Ester Marina-Zárate
@estermz.bsky.social
Postdoc at @profshanecrotty.bsky.social lab | PhD Almudena Ramiro lab | Germinal center biology, B and Tfh cells
Happy to share our latest work! This study would not have been possible without the amazing Crotty Lab team, our collaborators at the Scripps CHAVD HIV vaccine consortia, and crucial support from NIH funding. Grateful to be part of this effort!
In our latest study in @cp-immunity.bsky.social, we followed dynamics of vaccine-specific Tfh cells for 60+ weeks after immunization.
authors.elsevier.com/a/1m3mV3qNrU...
We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.
authors.elsevier.com/a/1m3mV3qNrU...
We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.
November 12, 2025 at 8:05 PM
Happy to share our latest work! This study would not have been possible without the amazing Crotty Lab team, our collaborators at the Scripps CHAVD HIV vaccine consortia, and crucial support from NIH funding. Grateful to be part of this effort!
Reposted by Ester Marina-Zárate
Vaccine-specific Tfh undergo robust early expansion, sustained proliferation, months-long persistence w/o exhaustion, and functional specialization associated w/ enhanced germinal centers & humoral immunity@cp-immunity.bsky.social @profshanecrotty.bsky.social
www.cell.com/immunity/ful... @lji.org
www.cell.com/immunity/ful... @lji.org
November 9, 2025 at 10:29 PM
Vaccine-specific Tfh undergo robust early expansion, sustained proliferation, months-long persistence w/o exhaustion, and functional specialization associated w/ enhanced germinal centers & humoral immunity@cp-immunity.bsky.social @profshanecrotty.bsky.social
www.cell.com/immunity/ful... @lji.org
www.cell.com/immunity/ful... @lji.org
Reposted by Ester Marina-Zárate
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org
@scienceimmuno.bsky.social @lji.org
Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.
www.science.org
October 20, 2025 at 2:42 PM
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org
@scienceimmuno.bsky.social @lji.org
Reposted by Ester Marina-Zárate
After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people.
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models
An HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models.
www.science.org
July 30, 2025 at 7:15 PM
After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people.
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ester Marina-Zárate
In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans
Seasonal influenza vaccines are most frequently delivered as intramuscular inactivated vaccines which elicit systemic responses against the immunodominant hemagglutinin (HA) head domain. An intranasal...
www.biorxiv.org
July 21, 2025 at 2:48 PM
In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ester Marina-Zárate
One of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper…
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Diverse priming outcomes under conditions of very rare precursor B cells
B cells that give rise to neutralizing antibody responses can be extremely rare in
the naive B cell repertoire. Madden et al. show that delivery strategy and adjuvant
selection affect the recruitment ...
www.cell.com
April 7, 2025 at 1:50 PM
One of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper…
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social
www.cell.com/immunity/ful...