Hi Jochen! Using Glycounter (from RRG), we can classify MS/MS scans as 'likely glyco' from the presence of >8 oxonium ions. Here, NP+MAX yields around 60% of MS/MS scans with oxonium ions whereas neat plasma (NP0) has 4%.

Can nanoparticles help us probe the glycoproteome?

The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc.

Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...

Had an amazing time at the Glycobiology Gordon Research Seminar and Conference in Italy! 🇮🇹 As a first-time attendee, I appreciated meeting so many incredible scientists from across the world. We spent the days talking about carbohydrates, and the nights eating them. 🍝 #Glycobiology #Glycotime

The final chapter of my PhD thesis is officially published!😄 It's a true reflection of collaborative research and I can't thank my PhD supervisor, Clarissa Melo Czekster, enough. Of course, the figures feature the most amount of pink probably seen in a research journal so please enjoy! rdcu.be/d7owS

Curious about artificial deamidation? Check out our updated preprint! tinyurl.com/ms6fz3sn
Now with PBS as a 6th buffer + new K562 data + N-terminal Q -> pyro-Glu investigations.

Take home message: Zwitterionic buffers like HEPES minimize unwanted artifacts!

@riley-research.bsky.social