Department of Translational Genomics - University of Cologne
@dtg-cologne.bsky.social
www.translational-genomics.de
🗝️ #DynaTag can reveal nuanced TF occupancy behaviour and shed light on transcriptional regulation in health and disease. In small cell lung cancer #SCLC PDX models, it uncovered surprising gain-of-function p53, FOXA1 & MYC activity post-chemotherapy – not for ASCL1, NEUROD1, POU2F3 or YAP1 (5/7)
July 28, 2025 at 9:08 AM
How is DynaTag better than CUT&Tag?
⚡Preserves weak/transient TF binding without signal loss
⚡Better signal-to-noise & resolution
⚡Works for all TFs (high and low DNA-binding affinity) & histone marks
⚡Low-input needed, bulk or single-cell, scalable to multi-cellular systems (4/7)
⚡Preserves weak/transient TF binding without signal loss
⚡Better signal-to-noise & resolution
⚡Works for all TFs (high and low DNA-binding affinity) & histone marks
⚡Low-input needed, bulk or single-cell, scalable to multi-cellular systems (4/7)
July 28, 2025 at 9:08 AM
How is DynaTag better than CUT&Tag?
⚡Preserves weak/transient TF binding without signal loss
⚡Better signal-to-noise & resolution
⚡Works for all TFs (high and low DNA-binding affinity) & histone marks
⚡Low-input needed, bulk or single-cell, scalable to multi-cellular systems (4/7)
⚡Preserves weak/transient TF binding without signal loss
⚡Better signal-to-noise & resolution
⚡Works for all TFs (high and low DNA-binding affinity) & histone marks
⚡Low-input needed, bulk or single-cell, scalable to multi-cellular systems (4/7)
🤔 How to capture nuanced TF-DNA interactions?
💡 Enter #DynaTag: ‘Dynamic targets and Tagmentation’ captures transient TF-DNA interactions that standard CUT&Tag misses.
The trick? Sample prep under physiological salt stabilizes specific interactions without promoting untargeted tagmentation 🧂 (3/7)
💡 Enter #DynaTag: ‘Dynamic targets and Tagmentation’ captures transient TF-DNA interactions that standard CUT&Tag misses.
The trick? Sample prep under physiological salt stabilizes specific interactions without promoting untargeted tagmentation 🧂 (3/7)
July 28, 2025 at 9:07 AM
🤔 How to capture nuanced TF-DNA interactions?
💡 Enter #DynaTag: ‘Dynamic targets and Tagmentation’ captures transient TF-DNA interactions that standard CUT&Tag misses.
The trick? Sample prep under physiological salt stabilizes specific interactions without promoting untargeted tagmentation 🧂 (3/7)
💡 Enter #DynaTag: ‘Dynamic targets and Tagmentation’ captures transient TF-DNA interactions that standard CUT&Tag misses.
The trick? Sample prep under physiological salt stabilizes specific interactions without promoting untargeted tagmentation 🧂 (3/7)
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
The newly developed DynaTag by Robert and his lab @epistrucstab.bsky.social is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
The newly developed DynaTag by Robert and his lab @epistrucstab.bsky.social is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
July 28, 2025 at 9:04 AM
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
The newly developed DynaTag by Robert and his lab @epistrucstab.bsky.social is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
The newly developed DynaTag by Robert and his lab @epistrucstab.bsky.social is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
On behalf of the conference chair Caroline Dive and the organizing committee Reinhard Büttner, Roman Thomas, Jürgen Wolf:
We are delighted to announce the 3rd Cologne Conference on Lung Cancer (CCLC), June 26th – 27th, 2025 at the Maritim Hotel in Cologne.
Registration is now open!! cologne-clc.com
We are delighted to announce the 3rd Cologne Conference on Lung Cancer (CCLC), June 26th – 27th, 2025 at the Maritim Hotel in Cologne.
Registration is now open!! cologne-clc.com
March 10, 2025 at 11:13 AM
On behalf of the conference chair Caroline Dive and the organizing committee Reinhard Büttner, Roman Thomas, Jürgen Wolf:
We are delighted to announce the 3rd Cologne Conference on Lung Cancer (CCLC), June 26th – 27th, 2025 at the Maritim Hotel in Cologne.
Registration is now open!! cologne-clc.com
We are delighted to announce the 3rd Cologne Conference on Lung Cancer (CCLC), June 26th – 27th, 2025 at the Maritim Hotel in Cologne.
Registration is now open!! cologne-clc.com