Elia Mascolo
@eliamascolo.bsky.social
I love studying evolution through the lens of theoretical and computational biology. Math enthusiast and amateur jazz piano player.
https://eliamascolo.github.io/
https://eliamascolo.github.io/
Two years ago we published about what we named "lytic deferment" in bacteriophages (doi.org/10.3389/fmic...). The concept is re-discussed in this recent review by Casters et al. "Phage transmission strategies: are phages framing their host?" doi.org/10.1016/j.mi...
Food for thought.
🧬🦠🔬
Food for thought.
🧬🦠🔬
July 9, 2024 at 7:38 PM
Two years ago we published about what we named "lytic deferment" in bacteriophages (doi.org/10.3389/fmic...). The concept is re-discussed in this recent review by Casters et al. "Phage transmission strategies: are phages framing their host?" doi.org/10.1016/j.mi...
Food for thought.
🧬🦠🔬
Food for thought.
🧬🦠🔬
Case 3 is particularly convincing because the site came out quite different from the consensus. It's not the classical CTGT-n8-ACAG, but AF3 predicts that the dimer binds there. AF3 can propose more than one model, but I was only looking at the first proposed. If I consider 7/
May 10, 2024 at 4:24 PM
Case 3 is particularly convincing because the site came out quite different from the consensus. It's not the classical CTGT-n8-ACAG, but AF3 predicts that the dimer binds there. AF3 can propose more than one model, but I was only looking at the first proposed. If I consider 7/
In 8/8 cases, the TF complex is perfect, and targets DNA using correctly the DNA binding domains. In 4/8 cases, the binding occurs precisely on my "randomized" LexA sites. Uppercase: from PWM; lowercase: random; underlined red: binding expected; highlighted yellow: bound. 6/
May 10, 2024 at 4:23 PM
In 8/8 cases, the TF complex is perfect, and targets DNA using correctly the DNA binding domains. In 4/8 cases, the binding occurs precisely on my "randomized" LexA sites. Uppercase: from PWM; lowercase: random; underlined red: binding expected; highlighted yellow: bound. 6/
They isolated the MulchMansion-MulchRoom system, relatives of the MindFlayer-MiniFlayer system. Their satellite (MulchRoom) is temperate, as you would expect from a satellite (it should be able to lay dormant until the helper enters the host). Instead, MiniFlayer lacks the lysogeny module. [4/n]
November 12, 2023 at 4:57 AM
They isolated the MulchMansion-MulchRoom system, relatives of the MindFlayer-MiniFlayer system. Their satellite (MulchRoom) is temperate, as you would expect from a satellite (it should be able to lay dormant until the helper enters the host). Instead, MiniFlayer lacks the lysogeny module. [4/n]