#epigenomics #epigenetics #singlecell #chromatin
https://www.linkedin.com/in/damian-toczydlowski/
➡️ Mendel, memories and meaning. Nat Genet 54, 907 (2022).
DOI: doi.org/10.1038/s415...
➡️ Mendel, memories and meaning. Nat Genet 54, 907 (2022).
DOI: doi.org/10.1038/s415...
Do you recall the story of Gregor Mendel, the monk?
Yes, that man, who with relentless passion, crossbred his pea plants in the quiet gardens of the Augustinian monastery.
#science #genetics
DOI: doi.org/10.1016/j.xg...
www.sciencedirect.com/science/arti...
DOI: doi.org/10.1016/j.xg...
www.sciencedirect.com/science/arti...
It might sound like science fiction...
But your cells actually have a form of memory.
Not the kind you use to remember your grocery list, but something far more sophisticated.
#epigenetics #science #genomics
It might sound like science fiction...
But your cells actually have a form of memory.
Not the kind you use to remember your grocery list, but something far more sophisticated.
#epigenetics #science #genomics
At some point, once scientists started exploring cellular epigenomes in more detail, they hit a glass ceiling.
What slowed down the progress?
#epigenetics #genomics #crispr
At some point, once scientists started exploring cellular epigenomes in more detail, they hit a glass ceiling.
What slowed down the progress?
#epigenetics #genomics #crispr
DOI: doi.org/10.1016/j.ce...
DOI: doi.org/10.1016/j.ce...
One of the biggest surprises for geneticists came when they started breaking down the sequence of human DNA into its constituent parts.
Do you know how it went at the beginning?
#epigenetics #genomics #science
One of the biggest surprises for geneticists came when they started breaking down the sequence of human DNA into its constituent parts.
Do you know how it went at the beginning?
#epigenetics #genomics #science
DOI: doi.org/10.1073/pnas...
DOI: doi.org/10.1073/pnas...
I will only say that we haven't had a breakthrough like this in a long time.
#regenerativemedicine #stemcells #science
I will only say that we haven't had a breakthrough like this in a long time.
#regenerativemedicine #stemcells #science
DOI: doi.org/10.1016/j.ce...
DOI: doi.org/10.1016/j.ce...
Our DNA – probably one of the most valuable resources that we possess – is packed in our cells in a fantastic, clever way.
#epigenetics #genomics #chromatin
Our DNA – probably one of the most valuable resources that we possess – is packed in our cells in a fantastic, clever way.
#epigenetics #genomics #chromatin
Until a certain point in the history of molecular biology, methods for DNA & RNA sequencing were developed separately.
#epigenetics #epigenomics #genomics
Until a certain point in the history of molecular biology, methods for DNA & RNA sequencing were developed separately.
#epigenetics #epigenomics #genomics
DOI: doi.org/10.1016/j.ym...
DOI: doi.org/10.1016/j.ym...
Gene therapies wouldn't exist if we couldn't sequence the human genome.
They wouldn't exist without the breakthroughs in genome editing or the methods to deliver what some call "fixed genes" into patients' bodies.
#genetherapy
Gene therapies wouldn't exist if we couldn't sequence the human genome.
They wouldn't exist without the breakthroughs in genome editing or the methods to deliver what some call "fixed genes" into patients' bodies.
#genetherapy
"Sire, Your Grace, genome, tell us who we truly are," they said.
At one time, scientists thought that sequencing the human genome would mark the end of a certain era in history.
#genomics #epigenetics
"Sire, Your Grace, genome, tell us who we truly are," they said.
At one time, scientists thought that sequencing the human genome would mark the end of a certain era in history.
#genomics #epigenetics
Lee, T. I., & Young, R. A. (2013). Transcriptional regulation and its misregulation in disease. Cell, 152(6), 1237–1251.
DOI: doi.org/10.1016/j.ce...
Lee, T. I., & Young, R. A. (2013). Transcriptional regulation and its misregulation in disease. Cell, 152(6), 1237–1251.
DOI: doi.org/10.1016/j.ce...
Transcription?
For some, it is just a meaningless word.
To others?
A molecular process.
#transcriptomics #epigenetics #genomics
Transcription?
For some, it is just a meaningless word.
To others?
A molecular process.
#transcriptomics #epigenetics #genomics
Nucleic acids are neither "immortal" nor made of iron.
They can't be endlessly damaged.
#genomics #epigenetics
Nucleic acids are neither "immortal" nor made of iron.
They can't be endlessly damaged.
#genomics #epigenetics
This epigenome editing makes a difference for all genomic scientists, especially those who are scratching their heads trying to design effective gene therapies.
#epigenetics #CRISPR #genomics
This epigenome editing makes a difference for all genomic scientists, especially those who are scratching their heads trying to design effective gene therapies.
#epigenetics #CRISPR #genomics
Cancer has an increased tendency to accumulate genomic alterations, a phenomenon scientists call "𝐠𝐞𝐧𝐨𝐦𝐢𝐜 𝐢𝐧𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲".
#epigenetics #cancer #genomics
Cancer has an increased tendency to accumulate genomic alterations, a phenomenon scientists call "𝐠𝐞𝐧𝐨𝐦𝐢𝐜 𝐢𝐧𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲".
#epigenetics #cancer #genomics
Cancer is simply inhuman.
Why can a single, mutated cell become a life-threatening danger to a human being?
How can it destroy the entire organism, it belongs to.
#epigenetics #cancer #genomics
Cancer is simply inhuman.
Why can a single, mutated cell become a life-threatening danger to a human being?
How can it destroy the entire organism, it belongs to.
#epigenetics #cancer #genomics
It might sound a bit puzzling...
But not every cell with a specific set of oncogenic mutations actually transforms into a cancerous cell.
#epigenetics #cancer #genomics
It might sound a bit puzzling...
But not every cell with a specific set of oncogenic mutations actually transforms into a cancerous cell.
#epigenetics #cancer #genomics
Even things as complex as thinking, forming memories, or making logical connections all come down to how our genes react to different stimuli.
#epigenetics #genomics #science
Even things as complex as thinking, forming memories, or making logical connections all come down to how our genes react to different stimuli.
#epigenetics #genomics #science