Daniyal Jafree
@daniyaljafree.bsky.social
Resident FY2 doctor at Cambridge University Hospitals
Postdoc scientist at UCL and the Wellcome Trust Sanger Institute
Alumnus of the UCL MB/PhD Programme
Studying vasculature and lymphatics in development and disease
Postdoc scientist at UCL and the Wellcome Trust Sanger Institute
Alumnus of the UCL MB/PhD Programme
Studying vasculature and lymphatics in development and disease
Pinned
Daniyal Jafree
@daniyaljafree.bsky.social
· Sep 17
🚨 New paper in @jclinical-invest.bsky.social!
Kidney lymphatics are a promising target in transplant rejection
🗺️ In rejection, lymphatics expand and adversely remodel
⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system
www.jci.org/articles/vie...
1/4
Kidney lymphatics are a promising target in transplant rejection
🗺️ In rejection, lymphatics expand and adversely remodel
⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system
www.jci.org/articles/vie...
1/4
Reposted by Daniyal Jafree
For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.
September 26, 2025 at 5:51 PM
For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.
Reposted by Daniyal Jafree
Kidney transplant rejection linked to changes in lymphatic vessels
Researchers found that when a kidney transplant is rejected, the lymphatic vessels around the transplanted kidney undergo changes, making it easier for the immune system to attack the new organ.
www.ucl.ac.uk/news/2025/se...
Researchers found that when a kidney transplant is rejected, the lymphatic vessels around the transplanted kidney undergo changes, making it easier for the immune system to attack the new organ.
www.ucl.ac.uk/news/2025/se...
Kidney transplant rejection linked to changes in lymphatic vessels
A link between kidney transplant rejection and changes in the body’s lymphatic vessels has been discovered in a UCL-led study.
www.ucl.ac.uk
September 22, 2025 at 3:16 PM
Kidney transplant rejection linked to changes in lymphatic vessels
Researchers found that when a kidney transplant is rejected, the lymphatic vessels around the transplanted kidney undergo changes, making it easier for the immune system to attack the new organ.
www.ucl.ac.uk/news/2025/se...
Researchers found that when a kidney transplant is rejected, the lymphatic vessels around the transplanted kidney undergo changes, making it easier for the immune system to attack the new organ.
www.ucl.ac.uk/news/2025/se...
Reposted by Daniyal Jafree
Take a peek: This issue’s cover features 3D imaging and single-cell genomics by David A. Long @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az
September 20, 2025 at 12:04 PM
Take a peek: This issue’s cover features 3D imaging and single-cell genomics by David A. Long @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az
Reposted by Daniyal Jafree
Study pinpoints reason why transplanted kidneys can be rejected.
Research by Prof David Long, @daniyaljafree.bsky.social (@uclchildhealth.bsky.social) and colleagues @greatormondst.bsky.social, Wellcome Sanger and University of Cambridge.
bit.ly/47NIU1V
@uclpophealthsci.bsky.social
Research by Prof David Long, @daniyaljafree.bsky.social (@uclchildhealth.bsky.social) and colleagues @greatormondst.bsky.social, Wellcome Sanger and University of Cambridge.
bit.ly/47NIU1V
@uclpophealthsci.bsky.social
Study pinpoints reason why transplanted kidneys can be rejected, scientists say
Experts used new imaging techniques to look at the organ’s ‘plumbing system’ to understand what these vessels do during transplantation.
www.independent.co.uk
September 17, 2025 at 2:20 PM
Study pinpoints reason why transplanted kidneys can be rejected.
Research by Prof David Long, @daniyaljafree.bsky.social (@uclchildhealth.bsky.social) and colleagues @greatormondst.bsky.social, Wellcome Sanger and University of Cambridge.
bit.ly/47NIU1V
@uclpophealthsci.bsky.social
Research by Prof David Long, @daniyaljafree.bsky.social (@uclchildhealth.bsky.social) and colleagues @greatormondst.bsky.social, Wellcome Sanger and University of Cambridge.
bit.ly/47NIU1V
@uclpophealthsci.bsky.social
Reposted by Daniyal Jafree
An in-depth look at lymphatic reorganization!
This issue’s cover features 3D imaging and single-cell genomics by David A. Long, @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az
This issue’s cover features 3D imaging and single-cell genomics by David A. Long, @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az
September 16, 2025 at 4:05 PM
An in-depth look at lymphatic reorganization!
This issue’s cover features 3D imaging and single-cell genomics by David A. Long, @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az
This issue’s cover features 3D imaging and single-cell genomics by David A. Long, @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az
🚨 New paper in @jclinical-invest.bsky.social!
Kidney lymphatics are a promising target in transplant rejection
🗺️ In rejection, lymphatics expand and adversely remodel
⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system
www.jci.org/articles/vie...
1/4
Kidney lymphatics are a promising target in transplant rejection
🗺️ In rejection, lymphatics expand and adversely remodel
⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system
www.jci.org/articles/vie...
1/4
September 17, 2025 at 12:32 PM
🚨 New paper in @jclinical-invest.bsky.social!
Kidney lymphatics are a promising target in transplant rejection
🗺️ In rejection, lymphatics expand and adversely remodel
⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system
www.jci.org/articles/vie...
1/4
Kidney lymphatics are a promising target in transplant rejection
🗺️ In rejection, lymphatics expand and adversely remodel
⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system
www.jci.org/articles/vie...
1/4
Reposted by Daniyal Jafree
First of its kind study for children with arthritis reveals possible new disease targets.
Researchers have been able to see what happens in the inflamed joints of children with arthritis, giving insight into why treatments affect children differently. Read: www.ucl.ac.uk/news/2025/ju...
Researchers have been able to see what happens in the inflamed joints of children with arthritis, giving insight into why treatments affect children differently. Read: www.ucl.ac.uk/news/2025/ju...
First of its kind study for children with arthritis reveals possible new disease targets
Researchers have been able to see what happens in the inflamed joints of children with arthritis, giving insight into why treatments affect children differently.
www.ucl.ac.uk
July 4, 2025 at 9:42 AM
First of its kind study for children with arthritis reveals possible new disease targets.
Researchers have been able to see what happens in the inflamed joints of children with arthritis, giving insight into why treatments affect children differently. Read: www.ucl.ac.uk/news/2025/ju...
Researchers have been able to see what happens in the inflamed joints of children with arthritis, giving insight into why treatments affect children differently. Read: www.ucl.ac.uk/news/2025/ju...
Reposted by Daniyal Jafree
I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!
July 26, 2025 at 12:17 PM
I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!
Excited to share our new collaborative preprint between @uclnews.bsky.social and @sickkidsto.bsky.social 🥳
We found that kidney lymphatic vessels, an emerging target in kidney diseases, partly arises from the same group of cells that give rise to the kidney
www.biorxiv.org/content/10.1...
(1/4)
We found that kidney lymphatic vessels, an emerging target in kidney diseases, partly arises from the same group of cells that give rise to the kidney
www.biorxiv.org/content/10.1...
(1/4)
Genetic lineage tracing identifies intermediate mesoderm as a novel contributor to mammalian kidney lymphatics
The lymphatic vasculature is essential for fluid homeostasis, immune regulation and possesses diverse organ-specific functions. During development, lymphatic endothelial cells (LEC) arise from multipl...
www.biorxiv.org
July 22, 2025 at 8:17 PM
Excited to share our new collaborative preprint between @uclnews.bsky.social and @sickkidsto.bsky.social 🥳
We found that kidney lymphatic vessels, an emerging target in kidney diseases, partly arises from the same group of cells that give rise to the kidney
www.biorxiv.org/content/10.1...
(1/4)
We found that kidney lymphatic vessels, an emerging target in kidney diseases, partly arises from the same group of cells that give rise to the kidney
www.biorxiv.org/content/10.1...
(1/4)
Reposted by Daniyal Jafree
🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)
Job Details
my.corehr.com
July 7, 2025 at 2:43 PM
🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)
Reposted by Daniyal Jafree
PhD position available in our team @dublincityuni.bsky.social from September. Please share/ contact me for informal enquiries.
July 7, 2025 at 3:55 PM
PhD position available in our team @dublincityuni.bsky.social from September. Please share/ contact me for informal enquiries.
Reposted by Daniyal Jafree
For #FluorescenceFriday I'm sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/full/10....
June 20, 2025 at 8:06 PM
For #FluorescenceFriday I'm sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/full/10....
Reposted by Daniyal Jafree
Thrilled to share our new work in Nature Communications!
We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics
Here’s a quick breakdown
www.nature.com/articles/s41...
We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics
Here’s a quick breakdown
www.nature.com/articles/s41...
An RNA transmethylation pathway governs kidney nephrogenic potential - Nature Communications
The mechanisms governing kidney nephrogenic capacity are incompletely understood. Here, the authors reveal that METTL3-dependent RNA transmethylation is both necessary and sufficient to promote nephro...
www.nature.com
May 28, 2025 at 8:18 PM
Thrilled to share our new work in Nature Communications!
We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics
Here’s a quick breakdown
www.nature.com/articles/s41...
We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics
Here’s a quick breakdown
www.nature.com/articles/s41...
Delighted to be a Accelerator Award recipient @wellcometrust.bsky.social 🥳
I’ll work at @uclnews.bsky.social + @sangerinstitute.bsky.social, diving into how lymphatic vessels regulate immunity, whilst building clinical experience at @greatormondst.bsky.social
wellcome.org/grant-fundin...
(1/4)
I’ll work at @uclnews.bsky.social + @sangerinstitute.bsky.social, diving into how lymphatic vessels regulate immunity, whilst building clinical experience at @greatormondst.bsky.social
wellcome.org/grant-fundin...
(1/4)
Organ-specific lymphatic endothelial heterogeneity in tissue homeostasis and allergic inflammation - Grants Awarded | Wellcome
Organ-specific lymphatic endothelial heterogeneity in tissue homeostasis and allergic inflammation
wellcome.org
April 2, 2025 at 10:50 PM
Delighted to be a Accelerator Award recipient @wellcometrust.bsky.social 🥳
I’ll work at @uclnews.bsky.social + @sangerinstitute.bsky.social, diving into how lymphatic vessels regulate immunity, whilst building clinical experience at @greatormondst.bsky.social
wellcome.org/grant-fundin...
(1/4)
I’ll work at @uclnews.bsky.social + @sangerinstitute.bsky.social, diving into how lymphatic vessels regulate immunity, whilst building clinical experience at @greatormondst.bsky.social
wellcome.org/grant-fundin...
(1/4)
Thrilled to share a new paper from my PhD in David Long’s lab at UCL, published in the Disease Models & Mechanisms journal!
doi.org/10.1242/dmm....
We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)
doi.org/10.1242/dmm....
We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)
March 27, 2025 at 11:14 PM
Thrilled to share a new paper from my PhD in David Long’s lab at UCL, published in the Disease Models & Mechanisms journal!
doi.org/10.1242/dmm....
We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)
doi.org/10.1242/dmm....
We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)