David Posner, PhD
@davidposner.bsky.social
Postdoc @HepworthLab at Manchester Uni; formerly PhD at Cambridge Uni.
Cellular neuroimmunologist 🌈 all things T cells, B cells and Taylor Swift 🇲🇽 🇺🇸 🇬🇧 he/him
Cellular neuroimmunologist 🌈 all things T cells, B cells and Taylor Swift 🇲🇽 🇺🇸 🇬🇧 he/him
Reposted by David Posner, PhD
Listening to the new Taylor Swift album & working on figures, sharing a 🤩 image for #FluorescenceFriday
[penetrating 🐭 cerebral arteriole at the pial surface, aSMA in yellow = smooth muscle cell, pan-laminin in cyan = basement membrane, fibroblast in magenta...squeezing in to cover that vessel 🫂)
[penetrating 🐭 cerebral arteriole at the pial surface, aSMA in yellow = smooth muscle cell, pan-laminin in cyan = basement membrane, fibroblast in magenta...squeezing in to cover that vessel 🫂)
October 3, 2025 at 12:42 PM
Listening to the new Taylor Swift album & working on figures, sharing a 🤩 image for #FluorescenceFriday
[penetrating 🐭 cerebral arteriole at the pial surface, aSMA in yellow = smooth muscle cell, pan-laminin in cyan = basement membrane, fibroblast in magenta...squeezing in to cover that vessel 🫂)
[penetrating 🐭 cerebral arteriole at the pial surface, aSMA in yellow = smooth muscle cell, pan-laminin in cyan = basement membrane, fibroblast in magenta...squeezing in to cover that vessel 🫂)
The outstanding Elizabeth Cooper from @gilbertsonlab.bsky.social just shared a new preprint!! Using cutting-edge tech and models, she found that brain tumours instruct cranial haematopoiesis allowing immunotolerance of childhood brain tumours and CNS development. www.biorxiv.org/content/10.1...
Childhood brain tumours instruct cranial haematopoiesis and immunotolerance
Recent research has revealed a remarkable role for immunosurveillance in healthy and diseased brains, dispelling the notion that this organ is a passive immune-privileged site[1][1]–[3][2]. Better und...
www.biorxiv.org
October 3, 2025 at 1:55 PM
The outstanding Elizabeth Cooper from @gilbertsonlab.bsky.social just shared a new preprint!! Using cutting-edge tech and models, she found that brain tumours instruct cranial haematopoiesis allowing immunotolerance of childhood brain tumours and CNS development. www.biorxiv.org/content/10.1...
Happy to see this published over 10 years after working on it! It was a fun project back in my undergrad days in NY. Using 2D NMR we provide the first direct evidence that fireflies utilise dietary cholesterol to generate lucibufagins, their chemical defense system.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
The Source of Firefly Chemical Defenses: Endogenous Biosynthesis of Lucibufagins from Cholesterol
Fireflies, also known as lightning bugs, are beetles in the family Lampyridae. Several species of North American fireflies have been investigated to determine their toxic components. The primary molec...
pubs.acs.org
September 29, 2025 at 1:04 PM
Happy to see this published over 10 years after working on it! It was a fun project back in my undergrad days in NY. Using 2D NMR we provide the first direct evidence that fireflies utilise dietary cholesterol to generate lucibufagins, their chemical defense system.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by David Posner, PhD
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix):Oxford Road
Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:
www.jobs.manchester.ac.uk
September 12, 2025 at 3:47 PM
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by David Posner, PhD
Science isn’t really moving towards equity; institutions are just perfecting the appearance of equity. We need to build an alternative system, says Dolors Armenteras
go.nature.com/4nzGhp9
go.nature.com/4nzGhp9
Equity in science is a beautiful lie — and I’m done pretending
Science isn’t really moving towards equity; institutions are just perfecting the appearance of equity. We need to build an alternative system.
go.nature.com
September 16, 2025 at 5:01 PM
Science isn’t really moving towards equity; institutions are just perfecting the appearance of equity. We need to build an alternative system, says Dolors Armenteras
go.nature.com/4nzGhp9
go.nature.com/4nzGhp9
New paper alert! 🎉 Check it out here: biorxiv.org/content/10.1... Here we show that intestinal bacterial, helminth and fungal challenges polarise CD4 T cell populations in the dural meninges.
Intestinal challenges shape the polarisation of protective dural memory CD4 T cells
The meninges house several innate and adaptive immune cell populations[1][1]–[3][2]. These predominantly localise within the dura mater and include gut-derived IgA-secreting plasma cells[4][3]. Whethe...
biorxiv.org
September 16, 2025 at 2:43 PM
New paper alert! 🎉 Check it out here: biorxiv.org/content/10.1... Here we show that intestinal bacterial, helminth and fungal challenges polarise CD4 T cell populations in the dural meninges.
Just back from Basel after an inspiring week at the EMBO Tissue Immunity workshop 🧠🫁🧑🦲. I loved giving a flash talk and hearing so many exciting ideas on barrier immunity. Huge thanks to @hepworth-lab.bsky.social for supporting my participation!
September 1, 2025 at 1:35 PM
Just back from Basel after an inspiring week at the EMBO Tissue Immunity workshop 🧠🫁🧑🦲. I loved giving a flash talk and hearing so many exciting ideas on barrier immunity. Huge thanks to @hepworth-lab.bsky.social for supporting my participation!
Reposted by David Posner, PhD
Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough: petition.parliament.uk/petitions/72...
Petition: Review all trade ties with Israel, suspend 2030 roadmap & impose trade sanctions
We call on the Government to review existing trade ties with Israel, suspend the 2030 Roadmap for UK-Israel bilateral relations and impose trade sanctions upon Israel.
petition.parliament.uk
August 5, 2025 at 6:09 PM
Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough: petition.parliament.uk/petitions/72...
Reposted by David Posner, PhD
Spread the news! We are excited to expand our research team, working on cellular senescence, at the Cancer Research UK Cambridge Institute, University of Cambridge.
jobs.cam.ac.uk/job/52026/
jobs.cam.ac.uk/job/52027/
jobs.cam.ac.uk/job/52026/
jobs.cam.ac.uk/job/52027/
a yellow sign that says we 're hiring
ALT: a yellow sign that says we 're hiring
media.tenor.com
July 25, 2025 at 10:06 PM
Spread the news! We are excited to expand our research team, working on cellular senescence, at the Cancer Research UK Cambridge Institute, University of Cambridge.
jobs.cam.ac.uk/job/52026/
jobs.cam.ac.uk/job/52027/
jobs.cam.ac.uk/job/52026/
jobs.cam.ac.uk/job/52027/
Reposted by David Posner, PhD
Fenestrated endothelium enables the extravasation of immune complexes into the synovium. There the interaction of macrophages (producing IL1b, CXCL1) and nociceptive neurons (producing CGRP) induce pain and inflammation.
Hasegawa &al 2024
www.nature.com/articles/s41...
#RheumSky 🧪⑂
Hasegawa &al 2024
www.nature.com/articles/s41...
#RheumSky 🧪⑂
April 29, 2025 at 3:28 PM
Fenestrated endothelium enables the extravasation of immune complexes into the synovium. There the interaction of macrophages (producing IL1b, CXCL1) and nociceptive neurons (producing CGRP) induce pain and inflammation.
Hasegawa &al 2024
www.nature.com/articles/s41...
#RheumSky 🧪⑂
Hasegawa &al 2024
www.nature.com/articles/s41...
#RheumSky 🧪⑂
New paper from Virginia Pedicord's lab just dropped! www.nature.com/articles/s41...
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses - Nature Microbiology
Hexa-acylated lipopolysaccharides from the gut microbiota are associated with efficacy in patients with cancer receiving anti-PD-1 and stimulate host immune activation for enhanced anti-tumour immunit...
www.nature.com
February 11, 2025 at 8:01 AM
New paper from Virginia Pedicord's lab just dropped! www.nature.com/articles/s41...
Reposted by David Posner, PhD
The pre-proof version of our new review is online now at @mucosalimmunol.bsky.social. @lukeocyte.bsky.social and Alanna Kelly (not on Bluesky) deep dive into ILC niches, and discuss how cellular interactions, nutrients and ECM shape our innate immune system!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
There’s no place like home: How local tissue microenvironments shape the function of innate lymphoid cells
Innate lymphoid cells (ILC) have emerged as critical immune effectors with key roles in orchestrating the wider immune response. While ILC are relativ…
www.sciencedirect.com
February 3, 2025 at 2:52 PM
The pre-proof version of our new review is online now at @mucosalimmunol.bsky.social. @lukeocyte.bsky.social and Alanna Kelly (not on Bluesky) deep dive into ILC niches, and discuss how cellular interactions, nutrients and ECM shape our innate immune system!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by David Posner, PhD
A #Science #Immunology Instant Release:
@mmr2.bsky.social, Diane Mathis, & colleagues at @harvard.edu & @institutocajal.bsky.social describe specialized meningeal #Treg subsets that promote #homeostasis of the mouse #brain #meninges & #parenchyma!
@mmr2.bsky.social, Diane Mathis, & colleagues at @harvard.edu & @institutocajal.bsky.social describe specialized meningeal #Treg subsets that promote #homeostasis of the mouse #brain #meninges & #parenchyma!
The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis
Meningeal regulatory T cells restrain local interferon-γ–producing lymphocytes, thereby safeguarding parenchymal brain homeostasis.
www.science.org
January 28, 2025 at 4:05 PM
A #Science #Immunology Instant Release:
@mmr2.bsky.social, Diane Mathis, & colleagues at @harvard.edu & @institutocajal.bsky.social describe specialized meningeal #Treg subsets that promote #homeostasis of the mouse #brain #meninges & #parenchyma!
@mmr2.bsky.social, Diane Mathis, & colleagues at @harvard.edu & @institutocajal.bsky.social describe specialized meningeal #Treg subsets that promote #homeostasis of the mouse #brain #meninges & #parenchyma!
PhDone!!! So happy that I PASSED my viva! Major thx to outstanding examiners @juanquintana.bsky.social and @immunoah.bsky.social for giving me a run for my money 🥳. The biggest thx is to the people below, who made it all possible 😘. @mrclmb.bsky.social @caiuscollege.bsky.social Ready for postdoc!
January 26, 2025 at 4:03 PM
PhDone!!! So happy that I PASSED my viva! Major thx to outstanding examiners @juanquintana.bsky.social and @immunoah.bsky.social for giving me a run for my money 🥳. The biggest thx is to the people below, who made it all possible 😘. @mrclmb.bsky.social @caiuscollege.bsky.social Ready for postdoc!
I've always been passionate about outreach and social justice, especially when in science.
I wrote this article @nature.com to inspire others to generate similar initiatives. nature.com/articles/d41586-024-03562-4
I'll be sharing a new large-scale programme I'm launching soon. Stay tuned!
I wrote this article @nature.com to inspire others to generate similar initiatives. nature.com/articles/d41586-024-03562-4
I'll be sharing a new large-scale programme I'm launching soon. Stay tuned!
How I’m creating career opportunities for researchers back home in Mexico
David Posner hopes that his teaching and outreach programmes could apply to other low- and middle-income countries.
www.nature.com
January 12, 2025 at 8:24 PM
I've always been passionate about outreach and social justice, especially when in science.
I wrote this article @nature.com to inspire others to generate similar initiatives. nature.com/articles/d41586-024-03562-4
I'll be sharing a new large-scale programme I'm launching soon. Stay tuned!
I wrote this article @nature.com to inspire others to generate similar initiatives. nature.com/articles/d41586-024-03562-4
I'll be sharing a new large-scale programme I'm launching soon. Stay tuned!
Reposted by David Posner, PhD
Please join us for our January #GDTcellClub #gdTcells webinar with talks by Drs. Pedro Papotto and Victoria Stary.
Jan 16 @ 12pm (New York) | 5pm (London)
nyulangone.zoom.us/j/9589051706...
Zoom ID: 958 9051 7066
Passcode: 369081
@payalyokota.bsky.social @ph-papotto.bsky.social
Jan 16 @ 12pm (New York) | 5pm (London)
nyulangone.zoom.us/j/9589051706...
Zoom ID: 958 9051 7066
Passcode: 369081
@payalyokota.bsky.social @ph-papotto.bsky.social
January 11, 2025 at 4:35 PM
Please join us for our January #GDTcellClub #gdTcells webinar with talks by Drs. Pedro Papotto and Victoria Stary.
Jan 16 @ 12pm (New York) | 5pm (London)
nyulangone.zoom.us/j/9589051706...
Zoom ID: 958 9051 7066
Passcode: 369081
@payalyokota.bsky.social @ph-papotto.bsky.social
Jan 16 @ 12pm (New York) | 5pm (London)
nyulangone.zoom.us/j/9589051706...
Zoom ID: 958 9051 7066
Passcode: 369081
@payalyokota.bsky.social @ph-papotto.bsky.social
Reposted by David Posner, PhD
Exciting new pre print out now from @ph-papotto.bsky.social and @profjudiallen.bsky.social...
Bluesky-orial below!
Bluesky-orial below!
What a great way to start this account and end the week: our preprint describing how dermal γδ T cells mediate a skin-lung axis during parasite infection in mice is online! I'm excited to show the findings of my main postdoc project with @profjudiallen.bsky.social!🧵👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Migratory dermal gamma delta T cells determine the balance between lung immunity and tissue damage during Nippostrongylus brasiliensis infection
Many helminth parasites migrate through multiple host organs during infection but how immunity is regulated across these tissues is still poorly understood. To investigate the cellular and molecular a...
www.biorxiv.org
January 10, 2025 at 4:26 PM
Exciting new pre print out now from @ph-papotto.bsky.social and @profjudiallen.bsky.social...
Bluesky-orial below!
Bluesky-orial below!
My first week in my new job is done! Let's see what's next 😎
January 10, 2025 at 7:19 PM
My first week in my new job is done! Let's see what's next 😎
I'm so excited to announce that I've joined the @hepworth-lab.bsky.social in Manchester for my postdoc! So pumped to finally be here and ready to get some science done 🤩💪 @lydiabeckeriii.bsky.social
January 8, 2025 at 10:00 AM
I'm so excited to announce that I've joined the @hepworth-lab.bsky.social in Manchester for my postdoc! So pumped to finally be here and ready to get some science done 🤩💪 @lydiabeckeriii.bsky.social