The pandemics of respiratory viruses pose a worldwide public health problem and bio-safety threat. Therefore, the development of high-throughput and accurate infection models is crucial for elucidatin...

Infectious respiratory diseases are common epidemics that often exhibit phased outbreaks, increasing the healthcare burden. Past research models for t…

Viral diseases persistently threaten global health systems, causing substantial morbidity, mortality, and socioeconomic burdens. A comprehensive understanding of virus-host interactions is essential f...

Klebsiella pneumoniae (K. pneumoniae) has become a serious global health concern due to its rising virulence and antibiotic resistance. As one of the …

ObjectiveGiven the increasing prevalence of multidrug-resistant pathogens and the diminishing efficacy of conventional antibiotics, this study explores the p...

In this study, we developed novel lung organoid-on-chip models that elucidate differential human tissue response to various strains of respiratory pathogens: Streptococcus pneumoniae and SARS-CoV-2. W...

Airway-on-chip and alveolus-on-chip models using induced-pluripotent-stem-cell-derived lung progenitor cells show innate immune responses to common viruses.

Respiratory syncytial virus (RSV) is a seasonal respiratory pathogen that primarily affects young children, potentially causing severe lower respiratory tract disease. Despite the high disease burden,...

Background The nasal epithelium, as part of a continuous and integrated airway epithelium, provides a more accessible sample source than the bronchial epithelium. However, the similarities and differe...

BackgroundPneumonia is considered one of the most important causes of morbidity and mortality in the world. Bacterial and viral pneumonia share many similar ...

Summary: A humanized lung-on-a-chip model reveals early immune responses to Mycobacterium fortuitum infection, offering new insights into non-tuberculous mycobacteria pathogenesis relevant for drug di...

Bacterial pneumonia poses a significant challenge to public health, often leading to antibiotic treatment failure. Enhancing innate immunity represents a promising adjunctive strategy to conventional ...

In their 1987 community-acquired pneumonia (CAP) guidelines, the British Thoracic Society recommended amoxicillin with or without erythromycin (or tetracycline) in all admitted patients, with the coverage for Legionella being mandatory in seriously ill patients [1]. They also recommended intravenous flucloxacillin when Staphylococcus aureus was suspected and gentamicin or ceftazidime if a Gram-negative agent was suspected. This guideline, now more than 30 years old, also emphasised the need to identify critically ill patients based on objective physiological criteria so they could receive intensive care support, recommended obtaining culture specimens when possible and stated that antibiotics should be started immediately upon diagnosis. All of these 1987 recommendations were based on clinical studies on the aetiology of pneumonia, analysis of the predictors of outcome from pneumonia from clinical studies and a series of observational studies comparing outcomes of different antibiotic regimens in the prior three decades.

Xenotransplantation is increasingly touted as the solution to the organ crisis. Some bioethicists, however, have raised concerns about xenotransplantation's implications for health justice and animal....