Unicore is fast, accurate, and universal. Unicore reconstructed consistent phylogeny of bacterial/fungal species, while maintaining linear time scale over the input size. Besides, Unicore works with any given taxa, presenting scalable and universal method for structure-based phylogeny. 🧵3/n

With Unicore, we identified 13 structural core genes from 166 species across the Tree of Life, where 8 of them could only be defined using structures. Projected on the Tree of Life reconstructed with Unicore, you can see the universally conserved structure of one of the structural core genes. 🧵2/n

Unicore is now published on GBE 🚀
Unicore rapidly identifies structural single-copy core genes from input species proteomes for phylogenetic analysis. Powered by Foldseek and ProstT5, Unicore enables linear-scale structure-based phylogeny of any given set of taxa. 🧵1/n
📃 doi.org/10.1093/gbe/evaf109