Philip Dunne
@drpipdunne.bsky.social
Phenotypic plasticity in colorectal cancer. Group leader at QUB Belfast and CRUK Scotland Institute.
CRUK-SI: https://tinyurl.com/5fr9n2ew
QUB: https://tinyurl.com/4b68vf56
CRUK-SI: https://tinyurl.com/5fr9n2ew
QUB: https://tinyurl.com/4b68vf56
Reposted by Philip Dunne
And the original publication is here:
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibronectin deposition and support metastatic niche ...
share.google
July 28, 2025 at 3:21 PM
And the original publication is here:
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...
Reposted by Philip Dunne
My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social
Please help to spread the word!
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Please help to spread the word!
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April 26, 2025 at 12:26 AM
Reposted by Philip Dunne
Members of IMPACT span wet-lab scientists, pathologists, bioinformaticians, patient involvement managers, image analysts, technicians, clinicians, students, project managers, and lecturers among others, to ensure a wide range of expertise and optimum resource management!
March 26, 2025 at 5:29 PM
Members of IMPACT span wet-lab scientists, pathologists, bioinformaticians, patient involvement managers, image analysts, technicians, clinicians, students, project managers, and lecturers among others, to ensure a wide range of expertise and optimum resource management!
Reposted by Philip Dunne
With 5 distinct research groups led by @joedwardswwcrc.bsky.social, Campbell Roxburgh, Nigel Jamieson, Colin Steele, and @mcsorleystephen.bsky.social, IMPACT provides a human tissue-based translational research infrastructure in Glasgow, in collaboration with @drpipdunne.bsky.social and Xiao Fu! 🤝
March 26, 2025 at 5:29 PM
With 5 distinct research groups led by @joedwardswwcrc.bsky.social, Campbell Roxburgh, Nigel Jamieson, Colin Steele, and @mcsorleystephen.bsky.social, IMPACT provides a human tissue-based translational research infrastructure in Glasgow, in collaboration with @drpipdunne.bsky.social and Xiao Fu! 🤝
Reposted by Philip Dunne
Congrats to @zanivanlab.bsky.social for this very interesting review: www.cell.com/cell-reports...
The tumor microenvironment is an ecosystem sustained by metabolic interactions
Cancer-associated fibroblasts and immune cells are known to interact within the tumor
microenvironment and influence each other to impact on tumor progression. Here, Kay
et al. discuss how they can al...
www.cell.com
March 23, 2025 at 6:30 AM
Congrats to @zanivanlab.bsky.social for this very interesting review: www.cell.com/cell-reports...