Jargon-free summaries of the work provided here by @kidneyresearchuk.org: www.kidneyresearchuk.org/2025/09/16/t...

and @sangerinstitute.bsky.social: www.sanger.ac.uk/news_item/ki...

4/4

The project was started back in 2019 with generous funding from @kidneyresearchuk.org, @wellcometrust.bsky.social and @greatormondst.bsky.social Biomedical Research Centre

3/4

This was a huge team effort between @uclpress.bsky.social, @sangerinstitute.bsky.social and @cam.ac.uk

Special thanks to senior authors Menna Clatworthy, Reza Motallebzadeh and David Long for facilitating this project

And to all the patients and families who shaped and inspired this work

2/4

And last (but definitely not least) thanks to the amazing scientists at David Long’s lab at UCL, who worked hard to wrap up this work whilst I stumble through clinical training (4/4)

Thanks to our collaborators, especially the Ruhrberg Lab at UCL, the Riley Lab at Oxford, @siegenthalerlab.bsky.social and others for providing the support to make this work a reality. We are generous for funding from @goshcharity.bsky.social, @wellcometrust.bsky.social & @kidneyresearchuk.org (3/4)

A UCL Bogue Fellowship enabled me to travel to the Rosenblum Lab @uoftpress.bsky.social in Canada to complete these experiments, which opened up a new collaboration between two internationally recognised centres in childhood kidney disease, @greatormondst.bsky.social & @sickkidsto.bsky.social (2/4)

I’m grateful for the mentors and colleagues (many who aren’t yet on this platform 👀), who have all collectively given me the support, guidance and motivation I needed to get here

Always looking for new collaborations and ideas, if you’re interested in teaming up then please reach out! 🙌🏽
(4/4)

I’m so grateful for this opportunity - it supports building a research agenda and, in parallel, allows me to continue clinical and leadership training

There are very few such opportunities for those who want to integrate post-doc research w. very early clinical training. I hope this changes!
(3/4)

I am also linking up with the MBPhD programme, from which I graduated, to support and mentor current students and recent grads

Ultimately, I want to find ways to amplify MBPhD students in the UK and help them navigate the barriers to becoming clinician- / surgeon-scientists. Watch this space!
(2/4)

These findings reveal a window for interventions to restore the microvasculature

Thanks to our many collaborators, our funders (@kidneyresearchuk.org, the UK PKD Charity, @wellcometrust.bsky.social, The Rosetrees Trust, The Foulkes Foundation) & to the patients and relatives who motivate us (5/5)

We found that the kidney microvasculature in humans with PKD has a unique molecular fingerprint. In mice, abnormalities of the kidney microvasculature occurred early (like the striking results in this image). Importantly, these changes occurred before irreversible damage set in (4/5)