Emily Goldberg
@dremilygoldberg.bsky.social
Immunologist, metabolism enthusiast. Assistant Professor. Woman in science
Northern lights visible in the bay area!
November 12, 2025 at 3:42 AM
Northern lights visible in the bay area!
Incredible sunset for tonight's ferry commute
October 31, 2025 at 1:26 AM
Incredible sunset for tonight's ferry commute
The sky is really putting on a show tonight
October 15, 2025 at 1:32 AM
The sky is really putting on a show tonight
This matches a bunch of data we generated showing that knocking down or inhibiting acyltransferases does not impact global protein lactylation levels. Read the paper (open access!) to get more detail about why we think this pathway is so interesting and physiologically relevant! And more to come!
August 20, 2025 at 7:28 PM
This matches a bunch of data we generated showing that knocking down or inhibiting acyltransferases does not impact global protein lactylation levels. Read the paper (open access!) to get more detail about why we think this pathway is so interesting and physiologically relevant! And more to come!
Cultured cells contain lactylated proteins but adding HDAC inhibitors reduces this. Importantly, this inhibition is independent of intracellular lactate or lactyl-CoA concentrations (thank you @mzspectrum.bsky.social for helping with this!). We uncoupled Kla from lactyl-CoA!
August 20, 2025 at 7:28 PM
Cultured cells contain lactylated proteins but adding HDAC inhibitors reduces this. Importantly, this inhibition is independent of intracellular lactate or lactyl-CoA concentrations (thank you @mzspectrum.bsky.social for helping with this!). We uncoupled Kla from lactyl-CoA!
We established biochemically that HDACs can indeed catalyze the lactylation of proteins. A lysine protection assay with fluorescent peptide also revealed the reaction can occur well within physiological lactate levels, making this basally more likely than the proposed lactyl-CoA mechanism
August 20, 2025 at 7:28 PM
We established biochemically that HDACs can indeed catalyze the lactylation of proteins. A lysine protection assay with fluorescent peptide also revealed the reaction can occur well within physiological lactate levels, making this basally more likely than the proposed lactyl-CoA mechanism
Thrilled to finally write up a little thread on our recent paper with @gburslem.bsky.social describing how HDACs reversibility contributes to protein lactylation!
www.jbc.org/article/S002...
www.jbc.org/article/S002...
August 20, 2025 at 7:28 PM
Thrilled to finally write up a little thread on our recent paper with @gburslem.bsky.social describing how HDACs reversibility contributes to protein lactylation!
www.jbc.org/article/S002...
www.jbc.org/article/S002...
July 19, 2025 at 5:25 PM
Super excited to share our newest story! We found that despite their well-known reliance on glucose, neutrophils also like lipids! Lipid uptake is induced by immune signals, and we think this is important in atherosclerosis and other lipotoxic metabolic diseases!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 15, 2025 at 1:32 PM
Super excited to share our newest story! We found that despite their well-known reliance on glucose, neutrophils also like lipids! Lipid uptake is induced by immune signals, and we think this is important in atherosclerosis and other lipotoxic metabolic diseases!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Please enjoy the tour of our new lab 🥹
Credit goes to our extremely resourceful PhD student
Credit goes to our extremely resourceful PhD student
June 5, 2025 at 10:22 PM
Please enjoy the tour of our new lab 🥹
Credit goes to our extremely resourceful PhD student
Credit goes to our extremely resourceful PhD student
I'm a laptop sticker person now
May 4, 2025 at 6:42 PM
I'm a laptop sticker person now
Last weekend someone saw my sign and asked "what's the NIH?" We had a great conversation about science, funding, clinical trials, and universities/academic science. Scientists, this is a reminder we can't duck and cover in the lab. We have to be visible and talking to people in our communities
April 23, 2025 at 3:20 PM
Last weekend someone saw my sign and asked "what's the NIH?" We had a great conversation about science, funding, clinical trials, and universities/academic science. Scientists, this is a reminder we can't duck and cover in the lab. We have to be visible and talking to people in our communities
Barely captured a whale's water spout!
April 11, 2025 at 1:33 AM
Barely captured a whale's water spout!
Real roller coaster day for US scientists. A powerful stand from Cory Booker while NIH and CDC were simultaneously being gutted.
We will NOT be quiet!
We will NOT be quiet!
April 2, 2025 at 1:16 AM
Real roller coaster day for US scientists. A powerful stand from Cory Booker while NIH and CDC were simultaneously being gutted.
We will NOT be quiet!
We will NOT be quiet!
And finally, we confirmed that this pathway is actually occurring in vivo! When we fasted mice to induce ketogenesis, treating them with HDAC inhibitors prevented Kbhb formation in some organs!
March 26, 2025 at 2:02 PM
And finally, we confirmed that this pathway is actually occurring in vivo! When we fasted mice to induce ketogenesis, treating them with HDAC inhibitors prevented Kbhb formation in some organs!
We developed an in vitro reconstitution assay to establish that yes, HDACs can catalyze the covalent attachment of BHB to lysine and this requires the classical active site normally used for deacetylation
March 26, 2025 at 2:02 PM
We developed an in vitro reconstitution assay to establish that yes, HDACs can catalyze the covalent attachment of BHB to lysine and this requires the classical active site normally used for deacetylation
We figured out that blocking HDACs prevented lysine modification by BHB. This was the opposite of what we expected! This is also when we looped in @gburslem.bsky.social because I told him "uhh, I think HDACs are doing something weird"
March 26, 2025 at 2:02 PM
We figured out that blocking HDACs prevented lysine modification by BHB. This was the opposite of what we expected! This is also when we looped in @gburslem.bsky.social because I told him "uhh, I think HDACs are doing something weird"
Moreover, genetic and pharmacological approaches both showed that inhibiting p300/CBP has no influence on Kbhb formation in BHB-treated cells
March 26, 2025 at 2:02 PM
Moreover, genetic and pharmacological approaches both showed that inhibiting p300/CBP has no influence on Kbhb formation in BHB-treated cells
The model for Kbhb formation is through a BHB-CoA/p300-dependent mechanism, but the BHB-CoA synthetase is unknown. We had data that butyrate blocked Kbhb formation and designed a metabolomics experiment to figure out how. But BHB-CoA did not match Kbhb. This is when we re-imagined alt mechanisms
March 26, 2025 at 2:02 PM
The model for Kbhb formation is through a BHB-CoA/p300-dependent mechanism, but the BHB-CoA synthetase is unknown. We had data that butyrate blocked Kbhb formation and designed a metabolomics experiment to figure out how. But BHB-CoA did not match Kbhb. This is when we re-imagined alt mechanisms
Commuting by ferry has many perks
March 25, 2025 at 2:15 AM
Commuting by ferry has many perks
I found my 2017 March for Science photo. My message is sadly more pressing. But I'm pumped to keep showing up and to keep fighting
February 28, 2025 at 4:54 AM
I found my 2017 March for Science photo. My message is sadly more pressing. But I'm pumped to keep showing up and to keep fighting
I am starting this morning by reaching outside of my science echo chamber (posting on facebook) to explain why the NIH matters and why the new indirect rate policy will be catastrophic to everyone
February 8, 2025 at 7:00 PM
I am starting this morning by reaching outside of my science echo chamber (posting on facebook) to explain why the NIH matters and why the new indirect rate policy will be catastrophic to everyone
The autonomous car can't figure out that the bus is parked to go around and take their right turn at the green light. A regular sight on SF 😅
February 6, 2025 at 5:54 PM
The autonomous car can't figure out that the bus is parked to go around and take their right turn at the green light. A regular sight on SF 😅