Ewan Harrison
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ewanharrison.bsky.social
Ewan Harrison
@ewanharrison.bsky.social
Microbiologist at the Wellcome Sanger Institute and University of Cambridge.
Overall, the data identifies a number of new genes and metabolic pathways likely to be critical in S. aureus colonisation (its primary lifestyle) that now require further investigation.
January 13, 2025 at 1:06 PM
We reveal that genes involved in nitrogen metabolism showed the strongest signal of adaption. As well as antibiotic resistance, riboflavin biosynthesis and quorum sensing regulation (amongst others).
January 13, 2025 at 1:06 PM
To understand the selective pressures that S. aureus experiences during colonisation, we analysed ~7000 S. aureus genomes from ~1500 individuals to identify protein altering mutations that were enriched.
January 13, 2025 at 1:06 PM