Dame lab at Leiden University
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Dame lab at Leiden University
@damelab.bsky.social
280 followers 400 following 25 posts
Interested in the organisation of chromatin in bacteria and archaea, its interplay with transcription and evolution. Methods: single-molecule and ensemble biochemistry, genetics, molecular microbiology, 3D genomics, (computational) structural biology.
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Dame lab at Leiden University @damelab.bsky.social · 6d
Thanks a lot, Harsh!
Dame lab at Leiden University @damelab.bsky.social · 6d
New article online: Modulation of archaeal hypernucleosome structure and stability by Mg2+

In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB).

www.sciencedirect.com/science/arti...
Modulation of archaeal hypernucleosome structure and stability by Mg2+
DNA-wrapping histone proteins play a central role in chromatin organization, gene expression and regulation in most eukaryotes and archaea. While the …
www.sciencedirect.com
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Dame lab at Leiden University @damelab.bsky.social · 6d
Soon available in my group: 1 PhD position to investigate prokaryotic histones. See our recent work that highlights the existence and diversity of prokaryotic histones (e.g. Schwab et al., TIBS, 2025; Schwab et al., Nat Comm, 2024; Hu et al., Nucl Acids Res, 2024). Please DM for informal enquiries.
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dodonova-sveta.bsky.social
Svetlana Dodonova @dodonova-sveta.bsky.social · 14d
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
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biochemsoc.bsky.social
Biochemical Society @biochemsoc.bsky.social · Sep 19
That’s a wrap for The Biology and Physics of Prokaryotic Chromosomes VII 2025. A big thank you to all those who attended 🧪 #BioPhyChrom2025 #BiochemEvents
Group photo
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Dame lab at Leiden University @damelab.bsky.social · Sep 15
Tomorrow is the start of Biology and Physics of Prokaryotic Chromosomes VII. Great speakers and participants. Excellent support by the Biochem. Society. @biochemsoc.bsky.social
@danielabarilla.bsky.social @vslioy.bsky.social
@graingerlab.bsky.social
@damelab.bsky.social
#BioPhyChrom2025
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Dame lab at Leiden University @damelab.bsky.social · Sep 15
DNA bridging has also been established as a DNA binding mode shared by many architectural proteins across the domains of life, with DNA bridging histone proteins in archaea as latest highlight.
Dame lab at Leiden University @damelab.bsky.social · Sep 15
Research in many different labs has revealed that DNA bridging is key to many of its functions in vivo. 2.5 decades later novel functions of H-NS and mechanisms of functional modulation are still being discovered.
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Dame lab at Leiden University @damelab.bsky.social · Sep 15
Time flies .. it is today 25 years ago that we published our studies that revealed that bacterial H-NS is a DNA bridging protein:
academic.oup.com/nar/article/... @narjournal.bsky.social
H-NS mediated compaction of DNA visualised by atomic force microscopy
Abstract. The Escherichia coli H-NS protein is a nucleoid-associated protein involved in gene regulation and DNA compaction. To get more insight into the m
academic.oup.com
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danielabarilla.bsky.social
Daniela Barillà @danielabarilla.bsky.social · Sep 8
One week to go for The Biology & Physics of Chromosomes VII, but there is still time to register!
Join us! 🧬🧬🧬

@biophychrom.bsky.social @biochemsoc.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @damelab.bsky.social
River Ouse in York and the Hospitium, the conference banquet venue.
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tobiaswarnecke.bsky.social
Tobias Warnecke @tobiaswarnecke.bsky.social · Sep 1
Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...
Supervisors and Projects
www.bioch.ox.ac.uk
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graingerlab.bsky.social
Grainger Lab @graingerlab.bsky.social · Jul 25
Talk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫

www.eventsforce.net/biochemsoc/f...

@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
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Dame lab at Leiden University @damelab.bsky.social · Jul 23
Great to see it published, Daniela!
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danielabarilla.bsky.social
Daniela Barillà @danielabarilla.bsky.social · Jul 14
Just few days left to register for this chromosome biology fête! 🧬🧬🧬

⏳📆 16 July

www.eventsforce.net/biochemsoc/f...

@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
Poster advertising the Biology and Physics of Prokaryotic Chromosomes conference that will be held in York, 16-19 September 2025.
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Dame lab at Leiden University @damelab.bsky.social · Jul 10
I am pleased to share our new review on the role of bacterial nucleoid-aasociated proteins in mediating responses to changes in environment. Important: some NAPs can directly ‘sense’ physico-chemical changes. www.sciencedirect.com/science/arti... @pingzhuangge.bsky.social
The role of nucleoid-associated proteins in mediating responses to environmental changes
Bacteria face diverse environmental challenges, such as changes in temperature, pH, and osmolarity, and exposure to antibiotics, which necessitate ada…
www.sciencedirect.com
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danielabarilla.bsky.social
Daniela Barillà @danielabarilla.bsky.social · Jul 2
York calling! 📣 🧬🧬🧬

Join us at www.biochemistry.org/events-and-t...

⏳⏰ Early bird deadline approaching soon, 16 July! Do not miss out! Half of the talks selected from abstracts.
@damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
View of a street in York with old houses on both sides and the towers of York Minster in the background.
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Dame lab at Leiden University @damelab.bsky.social · Jun 30
A must-read for histone afficionados: our new review on 'Histone-mediated chromatin organization in prokaryotes and viruses' www.cell.com/trends/bioch... @samuelschwab.bsky.social @vikramalva.bsky.social
Histone-mediated chromatin organization in prokaryotes and viruses
Histones are fundamental chromatin-organizing proteins in eukaryotes and archaea, where they assemble into (hyper)nucleosomes that wrap DNA. Recent studies have expanded the known repertoire of histon...
www.cell.com
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danielabarilla.bsky.social
Daniela Barillà @danielabarilla.bsky.social · Jun 11
Chromosome Enthusiasts, join us at The Biology & Physics of Prokaryotic Chromosomes 🧬! Friendly community, fantastic speakers line-up, grant writing session for ECRs. Early-bird deadline approaching soon.
@damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biophychrom.bsky.social
Flyer advertising The Biology and Physics of Prokaryotic Chromosome conference that will be held in York, 16-19 September 2025.
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dodonova-sveta.bsky.social
Svetlana Dodonova @dodonova-sveta.bsky.social · May 26
We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
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Dame lab at Leiden University @damelab.bsky.social · May 26
So very nice to see the pre-print online - it’s a beautiful story! We’re happy to have been involved.
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danielabarilla.bsky.social
Daniela Barillà @danielabarilla.bsky.social · May 15
Join us in York for the Biology & Physics of Prokaryotic Chromosomes! 🧬 #Microsky #Archaeasky

www.biochemistry.org/events-and-t...
@biochemsoc.bsky.social
@damelab.bsky.social @graingerlab.bsky.social @vslioy.bsky.social
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danieltamarit.bsky.social
Daniel Tamarit @danieltamarit.bsky.social · May 14
New vacancy in my team!

PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture.

Please repost and share with talented MSc students in #evobio, bioinformatics or related :)

www.uu.nl/en/organisat...

#MEvoSky #MicroSky
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Dame lab at Leiden University @damelab.bsky.social · May 12
It’s great to see this online. We are very glad to have been able to contribute to this work on yet an other very interesting type of bacterial histone.
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vikramalva.bsky.social
Vikram Alva @vikramalva.bsky.social · May 12
Excited to share our new preprint on HLp—a bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone" www.biorxiv.org/content/10.1...

@mpi-bio-fml.bsky.social
A snapshot of the HLp tetramer (purple) wrapping ~60 bp of DNA (green).
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molecularmicro.bsky.social
Molecular Microbiology Editors @molecularmicro.bsky.social · Mar 11
Chromatin aficionados take note:
Second of two special issues on Prokaryotic Chromosome Organization now published!
(6 review/perspective articles and 2 research articles)
Guest edited by @damelab.bsky.social
#MicroSky #Chromatin

onlinelibrary.wiley.com/toc/13652958...
Prokaryotic Chromosome Organization: part 2: Molecular Microbiology: Vol 123, No 3
Molecular Microbiology is a broad-scope microbiology journal for basic and translational research that contributes to understanding molecular principles in microbes.
onlinelibrary.wiley.com
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