Sébastien DARRAS
@darras-sebastien.bsky.social
Researcher at CNRS working on EvoDevo using #ascidians. #DEEVA team at the marine station in the beautiful Banyuls-sur-mer #WindyBanyuls
Pinned
Happy to share my last paper from my PhD work with the Deeva team! We establish new tools in European amphioxus: fertilized egg microinjection, F0 CRISPR/Cas9 mutagenesis & show Ascl1/2.1 is required for epidermal sensory neurons formation in amphioxus.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Towards functional genetics in the European amphioxus: efficient CRISPR/Cas9 editing reveals Ascl1/2.1 requirement for peripheral nervous system development.
Amphioxus, or cephalochordates, have a key phylogenetic position among chordates and serve as pivotal invertebrate models for investigating the evolut…
www.sciencedirect.com
Thank you @rafathchowdhury.bsky.social for your contribution to functional experiments in #amphioxus embryos @biom-banyuls.bsky.social of @obs-banyuls.fr in #WindyBanyuls. Novel and simple microinjection into fertilized eggs + efficient mutagenesis with Cas9/sgRNA RNP complex.
Reposted by Sébastien DARRAS
Bizarre Creature With 'All-Body Brain' Challenges What We Know About Evolution of Nervous Systems
Bizarre Creature With 'All-Body Brain' Challenges What We Know About Evolution of Nervous Systems
What other animals have we underestimated?
www.iflscience.com
November 12, 2025 at 8:54 PM
Bizarre Creature With 'All-Body Brain' Challenges What We Know About Evolution of Nervous Systems
Reposted by Sébastien DARRAS
[Message de service] Vous pensez/voulez postuler à un poste de Maître de Conférence ? Fort bien.
Avez-vous pensé à vous inscrire pour passer votre qualification ? C'est en ce moment qu'il faut aller s'inscrire en ligne... (odyssee.enseignementsup-recherche.gouv.fr)
Avez-vous pensé à vous inscrire pour passer votre qualification ? C'est en ce moment qu'il faut aller s'inscrire en ligne... (odyssee.enseignementsup-recherche.gouv.fr)
Odyssée
odyssee.enseignementsup-recherche.gouv.fr
October 13, 2025 at 10:22 AM
[Message de service] Vous pensez/voulez postuler à un poste de Maître de Conférence ? Fort bien.
Avez-vous pensé à vous inscrire pour passer votre qualification ? C'est en ce moment qu'il faut aller s'inscrire en ligne... (odyssee.enseignementsup-recherche.gouv.fr)
Avez-vous pensé à vous inscrire pour passer votre qualification ? C'est en ce moment qu'il faut aller s'inscrire en ligne... (odyssee.enseignementsup-recherche.gouv.fr)
Reposted by Sébastien DARRAS
Excited to share our recent work from @lowelab.bsky.social on the intersection of life history and cell type evolution: www.biorxiv.org/content/10.1...
www.biorxiv.org
November 6, 2025 at 10:03 PM
Excited to share our recent work from @lowelab.bsky.social on the intersection of life history and cell type evolution: www.biorxiv.org/content/10.1...
Reposted by Sébastien DARRAS
Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Single-nucleus profiling highlights the all-brain echinoderm nervous system
A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.
www.science.org
November 5, 2025 at 7:03 PM
Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Sébastien DARRAS
AAVs are crucial vectors for delivering biosensors into neurons! Using AAV delivery, we perform two-color imaging of calcium and potassium transients in neurons. These AAVs are now available from @braincase.bsky.social www.ebraincase.com/news/new-pro...
November 6, 2025 at 10:15 AM
AAVs are crucial vectors for delivering biosensors into neurons! Using AAV delivery, we perform two-color imaging of calcium and potassium transients in neurons. These AAVs are now available from @braincase.bsky.social www.ebraincase.com/news/new-pro...
Reposted by Sébastien DARRAS
Si le site avait vendu du matériel servant à des actes terroristes, les serveurs seraient déjà saisis, les dirigeants interpellés. Mais quand il s’agit de violences sexuelles faites aux enfants, on tergiverse, déplore Arnaud Gallais, président de Mouv’enfants.
➡️ bit.ly/3LtDfF0
➡️ bit.ly/3LtDfF0
November 5, 2025 at 1:01 PM
Si le site avait vendu du matériel servant à des actes terroristes, les serveurs seraient déjà saisis, les dirigeants interpellés. Mais quand il s’agit de violences sexuelles faites aux enfants, on tergiverse, déplore Arnaud Gallais, président de Mouv’enfants.
➡️ bit.ly/3LtDfF0
➡️ bit.ly/3LtDfF0
Reposted by Sébastien DARRAS
Could not be more happy/proud/relieved to finally see this longstanding study published. Bluetorial to follow. @msarscentre.bsky.social
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors | The EMBO Journal www.embopress.org/doi/full/10....
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors | The EMBO Journal www.embopress.org/doi/full/10....
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors | The EMBO Journal
imageimageDuring development, multipotent cardiopharyngeal progenitors express both cardiac
and pharyngeal muscle transcriptional programs. This study in the tunicate Ciona shows that cell cycle-regul...
www.embopress.org
November 4, 2025 at 6:05 AM
Could not be more happy/proud/relieved to finally see this longstanding study published. Bluetorial to follow. @msarscentre.bsky.social
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors | The EMBO Journal www.embopress.org/doi/full/10....
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors | The EMBO Journal www.embopress.org/doi/full/10....
Reposted by Sébastien DARRAS
The website for the 12th European Conference on #Echinoderms (London, July 2026) has gone live today. I am pleased to be involved as a member of the organising committee. Please spread the word: www.euroechino.net
12th European Echinoderm Meeting 2026
description
www.euroechino.net
November 4, 2025 at 5:45 PM
The website for the 12th European Conference on #Echinoderms (London, July 2026) has gone live today. I am pleased to be involved as a member of the organising committee. Please spread the word: www.euroechino.net
Reposted by Sébastien DARRAS
📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
October 30, 2025 at 1:15 PM
📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
Reposted by Sébastien DARRAS
Fully funded PhD position in my lab on the origin of the echinoderm skeletal ossicles. Join us in Montreal!
mapageweb.umontreal.ca/cameroc/Pubs...
mapageweb.umontreal.ca/cameroc/Pubs...
mapageweb.umontreal.ca
October 30, 2025 at 2:23 PM
Fully funded PhD position in my lab on the origin of the echinoderm skeletal ossicles. Join us in Montreal!
mapageweb.umontreal.ca/cameroc/Pubs...
mapageweb.umontreal.ca/cameroc/Pubs...
Reposted by Sébastien DARRAS
New preprint out! Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
Evolutionarily conserved transcriptional regulators control monoaminergic neuron development
To what extent conserved developmental programs specify homologous cell types is a central question in biology. Here, we address this by focusing on reconstructing monoaminergic neuron development in ...
doi.org
October 30, 2025 at 9:42 AM
New preprint out! Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
Reposted by Sébastien DARRAS
🔬 Applications are now open!
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Course Offerings | Marine Biological Laboratory
go.mbl.edu
October 28, 2025 at 6:08 PM
🔬 Applications are now open!
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Reposted by Sébastien DARRAS
#DBfeature
Scientists have identified a provisional regulatory circuit downstream of the transcription factor Pax3/7 operating in the descending decussating neurons (ddNs) of the tunicate Ciona robusta.
By Kim, K., Piekarz, K. M., & Stolfi, A.
doi.org/10.1016/j.yd...
Scientists have identified a provisional regulatory circuit downstream of the transcription factor Pax3/7 operating in the descending decussating neurons (ddNs) of the tunicate Ciona robusta.
By Kim, K., Piekarz, K. M., & Stolfi, A.
doi.org/10.1016/j.yd...
October 27, 2025 at 5:04 PM
#DBfeature
Scientists have identified a provisional regulatory circuit downstream of the transcription factor Pax3/7 operating in the descending decussating neurons (ddNs) of the tunicate Ciona robusta.
By Kim, K., Piekarz, K. M., & Stolfi, A.
doi.org/10.1016/j.yd...
Scientists have identified a provisional regulatory circuit downstream of the transcription factor Pax3/7 operating in the descending decussating neurons (ddNs) of the tunicate Ciona robusta.
By Kim, K., Piekarz, K. M., & Stolfi, A.
doi.org/10.1016/j.yd...
Reposted by Sébastien DARRAS
See you all in #BeautifulRoscoff next Spring 🙌🏻
I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
October 23, 2025 at 1:45 PM
See you all in #BeautifulRoscoff next Spring 🙌🏻
Reposted by Sébastien DARRAS
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 12:34 PM
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Reposted by Sébastien DARRAS
Sébastien Lecornu n’aura la garde du gouvernement qu’un week-end sur deux https://www.legorafi.fr/2025/10/15/sebastien-lecornu-naura-finalement-la-garde-du-gouvernement-quun-week-end-sur-deux/
Sébastien Lecornu n’aura la garde du gouvernement qu’un week-end sur deux
Toute l'information selon des sources contradictoires.
www.legorafi.fr
October 15, 2025 at 12:05 PM
Sébastien Lecornu n’aura la garde du gouvernement qu’un week-end sur deux https://www.legorafi.fr/2025/10/15/sebastien-lecornu-naura-finalement-la-garde-du-gouvernement-quun-week-end-sur-deux/
Reposted by Sébastien DARRAS
📣 SBIS, a new vital fluorescent probe for live imaging of #brownalgae #kelp in 4D. Just published in J. Cell Science by the Charrier team at the @igflyon.bsky.social. Download PDF on our team webpage here ➡️ shorturl.at/H5A9p
with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH
with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH
October 11, 2025 at 9:28 AM
📣 SBIS, a new vital fluorescent probe for live imaging of #brownalgae #kelp in 4D. Just published in J. Cell Science by the Charrier team at the @igflyon.bsky.social. Download PDF on our team webpage here ➡️ shorturl.at/H5A9p
with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH
with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH
Reposted by Sébastien DARRAS
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by Sébastien DARRAS
Developmental Biology lost a giant yesterday 😔
May his legacy thrive and keep inspiring current and future generations of scientists
www.gurdon.cam.ac.uk/nobel-laurea...
May his legacy thrive and keep inspiring current and future generations of scientists
www.gurdon.cam.ac.uk/nobel-laurea...
Nobel Laureate Professor Sir John Gurdon Dies Aged 92 – Gurdon Institute
www.gurdon.cam.ac.uk
October 8, 2025 at 6:26 PM
Developmental Biology lost a giant yesterday 😔
May his legacy thrive and keep inspiring current and future generations of scientists
www.gurdon.cam.ac.uk/nobel-laurea...
May his legacy thrive and keep inspiring current and future generations of scientists
www.gurdon.cam.ac.uk/nobel-laurea...
Reposted by Sébastien DARRAS
🚨 My lab is hiring at all levels!
Interested in animal origins & evolutionary cell biology?
I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.
🔗: clarkelab.com/join/
Please repost!
Interested in animal origins & evolutionary cell biology?
I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.
🔗: clarkelab.com/join/
Please repost!
October 8, 2025 at 5:49 PM
🚨 My lab is hiring at all levels!
Interested in animal origins & evolutionary cell biology?
I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.
🔗: clarkelab.com/join/
Please repost!
Interested in animal origins & evolutionary cell biology?
I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.
🔗: clarkelab.com/join/
Please repost!
Reposted by Sébastien DARRAS
Est-ce qu’on peut avoir une projection actualisée ? @ninimacbright.bsky.social
Le prochain durera 12 min et 56 secondes ? 🤓
Le prochain durera 12 min et 56 secondes ? 🤓
J'ai étudié le nombre de jours passés à Matignon par tous les Premiers Ministres de Macron, et je peux vous affirmer que le prochain gouvernement durera très exactement 2 jours, 11 heures et 27 minutes
October 6, 2025 at 9:13 AM
Est-ce qu’on peut avoir une projection actualisée ? @ninimacbright.bsky.social
Le prochain durera 12 min et 56 secondes ? 🤓
Le prochain durera 12 min et 56 secondes ? 🤓
A l'occasion de la fête de la science 2025 #FDS2025, venez découvrir les recherches de l'équipe #DEEVA avec l'atelier Aqu'ascidie.
Superbe dessin par @cecileleblond.bsky.social !
Le programme est ici: www.obs-banyuls.fr/fr/partager/...
Superbe dessin par @cecileleblond.bsky.social !
Le programme est ici: www.obs-banyuls.fr/fr/partager/...
September 30, 2025 at 8:29 AM
A l'occasion de la fête de la science 2025 #FDS2025, venez découvrir les recherches de l'équipe #DEEVA avec l'atelier Aqu'ascidie.
Superbe dessin par @cecileleblond.bsky.social !
Le programme est ici: www.obs-banyuls.fr/fr/partager/...
Superbe dessin par @cecileleblond.bsky.social !
Le programme est ici: www.obs-banyuls.fr/fr/partager/...
September 29, 2025 at 3:38 PM
Reposted by Sébastien DARRAS
Congratulations to Oğuz Akar who was awarded the title of Doctor in Philosophy in Cell and Biology yesterday!
September 26, 2025 at 11:37 AM
Congratulations to Oğuz Akar who was awarded the title of Doctor in Philosophy in Cell and Biology yesterday!
Reposted by Sébastien DARRAS
Sea urchin metamorphosis is maybe one of the most radical event in developmental biology. In just about an hour, these little pluteus larvae completely reorganize their entire body plan.
Very happy that this video got awarded an honorable mention by #NikonSmallWorld 😃
Very happy that this video got awarded an honorable mention by #NikonSmallWorld 😃
September 26, 2025 at 12:56 AM
Sea urchin metamorphosis is maybe one of the most radical event in developmental biology. In just about an hour, these little pluteus larvae completely reorganize their entire body plan.
Very happy that this video got awarded an honorable mention by #NikonSmallWorld 😃
Very happy that this video got awarded an honorable mention by #NikonSmallWorld 😃