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depmap.org
The Cancer Dependency Map
@depmap.org
100 followers 7 following 5 posts
We construct systematic key datasets and analytical and visualization tools to accelerate precision cancer medicine

Explore the data: https://depmap.org/portal/

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Reposted by The Cancer Dependency Map
vazquezf.bsky.social
(1/3) Excited to share our latest work using
@depmap.org to uncover a new synthetic lethality in two distinct patient populations!

We found that SKI complex inactivation through two independent genomic alterations creates a dependency on PELO

#CancerResearch #SyntheticLethality #Genomics #DepMap
SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature
Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...
nature.com
February 6, 2025 at 1:07 PM
Reposted by The Cancer Dependency Map
depmap.org
Exciting new synthetic lethal target emerging from #depmap data 🧪🧬

Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L

Congratulations to the DepMap team! @vazquezf.bsky.social
#depmap #cancertarget #syntheticlethal
SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature
Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...
www.nature.com
February 5, 2025 at 10:01 PM
depmap.org
Exciting new synthetic lethal target emerging from #depmap data 🧪🧬

Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L

Congratulations to the DepMap team! @vazquezf.bsky.social
#depmap #cancertarget #syntheticlethal
SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature
Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...
www.nature.com
February 5, 2025 at 10:01 PM
depmap.org
Exciting new synthetic lethal target emerging from #depmap data 🧪🧬
Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO
#depmap #cancertarget #syntheticlethal
February 5, 2025 at 9:56 PM
depmap.org
📣Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute)

Highly recommended!

Register here
grc.org/synthetic-le...
2025 Synthetic Lethality Approaches in Oncology Conference GRC
The 2025 Gordon Research Conference on Synthetic Lethality Approaches in Oncology will be held in Portland, Maine. Apply today to reserve your spot.
grc.org
January 29, 2025 at 8:05 PM
depmap.org
DepMap keeps growing—and so does the portal!

To help navigate the portal, new in 24Q4 we’ve launched a new resource page 🚀! Check it out and share your feedback.
Depmap Resources | Depmap Portal
depmap.org
December 20, 2024 at 8:03 AM
depmap.org
We’re kicking off the first DepMap post with a bang!
⭐ 35 CRISPR screens
⭐ NEW data from our Pediatric Dependencies Accelerator Program (learn more at PedDep.org)
⭐ First 281 WES -> WGS
⭐ New Resources page
📣 DepMap is now on dbGaP (phs003444.v1.p1)
Read our release notes for more info!
December 18, 2024 at 7:07 PM