David Cagan
@dacagan.bsky.social
Postdoc in Baran Lab @ Scripps Research | PhD in Hadt Lab @ Caltech CCE | NASEM Ford Fellow & NSF GRFP Fellow | (he/him) | Founding Director of Caltech’s Rising Tide Program
https://orcid.org/0000-0002-4719-2789
https://orcid.org/0000-0002-4719-2789
Temperature scanning reaction calorimetry allowed us gather a near-continuous set of rate constants (thousands !!) for our redox-neutral radical cross-coupling reactions.
Then with our new mechanistic insights, we kinetically matched hydrazides with (Het)ArX to boost rxn yields up to 7x!
Then with our new mechanistic insights, we kinetically matched hydrazides with (Het)ArX to boost rxn yields up to 7x!
September 18, 2025 at 6:42 PM
Temperature scanning reaction calorimetry allowed us gather a near-continuous set of rate constants (thousands !!) for our redox-neutral radical cross-coupling reactions.
Then with our new mechanistic insights, we kinetically matched hydrazides with (Het)ArX to boost rxn yields up to 7x!
Then with our new mechanistic insights, we kinetically matched hydrazides with (Het)ArX to boost rxn yields up to 7x!
April 25, 2025 at 12:54 AM
Reposted by David Cagan
Stereoretentive Radical Cross-Coupling
Authors: Jiawei Sun, Jiayan He, Luca Massaro, David Cagan, Jet Tsien, Yu Wang, Flynn Attard, Jillian Smith, Jason Lee, Yu Kawamata, Phil Baran
DOI: 10.26434/chemrxiv-2025-h9snj
Authors: Jiawei Sun, Jiayan He, Luca Massaro, David Cagan, Jet Tsien, Yu Wang, Flynn Attard, Jillian Smith, Jason Lee, Yu Kawamata, Phil Baran
DOI: 10.26434/chemrxiv-2025-h9snj
March 17, 2025 at 5:24 AM
Stereoretentive Radical Cross-Coupling
Authors: Jiawei Sun, Jiayan He, Luca Massaro, David Cagan, Jet Tsien, Yu Wang, Flynn Attard, Jillian Smith, Jason Lee, Yu Kawamata, Phil Baran
DOI: 10.26434/chemrxiv-2025-h9snj
Authors: Jiawei Sun, Jiayan He, Luca Massaro, David Cagan, Jet Tsien, Yu Wang, Flynn Attard, Jillian Smith, Jason Lee, Yu Kawamata, Phil Baran
DOI: 10.26434/chemrxiv-2025-h9snj
Reposted by David Cagan
Out First Release in @science.org today, Phil Baran's group in collaboration with BMS and Pfizer showcase a wide range of cross-couplings facilitated by sulfonyl hydrazides--no external redox required
Chemsky 🧪
www.science.org/doi/10.1126/...
Chemsky 🧪
www.science.org/doi/10.1126/...
Sulfonyl hydrazides as a general redox-neutral platform for radical cross-coupling
www.science.org
March 6, 2025 at 8:12 PM
Out First Release in @science.org today, Phil Baran's group in collaboration with BMS and Pfizer showcase a wide range of cross-couplings facilitated by sulfonyl hydrazides--no external redox required
Chemsky 🧪
www.science.org/doi/10.1126/...
Chemsky 🧪
www.science.org/doi/10.1126/...
Reposted by David Cagan
guys being a postdoc is so cool. I have spent my entire life wanting to be an academic and this has really locked it in for me. self doubt inherent in any competitive field aside, this is genuinely the most fun and exciting and interesting job I’ve ever had
November 16, 2024 at 7:53 PM
guys being a postdoc is so cool. I have spent my entire life wanting to be an academic and this has really locked it in for me. self doubt inherent in any competitive field aside, this is genuinely the most fun and exciting and interesting job I’ve ever had