Yes that is very cool! I think that nucleotide chirality might be one of the natural pressures leading to our world with predominantly L-proteins. Fun to speculate, hard to test 😅

No just with the peptides. I think quite hard (or expensive!) to obtain a full protein in D-amino acids, but it would be sooooo cool to do and really a dream experiment especially if it could be 15N labelled too!

Thanks Kresten!

I’ve been so thrilled and honoured to be a part of this work alongside Amanda and @bbkrage.bsky.social as well as all of the other authors. And so thankful for funding of course from MSC Actions 🇪🇺

It seems there is a grey zone in which interactions with some disorder can still occur regardless of chirality. What does this mean for biochemical ancient history? Why did we end up in a world that is strictly made up of left handed proteins when these interactions can occur???

Turns out, chirality doesn’t matter at all in a completely disordered interaction. What about interactions that are a little bit disordered? Even so, a weaker interaction still occurs. This shocked us because it seems common sense that ANY structure would preclude interaction

@danirabaiotti.bsky.social hello could i be added to the feed 🧪 biochem/neuroscience person over here 🧠