Ben Schumann
@drglycoben.bsky.social
Full Prof of Biochemistry at TU Dresden, visiting at The Crick & Imperial College. We are making next-generation chemical tools to understand glycans in biology. he/him
The entire paper is supported by (often sub-A resolution) crystal structure magic by @stephcrystallab.bsky.social and Andy Purkiss @crick.ac.uk. My favourite one is of the covalent linkage of WBC10 with Tyr211 - a thing of beauty! Next --> Application!
October 7, 2025 at 6:10 AM
The entire paper is supported by (often sub-A resolution) crystal structure magic by @stephcrystallab.bsky.social and Andy Purkiss @crick.ac.uk. My favourite one is of the covalent linkage of WBC10 with Tyr211 - a thing of beauty! Next --> Application!
In parallel, Will performed a covalent, sulfonyl fluoride-targeted fragment screen and found Tyr211 to be especially reactive. Because Tyr211 is around the same binding pocket for our non-covalent inhibitors, we decided to merge these chemotypes. And it worked!
October 7, 2025 at 6:10 AM
In parallel, Will performed a covalent, sulfonyl fluoride-targeted fragment screen and found Tyr211 to be especially reactive. Because Tyr211 is around the same binding pocket for our non-covalent inhibitors, we decided to merge these chemotypes. And it worked!
The human UDP-Gal-4-epimerase is important for cellular biosynthesis of UDP-Gal and UDP-GalNAc. Both are important precursors for glycosylation. GALE KO abrogates cellular levels of these metabolites. GALE plays a role in cancer (pubmed.ncbi.nlm.nih.gov/31908526/) - so we decided to drug it!
October 7, 2025 at 6:10 AM
The human UDP-Gal-4-epimerase is important for cellular biosynthesis of UDP-Gal and UDP-GalNAc. Both are important precursors for glycosylation. GALE KO abrogates cellular levels of these metabolites. GALE plays a role in cancer (pubmed.ncbi.nlm.nih.gov/31908526/) - so we decided to drug it!
It doesn't happen very often that you receive an award on the same day as your mentor. Congratulations to Peter Seeberger on winning the @rsc.org Khorana Award #glycotime! And I am very thankful to the amazing lab members, colleagues and mentors that led to winning the Norman Heatley Award!
May 13, 2025 at 11:53 AM
It doesn't happen very often that you receive an award on the same day as your mentor. Congratulations to Peter Seeberger on winning the @rsc.org Khorana Award #glycotime! And I am very thankful to the amazing lab members, colleagues and mentors that led to winning the Norman Heatley Award!
We had a blast at yesterday's @rsc.org Chemical Biology Symposium. Congratulations to Teresa and Freya who were awarded a prestigious poster prize!
May 13, 2025 at 11:44 AM
We had a blast at yesterday's @rsc.org Chemical Biology Symposium. Congratulations to Teresa and Freya who were awarded a prestigious poster prize!
Such an amazing symposium! Here with @davidsharp.bsky.social who presented his work on a modular approach to photoswitchable sugars - stay tuned on this! #glycotime
March 3, 2025 at 11:04 AM
Such an amazing symposium! Here with @davidsharp.bsky.social who presented his work on a modular approach to photoswitchable sugars - stay tuned on this! #glycotime
I am so excited about having been admitted as a Fellow of the Royal Society of Chemistry @rsc.org 🥳 this is only possible through the help of an amazing team, supportive mentors and the #glycotime field being just absolutely fantastic!
March 3, 2025 at 11:02 AM
I am so excited about having been admitted as a Fellow of the Royal Society of Chemistry @rsc.org 🥳 this is only possible through the help of an amazing team, supportive mentors and the #glycotime field being just absolutely fantastic!
There is a German saying: "All good things come in three". Big congratulations to our third PhD graduate, Beatriz Calle! Bea has been a jointly supervised with Ilaria Malanchi and produced a fantastic story on using chemical biology to unravel protein glycosylation in breast cancer...
November 16, 2024 at 2:00 PM
There is a German saying: "All good things come in three". Big congratulations to our third PhD graduate, Beatriz Calle! Bea has been a jointly supervised with Ilaria Malanchi and produced a fantastic story on using chemical biology to unravel protein glycosylation in breast cancer...
🥳🥳🥳 PhD done! Congratulations to Will Browne on his PhD defense *without corrections*!! Huge thanks to Gideon Davies and Alan Armstrong for being a fantastic examiner team. Just in time for the @thecrick.bsky.social Christmas party!
December 15, 2023 at 3:54 PM
🥳🥳🥳 PhD done! Congratulations to Will Browne on his PhD defense *without corrections*!! Huge thanks to Gideon Davies and Alan Armstrong for being a fantastic examiner team. Just in time for the @thecrick.bsky.social Christmas party!
At lab Xmas lunch yesterday, we said goodbye in style to
Dr Zhen Li who has been a fantastic team member for the last four years. All the best with your next steps! Then we embarked on an amazing scavenger hunt through the London Christmas lights.
Dr Zhen Li who has been a fantastic team member for the last four years. All the best with your next steps! Then we embarked on an amazing scavenger hunt through the London Christmas lights.
December 15, 2023 at 3:44 PM
At lab Xmas lunch yesterday, we said goodbye in style to
Dr Zhen Li who has been a fantastic team member for the last four years. All the best with your next steps! Then we embarked on an amazing scavenger hunt through the London Christmas lights.
Dr Zhen Li who has been a fantastic team member for the last four years. All the best with your next steps! Then we embarked on an amazing scavenger hunt through the London Christmas lights.
So proud of our PhD student Mia Zol-Hanlon who won the award for best presentation at the 89th Harden Conference in Proteoglycans! Here with Jerry Turnbull 😀 Glycotime!
October 31, 2023 at 10:35 AM
So proud of our PhD student Mia Zol-Hanlon who won the award for best presentation at the 89th Harden Conference in Proteoglycans! Here with Jerry Turnbull 😀 Glycotime!