David Pla Martin
@dplamartin.bsky.social
Professor @hhu_de Mitochondrial Biology 🧬 | Institute of Biochemistry and Molecular Biology I | mitochondria, mtDNA and mitophagy http://bit.ly/bumb1
Pinned
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by David Pla Martin
🦆 Junge Stud-Ente genießt das Nachtleben auf dem Campus.
Danke @mel_nrv für das Foto! 🥰
^lm
Danke @mel_nrv für das Foto! 🥰
^lm
November 10, 2025 at 4:13 PM
🦆 Junge Stud-Ente genießt das Nachtleben auf dem Campus.
Danke @mel_nrv für das Foto! 🥰
^lm
Danke @mel_nrv für das Foto! 🥰
^lm
Reposted by David Pla Martin
🌟 Exciting news! Dr. David Pla Martin is joining our Cell & Molecular Biology section as an editorial board member. @dplamartin.bsky.social's work in mitochondrial function, mtDNA, mitochondrial quality, and selective mitophagy will be a fantastic addition. Welcome! 🧬🔋🧫
October 23, 2025 at 9:20 PM
🌟 Exciting news! Dr. David Pla Martin is joining our Cell & Molecular Biology section as an editorial board member. @dplamartin.bsky.social's work in mitochondrial function, mtDNA, mitochondrial quality, and selective mitophagy will be a fantastic addition. Welcome! 🧬🔋🧫
Reposted by David Pla Martin
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
October 14, 2025 at 11:50 AM
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
Reposted by David Pla Martin
Protein complex, the retromer, promotes recycling/disposal of damaged mitochondrial DNA
📷 Parisa Kakanj & Mari Bonse et al
@dplamartin.bsky.social
lab University of Cologne, Cologne, Germany in
@science.org Science Advances
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
📷 Parisa Kakanj & Mari Bonse et al
@dplamartin.bsky.social
lab University of Cologne, Cologne, Germany in
@science.org Science Advances
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
May 8, 2025 at 10:57 AM
Protein complex, the retromer, promotes recycling/disposal of damaged mitochondrial DNA
📷 Parisa Kakanj & Mari Bonse et al
@dplamartin.bsky.social
lab University of Cologne, Cologne, Germany in
@science.org Science Advances
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
📷 Parisa Kakanj & Mari Bonse et al
@dplamartin.bsky.social
lab University of Cologne, Cologne, Germany in
@science.org Science Advances
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
Reposted by David Pla Martin
Small molecules restore mutant mitochondrial DNA polymerase activity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
www.nature.com
April 9, 2025 at 4:51 PM
Small molecules restore mutant mitochondrial DNA polymerase activity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Pla Martin
What a lovely paper from @dplamartin.bsky.social and his team! Mechanistic insight to mtDNA turnover at the lysosomes. 📬
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
April 5, 2025 at 7:16 AM
What a lovely paper from @dplamartin.bsky.social and his team! Mechanistic insight to mtDNA turnover at the lysosomes. 📬
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
April 4, 2025 at 6:42 PM
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Are u tired of reading about tariffs? Then take a look to our last work! @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
April 4, 2025 at 6:07 PM
Are u tired of reading about tariffs? Then take a look to our last work! @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Tomorrow will be a good day! I can’t wait to show you what we have…
April 3, 2025 at 12:09 PM
Tomorrow will be a good day! I can’t wait to show you what we have…
A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A
www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/8/6/...
The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation
Pathogenic variants in the mitochondrial protein MFN2 are typically associated with a peripheral neuropathy phenotype, but can also cause a variety of additional pathologies including myopathy. Here, ...
www.life-science-alliance.org
April 3, 2025 at 6:46 AM
A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A
www.life-science-alliance.org/content/8/6/...
www.life-science-alliance.org/content/8/6/...
Being a PI is hard, we have to deal with one rejection after another, hours of work amounting to nothing because someone thinks our ideas aren’t cool enough. But then, suddenly, you get a yes! And life shines again. Thanks, @dfg.de , for your support!
April 3, 2025 at 5:58 AM
Being a PI is hard, we have to deal with one rejection after another, hours of work amounting to nothing because someone thinks our ideas aren’t cool enough. But then, suddenly, you get a yes! And life shines again. Thanks, @dfg.de , for your support!
Reposted by David Pla Martin
I'm super happy that our story is now published!
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
March 21, 2025 at 2:09 PM
I'm super happy that our story is now published!
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
Reposted by David Pla Martin
Whoa - are a significant proportion of sporadic ALS/motor neuron disease cases a mitochondrial DNA disease?! #mitochondria
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis - Nature Neuroscience
Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in mitochondrial CIV induce...
www.nature.com
March 15, 2025 at 11:11 AM
Whoa - are a significant proportion of sporadic ALS/motor neuron disease cases a mitochondrial DNA disease?! #mitochondria
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Pla Martin
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
openrxiv.org
March 11, 2025 at 1:20 PM
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Great job! Many have tried, many have failed.
Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Combined expression of a mitochondrially targeted endonuclease and end-joining machinery
enables formation of mtDNA deletions with a broad range of heteroplasmy.
www.cell.com
March 10, 2025 at 3:51 PM
Great job! Many have tried, many have failed.
Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Combined expression of a mitochondrially targeted endonuclease and end-joining machinery
enables formation of mtDNA deletions with a broad range of heteroplasmy.
www.cell.com
March 10, 2025 at 3:48 PM
Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...
Reposted by David Pla Martin
Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Combined expression of a mitochondrially targeted endonuclease and end-joining machinery
enables formation of mtDNA deletions with a broad range of heteroplasmy.
www.cell.com
March 10, 2025 at 3:05 PM
Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...
Reposted by David Pla Martin
mtDNA goes places, and sometimes nucleoids end up in stressful situations. Our next speaker @lauraenewmanphd.bsky.social
is keeping an eye (or two) on this, and will tell us all about it.
This week, usual time and place.
is keeping an eye (or two) on this, and will tell us all about it.
This week, usual time and place.
March 3, 2025 at 4:45 PM
mtDNA goes places, and sometimes nucleoids end up in stressful situations. Our next speaker @lauraenewmanphd.bsky.social
is keeping an eye (or two) on this, and will tell us all about it.
This week, usual time and place.
is keeping an eye (or two) on this, and will tell us all about it.
This week, usual time and place.
Reposted by David Pla Martin
Today is Rare disease day!
There are over 6000 rare diseases that present with a variety of symptoms affecting all organs. Although we call them rare, they affect over 300 millions of individuals world-wide. Help raise awareness, so we, scientists, can search for cures.
There are over 6000 rare diseases that present with a variety of symptoms affecting all organs. Although we call them rare, they affect over 300 millions of individuals world-wide. Help raise awareness, so we, scientists, can search for cures.
February 28, 2025 at 5:15 PM
Today is Rare disease day!
There are over 6000 rare diseases that present with a variety of symptoms affecting all organs. Although we call them rare, they affect over 300 millions of individuals world-wide. Help raise awareness, so we, scientists, can search for cures.
There are over 6000 rare diseases that present with a variety of symptoms affecting all organs. Although we call them rare, they affect over 300 millions of individuals world-wide. Help raise awareness, so we, scientists, can search for cures.
That looks like something I must read
Are you curious about how motile our mitochondrial genomes are 🧬? Live-cell nucleoid data inspired us to discuss exciting ideas from the field with amazing @isimolinar.bsky.social and Verónica Eisner in our new opinion at TCB 🤩! Here is a free-access link authors.elsevier.com/c/1keJq3QxxS....
February 21, 2025 at 4:00 PM
That looks like something I must read
Reposted by David Pla Martin
Are you curious about how motile our mitochondrial genomes are 🧬? Live-cell nucleoid data inspired us to discuss exciting ideas from the field with amazing @isimolinar.bsky.social and Verónica Eisner in our new opinion at TCB 🤩! Here is a free-access link authors.elsevier.com/c/1keJq3QxxS....
February 21, 2025 at 3:54 PM
Are you curious about how motile our mitochondrial genomes are 🧬? Live-cell nucleoid data inspired us to discuss exciting ideas from the field with amazing @isimolinar.bsky.social and Verónica Eisner in our new opinion at TCB 🤩! Here is a free-access link authors.elsevier.com/c/1keJq3QxxS....
Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1 - Nature
We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, ...
www.nature.com
February 20, 2025 at 9:17 AM
Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Pla Martin
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
Organelle network is regulated to prevent cellular inflammation.
www.nature.com
February 20, 2025 at 9:14 AM
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
Organelle network is regulated to prevent cellular inflammation.
www.nature.com
February 20, 2025 at 9:14 AM
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
www.nature.com/articles/d41...
www.nature.com/articles/d41...