Joerg Doellinger
@doellingerj.bsky.social
#Proteomics researcher fighting infectious disease @RKI (German Public Health Institute). Thoughts are my own. #TeamMassSpec
Sounds amazing. I will most likely be a heavy InfinDIA user in the future!
September 26, 2025 at 10:41 AM
Sounds amazing. I will most likely be a heavy InfinDIA user in the future!
vPro-MS identifies viruses in DIA data with > 99,99% specificity without affecting sensitivity from a database built from > 20,000 genomes. Throughput, quantitation and specificity are already on pair with genomics and sensitivity will most likely increase in the future.
August 5, 2025 at 2:14 PM
vPro-MS identifies viruses in DIA data with > 99,99% specificity without affecting sensitivity from a database built from > 20,000 genomes. Throughput, quantitation and specificity are already on pair with genomics and sensitivity will most likely increase in the future.
I was told this does not work because the Opentron Flex is not able to push the liquid stack through the Evotip. It can not push hard enough on the tips. If you should receive a protocol, I would really like to know if it works.
June 17, 2025 at 7:48 PM
I was told this does not work because the Opentron Flex is not able to push the liquid stack through the Evotip. It can not push hard enough on the tips. If you should receive a protocol, I would really like to know if it works.
Obviously we report IDs with a certain error in proteomics. I do infectious disease diagnostics with DIA and so correct IDs matter most to me. I don't look at peaks but adjust/develop post processing tools when I need 100% specificity (which is possible),see fig3 here www.medrxiv.org/content/10.1...
December 9, 2024 at 7:23 PM
Obviously we report IDs with a certain error in proteomics. I do infectious disease diagnostics with DIA and so correct IDs matter most to me. I don't look at peaks but adjust/develop post processing tools when I need 100% specificity (which is possible),see fig3 here www.medrxiv.org/content/10.1...
After all samples are measured you can trigger such a combined analysis in Proteoscape based on the "real-time" results. It's still much faster than offline search and results for SN19 are quite identical (< 1% PrecursorIds). Plus no need for data transfer.
November 30, 2024 at 10:02 AM
After all samples are measured you can trigger such a combined analysis in Proteoscape based on the "real-time" results. It's still much faster than offline search and results for SN19 are quite identical (< 1% PrecursorIds). Plus no need for data transfer.
Spectronaut 19 is currently implemented in Proteoscape. It's not a real time analysis, depending on the gradient length, Spectronaut lags 1 or 2 samples behind data aquisition. After running a sequence, multiple samples can be combined in a "second" search. It's convenient. We use it a lot.
November 30, 2024 at 9:16 AM
Spectronaut 19 is currently implemented in Proteoscape. It's not a real time analysis, depending on the gradient length, Spectronaut lags 1 or 2 samples behind data aquisition. After running a sequence, multiple samples can be combined in a "second" search. It's convenient. We use it a lot.