Diana Rubio-Contreras
@diana-rubio.bsky.social
Postdoctoral researcher in @evisoutoglou.bsky.social lab at @gdsc-sussex.bsky.social. Former PhD student in @fgh-lab.bsky.social. DNA repair, genome organisation and genomic instability.
Pinned
Excited to see our research published!! 🎉
Amazing project in @fgh-lab.bsky.social at @ibis-investigacion.bsky.social
"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"
www.nature.com/articles/s41...
Amazing project in @fgh-lab.bsky.social at @ibis-investigacion.bsky.social
"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"
www.nature.com/articles/s41...
Reposted by Diana Rubio-Contreras
🟠 SCIENCE |
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New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis-investigacion.bsky.social @unisevilla.bsky.social
H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death
Cell Death & Disease - H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death
rdcu.be
December 2, 2025 at 9:09 AM
🟠 SCIENCE |
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Reposted by Diana Rubio-Contreras
New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis-investigacion.bsky.social @unisevilla.bsky.social
H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death
Cell Death & Disease - H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death
rdcu.be
December 1, 2025 at 3:17 PM
New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis-investigacion.bsky.social @unisevilla.bsky.social
Excited to see our research published!! 🎉
Amazing project in @fgh-lab.bsky.social at @ibis-investigacion.bsky.social
"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"
www.nature.com/articles/s41...
Amazing project in @fgh-lab.bsky.social at @ibis-investigacion.bsky.social
"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"
www.nature.com/articles/s41...
December 1, 2025 at 10:23 AM
Excited to see our research published!! 🎉
Amazing project in @fgh-lab.bsky.social at @ibis-investigacion.bsky.social
"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"
www.nature.com/articles/s41...
Amazing project in @fgh-lab.bsky.social at @ibis-investigacion.bsky.social
"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"
www.nature.com/articles/s41...
Reposted by Diana Rubio-Contreras
We are excited to welcome Evi Soutoglou and @rubenvanboxtel.bsky.social as our guest speakers at the upcoming GIIN webinar on Tuesday, November 4th at 5 PM Rome / 11 AM NYC.
Join us on zoom: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Join us on zoom: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
October 27, 2025 at 8:15 PM
We are excited to welcome Evi Soutoglou and @rubenvanboxtel.bsky.social as our guest speakers at the upcoming GIIN webinar on Tuesday, November 4th at 5 PM Rome / 11 AM NYC.
Join us on zoom: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Join us on zoom: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Reposted by Diana Rubio-Contreras
Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
A comprehensive genetic catalog of human double-strand break repair
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...
www.science.org
October 4, 2025 at 7:27 AM
Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
Reposted by Diana Rubio-Contreras
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
www.nature.com
September 3, 2025 at 3:59 PM
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
Reposted by Diana Rubio-Contreras
Our latest study is now online! A great collaboration between the @fgh-lab.bsky.social and @enriquedealava.bsky.social Labs, driven by the outstanding work of J. Olmedo-Pelayo at @ibis-investigacion.bsky.social Check it out!
EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism - Oncogene
Oncogene - EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism
www.nature.com
July 29, 2025 at 8:36 AM
Our latest study is now online! A great collaboration between the @fgh-lab.bsky.social and @enriquedealava.bsky.social Labs, driven by the outstanding work of J. Olmedo-Pelayo at @ibis-investigacion.bsky.social Check it out!
Reposted by Diana Rubio-Contreras
New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow.
Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...
www.biorxiv.org
April 28, 2025 at 7:55 AM
New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Diana Rubio-Contreras
Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells
HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.
www.science.org
March 27, 2025 at 10:29 PM
Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...
Reposted by Diana Rubio-Contreras
Suponemos que la publicación en cuestión es esta:
www.nature.com/articles/s41...
¡Enhorabuena @diana-rubio.bsky.social por el premio!
www.nature.com/articles/s41...
¡Enhorabuena @diana-rubio.bsky.social por el premio!
March 5, 2025 at 6:06 PM
Suponemos que la publicación en cuestión es esta:
www.nature.com/articles/s41...
¡Enhorabuena @diana-rubio.bsky.social por el premio!
www.nature.com/articles/s41...
¡Enhorabuena @diana-rubio.bsky.social por el premio!
Reposted by Diana Rubio-Contreras
Su investigación en el #IBiS se ha centrado en la estabilidad del genoma humano a nivel molecular y celular, abarcando desde la comprensión de la respuesta celular a ciertos tipos de quimioterapia hasta las bases moleculares de enfermedades neurodegenerativas
March 4, 2025 at 12:05 PM
Su investigación en el #IBiS se ha centrado en la estabilidad del genoma humano a nivel molecular y celular, abarcando desde la comprensión de la respuesta celular a ciertos tipos de quimioterapia hasta las bases moleculares de enfermedades neurodegenerativas
Reposted by Diana Rubio-Contreras
🔵 La vida con IBiS |
Nuestra enhorabuena a la Dra. Diana Rubio Contreras por ser la ganadora del Premio Nacional de Juventud 2024 en la modalidad de Ciencia y Tecnología y cuya candidatura fue presentada por @FISEVI_sevilla
(Abrimos 🧵) @csic.es @unisevilla.bsky.social
Nuestra enhorabuena a la Dra. Diana Rubio Contreras por ser la ganadora del Premio Nacional de Juventud 2024 en la modalidad de Ciencia y Tecnología y cuya candidatura fue presentada por @FISEVI_sevilla
(Abrimos 🧵) @csic.es @unisevilla.bsky.social
March 4, 2025 at 12:05 PM
🔵 La vida con IBiS |
Nuestra enhorabuena a la Dra. Diana Rubio Contreras por ser la ganadora del Premio Nacional de Juventud 2024 en la modalidad de Ciencia y Tecnología y cuya candidatura fue presentada por @FISEVI_sevilla
(Abrimos 🧵) @csic.es @unisevilla.bsky.social
Nuestra enhorabuena a la Dra. Diana Rubio Contreras por ser la ganadora del Premio Nacional de Juventud 2024 en la modalidad de Ciencia y Tecnología y cuya candidatura fue presentada por @FISEVI_sevilla
(Abrimos 🧵) @csic.es @unisevilla.bsky.social
Reposted by Diana Rubio-Contreras
The Genome Damage and Stability Centre at the University of Sussex has now joined BlueSky! Follow us here, for news, views and publications.
December 6, 2024 at 9:25 AM
The Genome Damage and Stability Centre at the University of Sussex has now joined BlueSky! Follow us here, for news, views and publications.
Reposted by Diana Rubio-Contreras
Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...
Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress - Nature Communications
Transcription creates superhelical stress in DNA, challenging genome stability. Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chr...
www.nature.com
December 5, 2024 at 2:30 PM
Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...