Ming Lee
@drmjlee.bsky.social
Cat dad. Sexual Health and HIV doctor. He/Him 🏳️🌈
LS-bNAbs were detectable in the gut up to 6m after a single dose, but tissue bNAbs exposurewere 7-8x lower compared to blood.
This long term viral control does not appear to be due to tissue persistence of LS-bNAbs.
This long term viral control does not appear to be due to tissue persistence of LS-bNAbs.
April 10, 2025 at 7:23 AM
LS-bNAbs were detectable in the gut up to 6m after a single dose, but tissue bNAbs exposurewere 7-8x lower compared to blood.
This long term viral control does not appear to be due to tissue persistence of LS-bNAbs.
This long term viral control does not appear to be due to tissue persistence of LS-bNAbs.
Of these group, some experienced rebound while bNAbs were still high, some when the bNAbs were below the 10ug/ml threshold (previously thought to be when bNAbs are no longer effective), and some people who remained fully suppressed despite no bNAbs on board.
April 10, 2025 at 7:23 AM
Of these group, some experienced rebound while bNAbs were still high, some when the bNAbs were below the 10ug/ml threshold (previously thought to be when bNAbs are no longer effective), and some people who remained fully suppressed despite no bNAbs on board.
As RIO and other groups have shown, bNAbs may be most promising as an immunotherapeutic intervention to enhance immun rasponsew, rather than as ART treatment. #CROI2025
March 12, 2025 at 7:58 PM
As RIO and other groups have shown, bNAbs may be most promising as an immunotherapeutic intervention to enhance immun rasponsew, rather than as ART treatment. #CROI2025
Reposted by Ming Lee
A real challenge in this field is being able to carefully examine brain and central nervous system tissues over time. People may consent to lumbar punctures but a (or multiple) brain biopsy is much more invasive. Studies like the Last Gift are truly amazing but only allow tissue study after death.
March 12, 2025 at 5:44 PM
A real challenge in this field is being able to carefully examine brain and central nervous system tissues over time. People may consent to lumbar punctures but a (or multiple) brain biopsy is much more invasive. Studies like the Last Gift are truly amazing but only allow tissue study after death.
Reposted by Ming Lee
You can find out more about the latest study developments at riotrial.org
RIO HIV Trial - Viral suppression off ART using dual bNAb therapy
RIO is looking at whether a new type of treatment, called bNAbs can keep viral load undetectable without antiretroviral treatment (ART)
riotrial.org
March 11, 2025 at 7:21 PM
You can find out more about the latest study developments at riotrial.org
Yes, we need more longer acting options!
March 11, 2025 at 5:55 PM
Yes, we need more longer acting options!