Erinne Ong
@erinneuro.bsky.social
PhD student @dkfz.bsky.social • interested in neuro-glia-tumor interactions and the circuitry of brain cancer networks 🧠 • 🇵🇭 in 🇩🇪 • science communication, mentorship, & outreach
Very glad to have contributed to this during my master's! We hope the work resonates as something worth considering within the AD community or more broadly among those using transgenic models.
For a full "bluetorial" please see @aosasmita.bsky.social's excellent breakdown:
bsky.app/profile/aosa...
For a full "bluetorial" please see @aosasmita.bsky.social's excellent breakdown:
bsky.app/profile/aosa...
Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.
Thread below: (1/11)
Thread below: (1/11)
Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease
The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying
cerebral plaque burden depending on the parental source of the transgene. Mice inheriting
the transgene paternally...
www.cell.com
January 20, 2025 at 5:19 PM
Very glad to have contributed to this during my master's! We hope the work resonates as something worth considering within the AD community or more broadly among those using transgenic models.
For a full "bluetorial" please see @aosasmita.bsky.social's excellent breakdown:
bsky.app/profile/aosa...
For a full "bluetorial" please see @aosasmita.bsky.social's excellent breakdown:
bsky.app/profile/aosa...