Dina Schneidman
@dinaschneidman.bsky.social
Computational Structural Biology, The Hebrew University of Jerusalem
1/ Missense variant effect predictors (VEPs) are very accurate but are they trustworthy?
Not if their probability outputs aren’t calibrated.
Our new method, RaCoon, fixes this by calibrating VEPs at the residue level, where miscalibration actually happens. www.biorxiv.org/content/10.1...
Not if their probability outputs aren’t calibrated.
Our new method, RaCoon, fixes this by calibrating VEPs at the residue level, where miscalibration actually happens. www.biorxiv.org/content/10.1...
Calibrated Variant Effect Prediction at the Residue Level Using Conditional Score Distributions
Effective clinical use of variant effect prediction (VEP) requires models that are both accurate and well-calibrated. Calibration refers to a model’s ability to produce meaningful and reliable probabi...
www.biorxiv.org
December 1, 2025 at 10:35 AM
1/ Missense variant effect predictors (VEPs) are very accurate but are they trustworthy?
Not if their probability outputs aren’t calibrated.
Our new method, RaCoon, fixes this by calibrating VEPs at the residue level, where miscalibration actually happens. www.biorxiv.org/content/10.1...
Not if their probability outputs aren’t calibrated.
Our new method, RaCoon, fixes this by calibrating VEPs at the residue level, where miscalibration actually happens. www.biorxiv.org/content/10.1...
Reposted by Dina Schneidman
Still time to register for the next CAPRI round and put your methods to the test for predicting the structure of four antibody-antigen complexes - prediction period opening on Sept. 29th.
Announcing CAPRI round 61 with four antibody-antigen targets - registration is open and the prediction period starts on Monday September 29th. Put your methods to the test! Visit… | Alexandre Bonvin
Announcing CAPRI round 61 with four antibody-antigen targets - registration is open and the prediction period starts on Monday September 29th. Put your methods to the test! Visit https://lnkd.in/ei68T...
www.linkedin.com
September 24, 2025 at 1:30 PM
Still time to register for the next CAPRI round and put your methods to the test for predicting the structure of four antibody-antigen complexes - prediction period opening on Sept. 29th.
Reposted by Dina Schneidman
The second annual ALADDIN project meeting has come to an end! 👏
We thank our hosts from @liu.se for a well-organised meeting and our project partners for their presentations & insightful conversations.
As we approach our halfway milestone, things will only speed up!
#EICPathfinder
We thank our hosts from @liu.se for a well-organised meeting and our project partners for their presentations & insightful conversations.
As we approach our halfway milestone, things will only speed up!
#EICPathfinder
September 4, 2025 at 12:37 PM
The second annual ALADDIN project meeting has come to an end! 👏
We thank our hosts from @liu.se for a well-organised meeting and our project partners for their presentations & insightful conversations.
As we approach our halfway milestone, things will only speed up!
#EICPathfinder
We thank our hosts from @liu.se for a well-organised meeting and our project partners for their presentations & insightful conversations.
As we approach our halfway milestone, things will only speed up!
#EICPathfinder
Reposted by Dina Schneidman
Unfortunately it’s clear that the Israeli people can’t topple the government or change its ways. Seems like the attorney general, the last gate keeper, will be fired soon. As long as we’re stuck with this government, the war won’t stop. Only international intervention (=the U.S) might do it.
August 3, 2025 at 10:11 AM
Unfortunately it’s clear that the Israeli people can’t topple the government or change its ways. Seems like the attorney general, the last gate keeper, will be fired soon. As long as we’re stuck with this government, the war won’t stop. Only international intervention (=the U.S) might do it.
Reposted by Dina Schneidman
A small reminder to all structural biologists around working on biomolecular complexes: please consider sharing your complexes as targets for CAPRI - AI has not solved all structure prediction problems and there are still challenges! See www.capri-docking.org/contribute/
CAPRI Docking
www.capri-docking.org
July 29, 2025 at 6:26 AM
A small reminder to all structural biologists around working on biomolecular complexes: please consider sharing your complexes as targets for CAPRI - AI has not solved all structure prediction problems and there are still challenges! See www.capri-docking.org/contribute/
Reposted by Dina Schneidman
The first comprehensive atlas of allele-specific DNA methylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Atlas of imprinted and allele-specific DNA methylation in the human body - Nature Communications
DNA methylation drives parental expression differences at imprinted genes. Here, the authors uncover hundreds of ubiquitous and tissue-specific differentially methylated regions, offering insights int...
www.nature.com
March 11, 2025 at 2:20 PM
The first comprehensive atlas of allele-specific DNA methylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...