Dianne
@dianvanderwaldr.bsky.social
Cell biologist #platelets #glycans #HemSky #ExtracellularVesicles 👩🔬#research #transfusion #mentoring 📢#SciComm 📸#photography 🦜#birds 🐈#redcats 🎛#music 🇾🇪#Dutch
🇦🇺#Australia
➡️Diannevanderwal.com
🇦🇺#Australia
➡️Diannevanderwal.com
Pinned
Dianne
@dianvanderwaldr.bsky.social
· Mar 25
We have worked for 2 years with @dianvanderwaldr.bsky.social to propose a protocol for platelet desialylation, and we are excited to now share it. Communication from the ISTH SSC Platelet Physiology. - Journal of Thrombosis and Haemostasis www.jthjournal.org/article/S153... #hemsky #hemesky
Consensus protocol for platelet desialylation (β-galactose exposure) quantification using lectins by flow cytometry: Communication from the ISTH SSC Subcommittee on Platelet Physiology.
Platelets contain many heterogeneous carbohydrates (glycans): often capped by sialic
acid. The removal of sialic acid (desialylation) is important for platelet function
and clearance, leading to novel...
www.jthjournal.org
Reposted by Dianne
#Medsky🧪 #IDSky #immunosky #publichealth Studies have shown that elderly individuals who have recovered from #COVID have a significantly higher and longer-lasting rate of #apoptosis (programmed cell death) in their #peripheralbloodmononuclearcells (PBMCs) vs to age-matched controls.
November 6, 2025 at 5:12 AM
#Medsky🧪 #IDSky #immunosky #publichealth Studies have shown that elderly individuals who have recovered from #COVID have a significantly higher and longer-lasting rate of #apoptosis (programmed cell death) in their #peripheralbloodmononuclearcells (PBMCs) vs to age-matched controls.
Daily small portion almonds and 🍫 lowers heart attack risk 🧪
Effects of Dark Chocolate and Almonds on Cardiovascular Risk Factors in Overweight and Obese Individuals: A Randomized Controlled‐Feeding Trial | Journal of the American Heart Association www.ahajournals.org/doi/full/10....
Effects of Dark Chocolate and Almonds on Cardiovascular Risk Factors in Overweight and Obese Individuals: A Randomized Controlled‐Feeding Trial | Journal of the American Heart Association
BackgroundConsumption of almonds or dark chocolate and cocoa has favorable effects on markers
of coronary heart disease; however, the combined effects have not been evaluated in
a well‐controlled feed...
www.ahajournals.org
November 1, 2025 at 10:18 AM
Daily small portion almonds and 🍫 lowers heart attack risk 🧪
Last days of Italian food...
October 5, 2025 at 4:37 PM
Last days of Italian food...
So inspiring to have watched her in Sydney years ago, one of THE nature trailblazers of our time & 1st #womeninSTEM It's a sad day but her legacy will 4ever continue Dr. Goodall 🦸♀️👩🔬
October 1, 2025 at 7:52 PM
So inspiring to have watched her in Sydney years ago, one of THE nature trailblazers of our time & 1st #womeninSTEM It's a sad day but her legacy will 4ever continue Dr. Goodall 🦸♀️👩🔬
Reposted by Dianne
PSA:
Your period should not
🩸last > 7 days
🩸interfere with your life
🩸happen consistently > than monthly
🩸require product changes more than every 2 hours
🩸have clots larger than a quarter
🩸cause debilitating pain
🩸require double product coverage
🩸make you anemic
Your period should not
🩸last > 7 days
🩸interfere with your life
🩸happen consistently > than monthly
🩸require product changes more than every 2 hours
🩸have clots larger than a quarter
🩸cause debilitating pain
🩸require double product coverage
🩸make you anemic
September 20, 2025 at 7:21 PM
PSA:
Your period should not
🩸last > 7 days
🩸interfere with your life
🩸happen consistently > than monthly
🩸require product changes more than every 2 hours
🩸have clots larger than a quarter
🩸cause debilitating pain
🩸require double product coverage
🩸make you anemic
Your period should not
🩸last > 7 days
🩸interfere with your life
🩸happen consistently > than monthly
🩸require product changes more than every 2 hours
🩸have clots larger than a quarter
🩸cause debilitating pain
🩸require double product coverage
🩸make you anemic
Reposted by Dianne
"Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis" www.thelancet.com/journals/lan...
Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis
These findings add to the evidence that clopidogrel monotherapy is superior to aspirin
monotherapy for MACCE prevention with no increase in the risk of bleeding, and support
the preferential use of cl...
www.thelancet.com
September 8, 2025 at 3:18 PM
"Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis" www.thelancet.com/journals/lan...
Reposted by Dianne
"Impact of Race on Profiles of Platelet Reactivity and Clinical Outcomes in Clopidogrel-Treated Participants"
ascpt.onlinelibrary.wiley.com/doi/abs/10.1...
ascpt.onlinelibrary.wiley.com/doi/abs/10.1...
Impact of Race on Profiles of Platelet Reactivity and Clinical Outcomes in Clopidogrel‐Treated Participants
Black individuals undergoing percutaneous coronary intervention (PCI) experience higher rates of major adverse cardiovascular events (MACE) than non-Black individuals. This study assessed the racial ...
ascpt.onlinelibrary.wiley.com
September 8, 2025 at 3:24 PM
"Impact of Race on Profiles of Platelet Reactivity and Clinical Outcomes in Clopidogrel-Treated Participants"
ascpt.onlinelibrary.wiley.com/doi/abs/10.1...
ascpt.onlinelibrary.wiley.com/doi/abs/10.1...
'Home' sweet Home, a few phone snaps. Looking forward to taking my Nikon camera for a spin 😊
September 8, 2025 at 8:21 AM
'Home' sweet Home, a few phone snaps. Looking forward to taking my Nikon camera for a spin 😊
Reposted by Dianne
MORE SCIENCE TALK ON BLUESKY:
"During August, there were twice as many posts about science 🧪 each day compared with July and more than triple the number from March"
www.theguardian.com/technology/2...
Related, growing Bluesky chatter about this study www.nature.com/articles/s41...
"During August, there were twice as many posts about science 🧪 each day compared with July and more than triple the number from March"
www.theguardian.com/technology/2...
Related, growing Bluesky chatter about this study www.nature.com/articles/s41...
September 3, 2025 at 1:57 AM
MORE SCIENCE TALK ON BLUESKY:
"During August, there were twice as many posts about science 🧪 each day compared with July and more than triple the number from March"
www.theguardian.com/technology/2...
Related, growing Bluesky chatter about this study www.nature.com/articles/s41...
"During August, there were twice as many posts about science 🧪 each day compared with July and more than triple the number from March"
www.theguardian.com/technology/2...
Related, growing Bluesky chatter about this study www.nature.com/articles/s41...
Reposted by Dianne
The #ISTH2025 recorded sessions are now available via the ISTH Academy.
@ISTH.org members can view the content freely and non-members can purchase access separately on the ISTH Academy.
Learn more: isthcongress.org/on-demand
Note: Some presenters did not allow their presentations to be archived.
@ISTH.org members can view the content freely and non-members can purchase access separately on the ISTH Academy.
Learn more: isthcongress.org/on-demand
Note: Some presenters did not allow their presentations to be archived.
August 14, 2025 at 2:30 PM
The #ISTH2025 recorded sessions are now available via the ISTH Academy.
@ISTH.org members can view the content freely and non-members can purchase access separately on the ISTH Academy.
Learn more: isthcongress.org/on-demand
Note: Some presenters did not allow their presentations to be archived.
@ISTH.org members can view the content freely and non-members can purchase access separately on the ISTH Academy.
Learn more: isthcongress.org/on-demand
Note: Some presenters did not allow their presentations to be archived.
Reposted by Dianne
⏳Early career researchers: Time is running out to apply for the ISTH Claire McLintock Award! This award offers $20,000 USD to support groundbreaking research in women’s health and thrombosis or hemostasis.
Apply today: www.isth.org/page/McLintockAward
Apply today: www.isth.org/page/McLintockAward
August 21, 2025 at 3:44 PM
⏳Early career researchers: Time is running out to apply for the ISTH Claire McLintock Award! This award offers $20,000 USD to support groundbreaking research in women’s health and thrombosis or hemostasis.
Apply today: www.isth.org/page/McLintockAward
Apply today: www.isth.org/page/McLintockAward
Reposted by Dianne
I wrote an op-ed on the world-class STEM research ecosystem in the United States, and how this ecosystem is now under attack on multiple fronts by the current administration: newsletter.ofthebrave.org/p/im-an-awar...
I’m an award-winning mathematician. Trump just cut my funding.
The “Mozart of Math” tried to stay out of politics. Then it came for his research.
newsletter.ofthebrave.org
August 18, 2025 at 3:45 PM
I wrote an op-ed on the world-class STEM research ecosystem in the United States, and how this ecosystem is now under attack on multiple fronts by the current administration: newsletter.ofthebrave.org/p/im-an-awar...
Reposted by Dianne
This year the ASH Bridge Grant is funding 25 scientists with $3.75M, 5X more than last year, to keep hematology research moving forward. Congratulations to the recipients! https://bit.ly/3HJ51Ma
#HemeSky #MedSKy #ASHAwards
#HemeSky #MedSKy #ASHAwards
August 19, 2025 at 4:50 PM
This year the ASH Bridge Grant is funding 25 scientists with $3.75M, 5X more than last year, to keep hematology research moving forward. Congratulations to the recipients! https://bit.ly/3HJ51Ma
#HemeSky #MedSKy #ASHAwards
#HemeSky #MedSKy #ASHAwards
Reposted by Dianne
ADAMTS13's conformational regulation is crucial for enzymatic function & pathophysiology of thrombotic thrombocytopenic purpura. Open ADAMTS13 has emerged as a novel biomarker for acute & subclinical iTTP, aiding in prediction of early relapses during patient follow-up 👉https://bit.ly/40BpoS2
#TTP
#TTP
August 12, 2025 at 9:02 AM
ADAMTS13's conformational regulation is crucial for enzymatic function & pathophysiology of thrombotic thrombocytopenic purpura. Open ADAMTS13 has emerged as a novel biomarker for acute & subclinical iTTP, aiding in prediction of early relapses during patient follow-up 👉https://bit.ly/40BpoS2
#TTP
#TTP
Reposted by Dianne
Thrilled to share our latest work in @natcomms.nature.com !
MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib
MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib
Excited to share that our paper is out in @natcomms.nature.com
🔗 rdcu.be/ez3Gt
We uncover how MICAL1 regulates actin dynamics to enhance VWF–GPIbα binding in platelets.
Big thanks to all co-authors & collaborators !
@hithlabinserm1176.bsky.social @echardlab-pasteur.bsky.social
🔗 rdcu.be/ez3Gt
We uncover how MICAL1 regulates actin dynamics to enhance VWF–GPIbα binding in platelets.
Big thanks to all co-authors & collaborators !
@hithlabinserm1176.bsky.social @echardlab-pasteur.bsky.social
F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets
Nature Communications - To stop bleeding from an injured vessel, platelets adhere and form a clot despite high shear stress from the flow. Here, the authors show that platelet actin disassembly is...
rdcu.be
August 12, 2025 at 10:02 AM
Thrilled to share our latest work in @natcomms.nature.com !
MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib
MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib
Reposted by Dianne
🚨 Reminder! Apply for the ASH Global Research Award for funding, mentorship and global connections.
New: Explorer Pathway supports applicants from lower-income countries with added resources. Apply now: https://bit.ly/4kR2Tkx
#Hematology #ASHAwards #MedSky #HemeSky
New: Explorer Pathway supports applicants from lower-income countries with added resources. Apply now: https://bit.ly/4kR2Tkx
#Hematology #ASHAwards #MedSky #HemeSky
July 24, 2025 at 2:00 PM
🚨 Reminder! Apply for the ASH Global Research Award for funding, mentorship and global connections.
New: Explorer Pathway supports applicants from lower-income countries with added resources. Apply now: https://bit.ly/4kR2Tkx
#Hematology #ASHAwards #MedSky #HemeSky
New: Explorer Pathway supports applicants from lower-income countries with added resources. Apply now: https://bit.ly/4kR2Tkx
#Hematology #ASHAwards #MedSky #HemeSky
Reposted by Dianne
Had a nice little chat about thrombocytosis with some very cool TPO physiology, and a special appearance by Geraldine (back by unpopular demand) wherever you get your podcasts #hemesky #platelets #blood #itsalwaysirondeficiencybutyoucanstillcallus
www.bloodyminded.com.au/allepisodes/...
www.bloodyminded.com.au/allepisodes/...
Episode 53 - PlateLOTS | Approaching Thrombocytosis — Bloody Minded
There’s a problem with billionaires at the moment. Every day, you make a hundred billion platelets. For some in our society, even that colossal quantity isn’t nearly enough. They strive ever onward fo...
www.bloodyminded.com.au
July 16, 2025 at 2:25 AM
Had a nice little chat about thrombocytosis with some very cool TPO physiology, and a special appearance by Geraldine (back by unpopular demand) wherever you get your podcasts #hemesky #platelets #blood #itsalwaysirondeficiencybutyoucanstillcallus
www.bloodyminded.com.au/allepisodes/...
www.bloodyminded.com.au/allepisodes/...
Reposted by Dianne
We’re in this together. Let’s keep hematology moving forward. #Fight4Hematology Donate now. donate.hematology.org/s/
July 16, 2025 at 12:16 AM
We’re in this together. Let’s keep hematology moving forward. #Fight4Hematology Donate now. donate.hematology.org/s/
Reposted by Dianne
🧪🧬🦠🌎🔬🔭🥼👩🔬
NEW: In an unprecedented move, the NIH will soon disinvite dozens of scientists about to take positions on advisory councils that make final decisions on grant funding.
NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.
NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.
Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities
The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.
www.nature.com
July 15, 2025 at 9:59 AM
🧪🧬🦠🌎🔬🔭🥼👩🔬
Reposted by Dianne
While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! See my article in Gen News. www.genengnews.com/topics/trans...
Why We Still Need Animal Research in a World of AI and Organoids
The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.
www.genengnews.com
July 12, 2025 at 2:56 AM
While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! See my article in Gen News. www.genengnews.com/topics/trans...
Reposted by Dianne
💡Last chance to get access to @ISTH.org #ISTH2025 congress content!
You can still obtain virtual access for 30 days, if you register by July 7.
➡️Add on-demand to existing registration: bit.ly/4l7ok07
➡️Purchase on-demand only: bit.ly/3TQBx1n
DON'T MISS IT!
You can still obtain virtual access for 30 days, if you register by July 7.
➡️Add on-demand to existing registration: bit.ly/4l7ok07
➡️Purchase on-demand only: bit.ly/3TQBx1n
DON'T MISS IT!
July 1, 2025 at 2:31 PM
💡Last chance to get access to @ISTH.org #ISTH2025 congress content!
You can still obtain virtual access for 30 days, if you register by July 7.
➡️Add on-demand to existing registration: bit.ly/4l7ok07
➡️Purchase on-demand only: bit.ly/3TQBx1n
DON'T MISS IT!
You can still obtain virtual access for 30 days, if you register by July 7.
➡️Add on-demand to existing registration: bit.ly/4l7ok07
➡️Purchase on-demand only: bit.ly/3TQBx1n
DON'T MISS IT!
Reposted by Dianne
🪶 500 bird species could go extinct within the next 100 years
Researchers warn this shocking statistic risks unravelling ecosystems worldwide.
Only urgent, targeted conservation can prevent mass functional loss.
🔗 www.nature.com/articles/s41...
#ExtinctionCrisis #SciComm 🧪
Researchers warn this shocking statistic risks unravelling ecosystems worldwide.
Only urgent, targeted conservation can prevent mass functional loss.
🔗 www.nature.com/articles/s41...
#ExtinctionCrisis #SciComm 🧪
Threat reduction must be coupled with targeted recovery programmes to conserve global bird diversity - Nature Ecology & Evolution
Projections of extinctions of bird species and losses of functional diversity over the next 100 years suggest that even immediate and widespread threat abatement would be insufficient to prevent losse...
www.nature.com
June 28, 2025 at 4:26 AM
🪶 500 bird species could go extinct within the next 100 years
Researchers warn this shocking statistic risks unravelling ecosystems worldwide.
Only urgent, targeted conservation can prevent mass functional loss.
🔗 www.nature.com/articles/s41...
#ExtinctionCrisis #SciComm 🧪
Researchers warn this shocking statistic risks unravelling ecosystems worldwide.
Only urgent, targeted conservation can prevent mass functional loss.
🔗 www.nature.com/articles/s41...
#ExtinctionCrisis #SciComm 🧪
Reposted by Dianne
Study Shows Decline in Hypertension Awareness Among 🇺🇸 Adults 2013-2023 @jama.com #Cardiology
Concerning ⬆️proportion of adults aged 20 - 44 years who were unaware of having #hypertension, especially females, but no changes among adults aged >45 years.
jamanetwork.com/journals/jam...
Concerning ⬆️proportion of adults aged 20 - 44 years who were unaware of having #hypertension, especially females, but no changes among adults aged >45 years.
jamanetwork.com/journals/jam...
June 28, 2025 at 5:35 AM
Study Shows Decline in Hypertension Awareness Among 🇺🇸 Adults 2013-2023 @jama.com #Cardiology
Concerning ⬆️proportion of adults aged 20 - 44 years who were unaware of having #hypertension, especially females, but no changes among adults aged >45 years.
jamanetwork.com/journals/jam...
Concerning ⬆️proportion of adults aged 20 - 44 years who were unaware of having #hypertension, especially females, but no changes among adults aged >45 years.
jamanetwork.com/journals/jam...