Ed Chuong
@edchuong.bsky.social
Assistant Professor at the University of Colorado Boulder - Genome regulation, Transposons, Immunity - https://chuonglab.colorado.edu
Pinned
Ed Chuong
@edchuong.bsky.social
· Dec 12
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Reposted by Ed Chuong
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 21, 2025 at 3:20 PM
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
Reposted by Ed Chuong
Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...
A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.
www.science.org
July 21, 2025 at 1:51 PM
Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...
Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado!
jobs.colorado.edu/jobs/JobDeta...
🧪🧬 #TESky #interferosky
jobs.colorado.edu/jobs/JobDeta...
🧪🧬 #TESky #interferosky
July 17, 2025 at 7:36 PM
Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado!
jobs.colorado.edu/jobs/JobDeta...
🧪🧬 #TESky #interferosky
jobs.colorado.edu/jobs/JobDeta...
🧪🧬 #TESky #interferosky
Reposted by Ed Chuong
Pls. share widely
Calling all transposon fans & lovers of genetic innovation
MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025
→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)
submit abstract by July 29
Calling all transposon fans & lovers of genetic innovation
MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025
→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)
submit abstract by July 29
⏰ Abstract deadline for 'The mobile genome' is 29 July!
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
July 16, 2025 at 8:43 AM
Pls. share widely
Calling all transposon fans & lovers of genetic innovation
MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025
→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)
submit abstract by July 29
Calling all transposon fans & lovers of genetic innovation
MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025
→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)
submit abstract by July 29
Reposted by Ed Chuong
Ok fine I'll listen to the Bhattacharya/Huberman interview amd share my notes
a woman wearing a protective suit with experian written on it
Alt: a woman wearing a protective suit with experian written on it
media.tenor.com
June 9, 2025 at 7:09 PM
Ok fine I'll listen to the Bhattacharya/Huberman interview amd share my notes
Reposted by Ed Chuong
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound
of TE-derived sequences repurposed for organismal function. ...
www.pnas.org
April 30, 2025 at 10:45 AM
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Reposted by Ed Chuong
If no single piece of the original ship remains in the current ship, is the ship still the Ship of Theseus?
And if one percent of all my body's cells get replaced every single day, is it really me who, two months ago, accepted your review request?
And if one percent of all my body's cells get replaced every single day, is it really me who, two months ago, accepted your review request?
March 20, 2025 at 6:00 AM
If no single piece of the original ship remains in the current ship, is the ship still the Ship of Theseus?
And if one percent of all my body's cells get replaced every single day, is it really me who, two months ago, accepted your review request?
And if one percent of all my body's cells get replaced every single day, is it really me who, two months ago, accepted your review request?
Reposted by Ed Chuong
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
2025 Study section tracking
docs.google.com
February 24, 2025 at 4:17 PM
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
Reposted by Ed Chuong
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Graduate Reductions Across Biomedical Sciences (2025)
docs.google.com
February 22, 2025 at 1:23 PM
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Reposted by Ed Chuong
PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n
CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1
February 5, 2025 at 6:34 PM
PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n
Reposted by Ed Chuong
Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵
A short thread to highlight some of our findings 🧵
January 20, 2025 at 8:29 PM
Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵
A short thread to highlight some of our findings 🧵
Reposted by Ed Chuong
Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium
Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...
rdcu.be
January 10, 2025 at 5:22 AM
Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
Reposted by Ed Chuong
I'm looking for a postdoc to join my fantastic team at the NIH in Bethesda, MD. Great resources. Competitive salary. www.training.nih.gov/jobs/pdf-mb-...
Postdoc: Molecular Biology/Genetics/Developmental Biology/Evolution/Computational Biology
www.training.nih.gov
January 8, 2025 at 7:06 PM
I'm looking for a postdoc to join my fantastic team at the NIH in Bethesda, MD. Great resources. Competitive salary. www.training.nih.gov/jobs/pdf-mb-...
Reposted by Ed Chuong
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
December 26, 2024 at 5:24 PM
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Reposted by Ed Chuong
Check out this thread on the latest work from our lab, led by @emilykibby.bsky.social ! Here we used the power of computationally predicting protein-protein interactions to understand how a bacterial antiphage system senses infection.
I’m so excited to share that some of my grad work in the @aaronwhiteley lab is now available on bioRxiv! We used an AlphaFold-multimer screen to uncover how a bacterial NLR-related proteins senses multiple phage-encoded proteins to confer phage protection. Link: www.biorxiv.org/content/10.1...
A bacterial NLR-related protein recognizes multiple unrelated phage triggers to sense infection
Immune systems must rapidly sense viral infections to initiate antiviral signaling and protect the host. Bacteria encode >100 distinct viral (phage) defense systems and each has evolved to sense cruci...
www.biorxiv.org
December 19, 2024 at 4:09 AM
Check out this thread on the latest work from our lab, led by @emilykibby.bsky.social ! Here we used the power of computationally predicting protein-protein interactions to understand how a bacterial antiphage system senses infection.
Reposted by Ed Chuong
First #bluetorial. 🎉🎉 We’re very happy to share our latest biorxiv #preprint, just in time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes. #TEsky #evosky #Celegans
Short 🧵 with highlights.
Short 🧵 with highlights.
December 19, 2024 at 12:35 PM
First #bluetorial. 🎉🎉 We’re very happy to share our latest biorxiv #preprint, just in time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes. #TEsky #evosky #Celegans
Short 🧵 with highlights.
Short 🧵 with highlights.
Reposted by Ed Chuong
#NotOnlyParasites! 2 Cell papers by @edchuong.bsky.social lab & Amigorena lab demonstrate that transposable elements #TEs can exonize giving rise to functional (often shorter) proteins with distinct functions: eg a decoy short IFNAR2 that inhibits #interferon signaling! www.cell.com/cell/fulltex...
Transposable element exonization generates a reservoir of evolving and functional protein isoforms
Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.
www.cell.com
December 12, 2024 at 5:36 PM
#NotOnlyParasites! 2 Cell papers by @edchuong.bsky.social lab & Amigorena lab demonstrate that transposable elements #TEs can exonize giving rise to functional (often shorter) proteins with distinct functions: eg a decoy short IFNAR2 that inhibits #interferon signaling! www.cell.com/cell/fulltex...
Reposted by Ed Chuong
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @edchuong.bsky.social
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @edchuong.bsky.social
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
December 12, 2024 at 4:38 PM
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @edchuong.bsky.social
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @edchuong.bsky.social
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
December 12, 2024 at 6:57 PM
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Reposted by Ed Chuong
What better place than the city of lights to make my transposition to 🦋. Look at all that blue sky!
December 4, 2024 at 5:08 PM
What better place than the city of lights to make my transposition to 🦋. Look at all that blue sky!
Reposted by Ed Chuong
Scraping who is on the platform working on #TransposableElements or other types of #RepetitiveDNA
Have fun!
go.bsky.app/7t5GQAP
Have fun!
go.bsky.app/7t5GQAP
November 10, 2024 at 10:47 PM
Scraping who is on the platform working on #TransposableElements or other types of #RepetitiveDNA
Have fun!
go.bsky.app/7t5GQAP
Have fun!
go.bsky.app/7t5GQAP
Excited to share our latest preprint on transposon exonization and human immune signaling! We found that an Alu element forms a cryptic but highly expressed splice variant of the interferon receptor IFNAR2, which functions as an interferon decoy receptor that regulates interferon signaling.
Regulation of interferon signaling by transposon exonization
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
September 15, 2023 at 6:51 PM
Excited to share our latest preprint on transposon exonization and human immune signaling! We found that an Alu element forms a cryptic but highly expressed splice variant of the interferon receptor IFNAR2, which functions as an interferon decoy receptor that regulates interferon signaling.
Hi, I'm Ed 👋!
I'm an Assistant Professor at CU Boulder, where I study how transposons influence immune function and evolution. Posts on science, DEI, and pics including my dog and the blue skies of the American southwest
#AcademicSky #evosky
I'm an Assistant Professor at CU Boulder, where I study how transposons influence immune function and evolution. Posts on science, DEI, and pics including my dog and the blue skies of the American southwest
#AcademicSky #evosky
September 10, 2023 at 7:35 PM
Hi, I'm Ed 👋!
I'm an Assistant Professor at CU Boulder, where I study how transposons influence immune function and evolution. Posts on science, DEI, and pics including my dog and the blue skies of the American southwest
#AcademicSky #evosky
I'm an Assistant Professor at CU Boulder, where I study how transposons influence immune function and evolution. Posts on science, DEI, and pics including my dog and the blue skies of the American southwest
#AcademicSky #evosky