Congratulations!!!!!🎉🍾🎊

This work was led by the amazing former postdoc Ken Louie, and an all star research team and collaborators to make it happen! #aDBS #Parkinsons #gait

We tested the effects of adaptive DBS both in clinic and at home and found that aDBS improves gait symmetry and variability in patients with Parkinson’s disease! Providing an exciting and promising therapy to restore gait functions.

Here, we use chronically implanted bidirectional DBS devices connected to pallidal leads and cortical ECoG strips to 1) capture biomarkers of leg swing during natural walking 2) use these biomarkers to rapidly change stimulation amplitudes during each gait cycle in an embedded device.

Very much looking forward to our speakers: @maryamshanechi.bsky.social, @hugospiers.bsky.social, Marom Bikson, @jenpitt.bsky.social, Mary Czerwinski, @peabody124.bsky.social, @dpferris.bsky.social, @sladouce.bsky.social, Matthew Rizzo,
@c-rothkopf.bsky.social, @doriswang.bsky.social, Ying Choon Wu

It suggests that abnormal pallidal outflow and synchronization between the pallidum and motor cortices may be a pathophysiological mechanism underlying disordered postural response in Parkinson's disease.

Our results provide evidence for a model where synchronized premotor and motor cortical activities transiently couple with the globus pallidus to regulate the timing of postural responses, and local pallidal activity regulate the amplitude of postural changes during gait initiation.

We found distinct patterns of oscillatory changes that occur in the pallidum and motor cortex, and found that while pallidum gamma power is predictive of the scaling of gait initiation, pallidal M1, and premotor-M1 low frequency coherence is predictive of the timing of weight shift