Health Associations of Various Fruit Forms: Solid Fruits, Juices, and Smoothies
The rising prevalence of noncommunicable diseases (NCDs) highlights the need for refined dietary recommendations that distinguish between forms of fruit cons...
www.frontiersin.org
November 26, 2025 at 5:48 AM
Nutritional psychiatry finds foods for good mood

www.npr.org/2025/11/24/n...

> Home cooked vs processed
> Avoid white breads
> Beans legumes for fiber

#health #science 🧪
What foods make you happiest? It's not what you think
As you prepare for your holiday feast, here's something to consider. Research suggests there are certain foods that can help boost our moods and make us happier in the long-run.
www.npr.org
November 25, 2025 at 5:00 AM
Swiss researchers identify amino acid #supplementation to promote collagen & #longevity!

www.nature.com/articles/s41...

— ratio of 3 glycine: 1 proline: 1 hydroxyproline
— motility-healthspan of C. elegans
— grip strength in mice
— skin features & biological age after 6 mo in humans

#science 🧪
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo - npj Aging
npj Aging - A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo
www.nature.com
November 21, 2025 at 11:47 PM
Variants of single gene GRIN2A linked to early onset of mental illness particularly schizophrenia

medicalxpress.com/news/2025-11...

— 121 ppl with GRIN2A variant analyzed
— GRIN2A variants reduce activity of NMDA receptor
— 4 patients benefit with dietary supplement L-serine

#health #science 🧪
Changes in a single gene can cause mental illness, study reveals
Until now, researchers assumed that schizophrenia, anxiety disorders or depression arise from an interplay of many different factors, including genetic ones.
medicalxpress.com
November 15, 2025 at 7:39 PM
Canadian researchers show #medical training must include #nutrition

bmcmededuc.biomedcentral.com/articles/10....

— Physicians lack knowledge, skills, confidence, training to effectively counsel nutrition
— Nutrition training during residency fixes
— More evidence-based training guidelines needed
Do doctors know that it takes more than an apple a day? Impact of formal nutrition training on family medicine residents’ nutrition knowledge, confidence, attitudes, and counselling abilities: a singl...
Background Malnutrition and poor dietary intake are major health challenges today. There are well-established benefits of nutrition interventions, but a lack of formalized nutrition training in medica...
bmcmededuc.biomedcentral.com
November 5, 2025 at 8:11 PM
Reposted by Dr. Todd Ewing PhD.
🧵1/6
📢 New meta-analysis shows lifestyle changes + GLP-1RAs lead to major weight loss & biomarker gains!
🔗 www.linkedin.com/feed/update/...

🌐 #GLP1 #DHPSP @hipecsurvivor.bsky.social @martinbue.bsky.social @shawneexo.bsky.social @holyunknown.bsky.social @alisyngayle.bsky.social @ustinoff.bsky.social
November 4, 2025 at 12:01 PM
Reposted by Dr. Todd Ewing PhD.
🧵 [3/6]
🩺 Cardiometabolic boost: lower blood pressure, HbA1c, cholesterol with GLP-1RA + lifestyle combo.

🌐 #CardioHealth #Diabetes #GLP1RA @manjeet786.bsky.social @alfredodistefano.bsky.social @nicksevillaz.bsky.social @spatzlhirn.bsky.social @ewingt-phd.bsky.social
November 4, 2025 at 12:03 PM
#heart health linked to #gut health via dietary #fiber

www.acc.org/Latest-in-Ca...

— feeds good gut bacteria
— lowers inflammation, cholesterol, blood sugar
— lowers cholesterol, BP, body weight
— 25-38 g fiber/d from fruits, vegetables, legumes, whole grains

#cardiovascular #diet #longevity
November 3, 2025 at 4:48 AM
Healthy #aging linked to increased #autophagy efficiency

www.lifespan.io/news/mainten...

— greater autophagy in older adults may be result of larger amount of damaged material
— autolysosomes more heterogenous & may be less resilient to stress

via @lifespanio.bsky.social
#science 🧪
Maintenance Stays Efficient in Healthy Older People’s Cells
Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. […]
www.lifespan.io
November 1, 2025 at 7:44 PM
Researchers @uarizona.bsky.social uncover glucagon role in #aging & #longevity

research.arizona.edu/news/u-scien...

— glucagon critical for healthspan stimulated by calorie restriction
— glucagon agonism in aging mice suppresses pathways that accelerate aging

#health #science #research 🧪
U of A scientists link calorie restriction, glucagon, healthy aging
A team from the Division of Endocrinology found that treatment with glucagon may induce similar metabolic benefits as caloric restriction, potentially slowing aging.
research.arizona.edu
November 1, 2025 at 7:11 PM
Iranian researchers describe how #exercise protects #pancreas beta cells from type 2 #diabetes

link.springer.com/article/10.1...

— incr NAD⁺ levels, AMPK, SIRT1
— decr mTOR

Improving:

— autophagy
— oxidative stress
— mitochondrial function
— β-cell mass & function

🧪 #health #science #research
The role of the SIRT1 and mTOR pathways in exercise-induced β-cell senescence reduction in type 2 diabetes mellitus - Cellular and Molecular Life Sciences
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance, chronic hyperglycemia, and pancreatic β-cell dysfunction, driven in part by cellular senescence and chronic inflammation. The si...
link.springer.com
November 1, 2025 at 4:27 AM
Longevity researcher Dr. Barzilai shares his thoughts on the field

time.com/7330284/agin...

— Optimize sleep, exercise, diet, social connectivity
— Intermittent fast 16 hours every day
— lost some weight
— gained muscle
— lost the fogginess during the day
How to Die Young at a Very Old Age
Longevity researcher Nir Barzilai shares how interfering with aging could prevent myriad diseases.
time.com
November 1, 2025 at 3:48 AM
Reposted by Dr. Todd Ewing PhD.
"[W]hat else could explain why some people feel better after going gluten-free? Such a change in the diet also reduces high-FODMAP foods and ultra-processed products, encourages mindful eating and offers a sense of control. All these can improve our wellbeing."
October 30, 2025 at 7:12 AM
#Gluten sensitivity may actually be FODMAP sensitivity

theconversation.com/your-gluten-...

#glutenfree risks:

> 139% more expensive
> lower in fiber & key nutrients
> reduces diversity in diet
> alters gut microbes
> reinforces anxiety about eating

🧪 #health #science #diet
Your gluten sensitivity might be something else entirely, new study shows
A new study shows gluten itself is rarely the cause of gut problems, whatever people think. But symptoms are real. So what’s really going on?
theconversation.com
October 30, 2025 at 1:02 AM
Reposted by Dr. Todd Ewing PhD.
October 25, 2025 at 6:49 AM
#mRNA #vaccine appears to boost anti #cancer treatment!

www.nature.com/articles/d41...

— Cancer patients treated with checkpoint inhibitors show stronger anti-tumor immunity if had COVID19 mRNA vaccine

— Vaccine activates immune system throughout entire body including inside the tumor

#science 🧪
People with some cancers live longer after a COVID vaccine
mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.
www.nature.com
October 23, 2025 at 8:36 PM
Egyptian researchers observe #lipoic #acid supplementation reduces #oxidative #stress in adolescents with type 1 #diabetes

www.sciencedirect.com/science/arti...

— randomized controlled trial
— 25 receive 300 mg/d ALA vs 25 placebo
— at 3 months, lower serum HbA1c & oxidation biomarkers

#science 🧪
The role of oral alpha-lipoic acid as an adjuvant antioxidant therapy in diabetic nephropathy among children and adolescents with type 1 diabetes: a randomized controlled trial
Evaluate the oxidant-antioxidant balance and the efficacy of Alpha-lipoic acid (ALA) as an adjuvant therapy for diabetic nephropathy (DN) among indivi…
www.sciencedirect.com
October 23, 2025 at 2:42 AM
Worldwide assessment of #air #pollution attributes

— exposure to fine particulate matter (PM₂․₅), nitrogen oxides, traffic-related pollutants
— 28% of dementia deaths
— 7.9 million deaths from all causes
— 610,000 deaths babies under 1 yo

healthpolicy-watch.news/air-pollutio...
Air Pollution-Related Dementia Kills Over 625,000 People A Year - Health Policy Watch
From killing over 600,000 elderly from dementia to an almost equal number of infants under the age of one-year, air pollution’s impact on young and old is
healthpolicy-watch.news
October 22, 2025 at 11:59 PM
Australian researchers discover how #pregnancy & #breastfeeding reduces risk of #breast #cancer

www.nature.com/articles/d41...

Involution of breast after weaning induces:

— older, damaged cells cleared out
— new cells created
— specialized T cells take residency for up to 50 years!

#science 🧪
Breastfeeding boosts immune cells that protect against breast cancer
The protective, long-lived T cells can persist for decades after a woman gives birth.
www.nature.com
October 21, 2025 at 6:57 PM
Here's a nice review of #circadian #nutrition

jhpn.biomedcentral.com/articles/10....

Time-restricted feeding:

— Consume bulk of calories earlier in the day
— Avoid late-night eating

Associated with improvements in:

— insulin sensitivity
— weight regulation
— cardiometabolic health

#health
Circadian nutrition and obesity: timing as a nutritional strategy - Journal of Health, Population and Nutrition
Background The global prevalence of obesity and metabolic disorders has reached critical levels, with over 1 billion individuals affected as of 2024. Traditional dietary strategies focusing on caloric...
jhpn.biomedcentral.com
October 17, 2025 at 10:52 PM
Reposted by Dr. Todd Ewing PhD.
CalRx® Insulin costs $11/pen
CalRx® Insulin costs $11/pen
CalRx® Insulin costs $11/pen
CalRx® Insulin costs $11/pen
CalRx® Insulin costs $11/pen

Available starting January 1, 2026.
October 17, 2025 at 3:44 PM
Japanese researchers observe NRF2 is potent anti-#inflammation target

www.nature.com/articles/s41...

In #mouse model of multiple organ dysfunction syndrome #MODS model, NRF2 activation caused:

— decr. inflammatory cytokines
— incr. blood flow, kidney & liver function
— incr. survival

#science 🧪
CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction via inflammatory pathway inhibition - Scientific Reports
Scientific Reports - CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction via inflammatory pathway inhibition
www.nature.com
October 17, 2025 at 5:46 PM