Dolf Weijers
@dolfweijers.bsky.social
Chair of Biochemistry @wur, interested in the biochemical basis of multicellular development and auxin response, and science in general; Views are my own
https://shorturl.at/U80ZH
https://shorturl.at/U80ZH
That’s only the beginning 😃
November 7, 2025 at 5:41 AM
That’s only the beginning 😃
This work was primarily led by Joris Sprakel, and it was a pleasure to see this develop! Feeback is appreciated! Please note the cool microfluidic protein-DNA single molecule assay 😃
November 7, 2025 at 5:39 AM
This work was primarily led by Joris Sprakel, and it was a pleasure to see this develop! Feeback is appreciated! Please note the cool microfluidic protein-DNA single molecule assay 😃
We believe this work offers an explanation to why ARFs have the capacity to condensate. An open question is whether this is a general ARF property, and if it is shared with other, condensate-forming ARFs (Strader lab). 5/x
November 7, 2025 at 5:39 AM
We believe this work offers an explanation to why ARFs have the capacity to condensate. An open question is whether this is a general ARF property, and if it is shared with other, condensate-forming ARFs (Strader lab). 5/x
Instead, what likely forms in vivo are small clusters. Using bulk and single molecule protein-DNA binding assays, Kasper shows that these nanoclusters combine high affinity AND high specificity 4/x
November 7, 2025 at 5:39 AM
Instead, what likely forms in vivo are small clusters. Using bulk and single molecule protein-DNA binding assays, Kasper shows that these nanoclusters combine high affinity AND high specificity 4/x
Kasper and Bas used Marchantia ARF2 as a model to study assemblies in vivo, and behavior in vitro. ARF2 can form large condensates, but concentrations in nuclei are well below the concentration needed for this 3/x
November 7, 2025 at 5:39 AM
Kasper and Bas used Marchantia ARF2 as a model to study assemblies in vivo, and behavior in vitro. ARF2 can form large condensates, but concentrations in nuclei are well below the concentration needed for this 3/x
Like other TF’s, ARFs can form condensates, but what assemblies naturally form and how condensation contributes to function was unclear 2/x
November 7, 2025 at 5:39 AM
Like other TF’s, ARFs can form condensates, but what assemblies naturally form and how condensation contributes to function was unclear 2/x
Happy to see this work out! Kasper Arfman (yes, his real name) and Bas Janssen identify ARF nanoclusters as the likely functional unit in binding DNA 1/x
November 7, 2025 at 5:39 AM
Happy to see this work out! Kasper Arfman (yes, his real name) and Bas Janssen identify ARF nanoclusters as the likely functional unit in binding DNA 1/x
You ensured with thisl paper that hopes are high 😉
October 31, 2025 at 6:21 PM
You ensured with thisl paper that hopes are high 😉
Fantastic, Omaya, Gautam, Felix and colleagues. Magnificent and awe-inspiring work 🤩
October 31, 2025 at 3:19 PM
Fantastic, Omaya, Gautam, Felix and colleagues. Magnificent and awe-inspiring work 🤩
Was nice to meet and work together!
October 29, 2025 at 9:50 PM
Was nice to meet and work together!
Still listen to it regularly, eepecially on vinyl 🤩
October 29, 2025 at 5:21 PM
Still listen to it regularly, eepecially on vinyl 🤩
October 29, 2025 at 4:41 PM
October 29, 2025 at 4:40 PM
With shared bases between opposing strands…? What an invention!
October 26, 2025 at 1:00 PM
With shared bases between opposing strands…? What an invention!
We are all very proud of you, Andre. And to those seeking a PhD project: Run! Andre is a wonderful scientist and mentor and does cool science!!!
October 23, 2025 at 4:39 PM
We are all very proud of you, Andre. And to those seeking a PhD project: Run! Andre is a wonderful scientist and mentor and does cool science!!!
Will do! It is refreshing. Drinks on me next time we meet
October 21, 2025 at 5:06 PM
Will do! It is refreshing. Drinks on me next time we meet
It’s fantastic, Oded!
October 21, 2025 at 4:58 PM
It’s fantastic, Oded!
Mooi interview, Floor!
October 17, 2025 at 4:55 AM
Mooi interview, Floor!
This field would have looked very differently without your pioneering efforts, Liz!
October 7, 2025 at 5:50 PM
This field would have looked very differently without your pioneering efforts, Liz!
Congrats David!!! Sounds like such an exciting move! Happy science!
October 1, 2025 at 5:38 AM
Congrats David!!! Sounds like such an exciting move! Happy science!
Damn…one day this will be a monument
September 29, 2025 at 7:44 PM
Damn…one day this will be a monument
That is an explanation, not an excuse
September 23, 2025 at 1:53 PM
That is an explanation, not an excuse
Happy birthday!!!
September 17, 2025 at 8:56 PM
Happy birthday!!!