btw, there's a curious tandem duplication event found in certain primates including humans but not in mice at the NANOG locus. #stemcells #hPSCs

Jielin Yan (recently graduated 🎉🎉) led the discovery of two enhancers regulating NANOG expression in #hESCs via a #CRISPRi screen. It's part of our larger effort characterizing the functions of enhancers and noncoding variant in development and disease @igvfconsortium.bsky.social

if a non-monotonic response is intriguing to you, stay tuned for another preprint from Jielin on gene dosage responses ...

I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...