Elphege Nora Lab at UCSF
@elphegenoralab.bsky.social
Our laboratory seeks to understand how chromosome structure relates to genome functions
29 / and this one illustrates the dramatic differences in loop dynamics after depleting
NIPBL (slow rate, normal lifetime)
WAPL (very high lifetime)
PDS5 (high lifetime, high rate)
NIPBL (slow rate, normal lifetime)
WAPL (very high lifetime)
PDS5 (high lifetime, high rate)
August 19, 2025 at 9:24 PM
29 / and this one illustrates the dramatic differences in loop dynamics after depleting
NIPBL (slow rate, normal lifetime)
WAPL (very high lifetime)
PDS5 (high lifetime, high rate)
NIPBL (slow rate, normal lifetime)
WAPL (very high lifetime)
PDS5 (high lifetime, high rate)
28/ and some movies!
This one illustrates the difference in loop dynamics between high lifetime v.s. high rate, at equal processivity.
LEFT - High lifetime: loops take time to grow but remain for very long
RIGHT - High rate: loops grow super fast but eventually dissociate to reform
This one illustrates the difference in loop dynamics between high lifetime v.s. high rate, at equal processivity.
LEFT - High lifetime: loops take time to grow but remain for very long
RIGHT - High rate: loops grow super fast but eventually dissociate to reform
August 19, 2025 at 9:21 PM
28/ and some movies!
This one illustrates the difference in loop dynamics between high lifetime v.s. high rate, at equal processivity.
LEFT - High lifetime: loops take time to grow but remain for very long
RIGHT - High rate: loops grow super fast but eventually dissociate to reform
This one illustrates the difference in loop dynamics between high lifetime v.s. high rate, at equal processivity.
LEFT - High lifetime: loops take time to grow but remain for very long
RIGHT - High rate: loops grow super fast but eventually dissociate to reform
26/ This was a hand in hand collaboration between experimentalists in our group led by @rinishah.bsky.social , and physicists in @gfudenberg.bsky.social ’s lab led by Max Tortora, with help from @nesslfy.bsky.social in @lucagiorgetti.bsky.social ’s lab.
A fun thank-you video for reading that far:
A fun thank-you video for reading that far:
August 16, 2025 at 2:40 AM
26/ This was a hand in hand collaboration between experimentalists in our group led by @rinishah.bsky.social , and physicists in @gfudenberg.bsky.social ’s lab led by Max Tortora, with help from @nesslfy.bsky.social in @lucagiorgetti.bsky.social ’s lab.
A fun thank-you video for reading that far:
A fun thank-you video for reading that far: