Sandro Da Mesquita
@da-mesquita.bsky.social
Assistant Professor | Dept. of Neuroscience @ Mayo Clinic | Understanding the role of the meningeal lymphatic system in CNS aging & degeneration 🤓🧠🧪🔬 | Views=own.
https://www.mayo.edu/research/labs/meningeal-lymphatics-neurological-disorders
https://www.mayo.edu/research/labs/meningeal-lymphatics-neurological-disorders
Pinned
CSF transport at the brain–meningeal border: effects on neurological health and disease
The existence of specialised structures that allow a continuous exchange of CSF between
different anatomical compartments at the brain–meningeal border is challenging conventional
notions around molec...
www.thelancet.com
CSF transport at the brain–meningeal border: effects on neurological health and disease - The Lancet Neurology www.thelancet.com/journals/lan...
Reposted by Sandro Da Mesquita
Evidence continues building that oxidized lipids drive inflammasome activities in health and disease. A beautiful study shows a link to multiple sclerosis, with a role for inflammasomes and IL-1 in pathology. Kudos to the authors on this exciting discovery.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling - Nature Neuroscience
In this study, Yu et al. found that a positive feedback loop between oxidized phosphatidylcholine and IL-1β promotes chronic neurodegeneration in the central nervous system and could be a contributing...
www.nature.com
December 7, 2025 at 3:18 AM
Evidence continues building that oxidized lipids drive inflammasome activities in health and disease. A beautiful study shows a link to multiple sclerosis, with a role for inflammasomes and IL-1 in pathology. Kudos to the authors on this exciting discovery.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sandro Da Mesquita
Adjuvants are compounds that boost immune responses, improving the ability of vaccines to elicit long-lasting immunity against infectious diseases
go.nature.com/4a02oS3
go.nature.com/4a02oS3
Aluminium is crucial to vaccines — and safe. Why are US advisers debating it?
RFK Jr’s vaccine advisory panel will be discussing the inclusion of adjuvants in childhood vaccinations this week. Here’s what’s at stake.
go.nature.com
December 7, 2025 at 12:36 PM
Adjuvants are compounds that boost immune responses, improving the ability of vaccines to elicit long-lasting immunity against infectious diseases
go.nature.com/4a02oS3
go.nature.com/4a02oS3
Reposted by Sandro Da Mesquita
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...
#Neuroinflammation #Alzheimers
#Neuroinflammation #Alzheimers
December 2, 2025 at 5:00 PM
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...
#Neuroinflammation #Alzheimers
#Neuroinflammation #Alzheimers
The leaders of one of the most advanced countries in the world are making all the “right” decisions to turn it into a 3rd world country. Great… 🤯🤬😩
December 5, 2025 at 4:46 PM
The leaders of one of the most advanced countries in the world are making all the “right” decisions to turn it into a 3rd world country. Great… 🤯🤬😩
Ditto 👇🏻
Why we have to continue with animal testing for medical research | Letters
www.theguardian.com/science/2025...
Why we have to continue with animal testing for medical research | Letters
www.theguardian.com/science/2025...
Why we have to continue with animal testing for medical research | Letters
Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments
www.theguardian.com
December 1, 2025 at 12:19 PM
Ditto 👇🏻
Why we have to continue with animal testing for medical research | Letters
www.theguardian.com/science/2025...
Why we have to continue with animal testing for medical research | Letters
www.theguardian.com/science/2025...
Reposted by Sandro Da Mesquita
Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
@alzdemjournals.bsky.social
@alzdemjournals.bsky.social
November 28, 2025 at 6:00 PM
Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
@alzdemjournals.bsky.social
@alzdemjournals.bsky.social
Reposted by Sandro Da Mesquita
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 24, 2025 at 5:54 PM
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
Nice overview on the knowns and unknowns about pathways and mechanisms governing brain immunity and clearance. 🫶🏻😃
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 24, 2025 at 4:20 PM
Nice overview on the knowns and unknowns about pathways and mechanisms governing brain immunity and clearance. 🫶🏻😃
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
Reposted by Sandro Da Mesquita
In the least surprising news ever:
"It feels like my contribution is — just because I was not born in this country — less valued," Liu says…defunding scientific research and public health have damaged the U.S.'s reputation…top international talent are no longer interested in coming to America.”
"It feels like my contribution is — just because I was not born in this country — less valued," Liu says…defunding scientific research and public health have damaged the U.S.'s reputation…top international talent are no longer interested in coming to America.”
'Nobody wants to come': What if the U.S. can no longer attract immigrant physicians?
Immigrants make up a significant proportion of all the country's doctors. New policies are making it harder and less appealing for foreign-born physicians to come to the U.S.
www.npr.org
November 24, 2025 at 2:27 PM
In the least surprising news ever:
"It feels like my contribution is — just because I was not born in this country — less valued," Liu says…defunding scientific research and public health have damaged the U.S.'s reputation…top international talent are no longer interested in coming to America.”
"It feels like my contribution is — just because I was not born in this country — less valued," Liu says…defunding scientific research and public health have damaged the U.S.'s reputation…top international talent are no longer interested in coming to America.”
What a lovely & relaxing morning!
November 23, 2025 at 3:50 PM
What a lovely & relaxing morning!
Reposted by Sandro Da Mesquita
"In the end, I have come to realize that being authentic at work is not a weakness, but rather a strength." #ScienceWorkingLife https://scim.ag/49B7hRv
November 21, 2025 at 8:59 PM
"In the end, I have come to realize that being authentic at work is not a weakness, but rather a strength." #ScienceWorkingLife https://scim.ag/49B7hRv
Reposted by Sandro Da Mesquita
We’re hiring! Two postdoc positions are open in the Translational Neuroproteomics lab at Mayo Clinic Florida, focusing on tau and TDP-43 proteinopathies and neurodegeneration in ALS, FTD, and AD.
www.mayo.edu/research/lab...
Apply here:
1) tinyurl.com/2p9n59y5
2) tinyurl.com/em2zpu2j
Please share!
www.mayo.edu/research/lab...
Apply here:
1) tinyurl.com/2p9n59y5
2) tinyurl.com/em2zpu2j
Please share!
www.mayo.edu
November 21, 2025 at 9:27 PM
We’re hiring! Two postdoc positions are open in the Translational Neuroproteomics lab at Mayo Clinic Florida, focusing on tau and TDP-43 proteinopathies and neurodegeneration in ALS, FTD, and AD.
www.mayo.edu/research/lab...
Apply here:
1) tinyurl.com/2p9n59y5
2) tinyurl.com/em2zpu2j
Please share!
www.mayo.edu/research/lab...
Apply here:
1) tinyurl.com/2p9n59y5
2) tinyurl.com/em2zpu2j
Please share!
Reposted by Sandro Da Mesquita
Reposted by Sandro Da Mesquita
From NASA to the National Institutes of Health, federal agencies conduct research that universities cannot. Agency scientists speak with Nature about the irreplaceable facilities, institutional knowledge, and training opportunities that the country is losing. 🧪
Insiders warn how dismantling federal agencies could put science at risk
From NASA to the National Institutes of Health, federal agencies conduct research that universities cannot. Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the country is losing.
go.nature.com
November 14, 2025 at 2:21 AM
From NASA to the National Institutes of Health, federal agencies conduct research that universities cannot. Agency scientists speak with Nature about the irreplaceable facilities, institutional knowledge, and training opportunities that the country is losing. 🧪
Reposted by Sandro Da Mesquita
Just got an email from my SRO for the study section that was missed in October. Good news is that they are trying to reschedule ASAP (Dec/Jan). The bad news is that CSR is mandating that only the the top third (not half) of applications will get discussed for the next 2 rounds.
November 13, 2025 at 10:34 PM
Just got an email from my SRO for the study section that was missed in October. Good news is that they are trying to reschedule ASAP (Dec/Jan). The bad news is that CSR is mandating that only the the top third (not half) of applications will get discussed for the next 2 rounds.
“Because I Walk” 💪🏻🙂
November 9, 2025 at 8:15 PM
“Because I Walk” 💪🏻🙂
Beautiful afternoon for a “Walk to End Alzheimer’s” in Jacksonville! We @mayoclinic.org work every day to better understand this devastating neurodegenerative disease and find better treatments for patients! 🙂💪🏻🔬🧪👨🔬
@alzassociation.bsky.social
@alzassociation.bsky.social
November 9, 2025 at 7:21 PM
Beautiful afternoon for a “Walk to End Alzheimer’s” in Jacksonville! We @mayoclinic.org work every day to better understand this devastating neurodegenerative disease and find better treatments for patients! 🙂💪🏻🔬🧪👨🔬
@alzassociation.bsky.social
@alzassociation.bsky.social
RIP James Watson 😢
November 8, 2025 at 12:23 AM
RIP James Watson 😢
Reposted by Sandro Da Mesquita
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
November 5, 2025 at 11:51 PM
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
Reposted by Sandro Da Mesquita
You are not a schmuck. You cared enough about your colleagues to do everything in your power to get them a fair and thorough review. Because when the SROs return, we can only move to reschedule as quickly as we have all scores to know what will be discussed. You value your community. Thank you.
Did the reviews, like a schmuck. Only about 1/4 of the reviews were submitted. lolsob
November 3, 2025 at 7:09 PM
You are not a schmuck. You cared enough about your colleagues to do everything in your power to get them a fair and thorough review. Because when the SROs return, we can only move to reschedule as quickly as we have all scores to know what will be discussed. You value your community. Thank you.
Reposted by Sandro Da Mesquita
ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline.
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
October 30, 2025 at 3:59 PM
ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline.
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
Happy Halloween folks!
October 31, 2025 at 12:20 AM
Happy Halloween folks!
Reposted by Sandro Da Mesquita
A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Region-specific drivers of CSF mobility measured with MRI in humans - Nature Neuroscience
Brain clearance mechanisms are challenging to visualize in humans. Using magnetic resonance imaging, the authors noninvasively mapped cerebrospinal fluid motion across the brain, showing region-specif...
www.nature.com
October 24, 2025 at 4:02 PM
A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sandro Da Mesquita
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
October 22, 2025 at 6:28 PM
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Reposted by Sandro Da Mesquita
Happy to share the video Isabel Bravo-Ferrer and Katrine Gaasdal-Bech made to summarize the findings of our manuscript in Brain Communications (academic.oup.com/braincomms/a...) Age-dependent regional differences in features of the brain vasculature, including endfeet 💙!
youtu.be/mwgh_H1mcLI?...
youtu.be/mwgh_H1mcLI?...
Blood-brain barrier phenotyping shows prefrontal cortex most vulnerable to ageing in mice
YouTube video by BRAIN Journals
youtu.be
October 24, 2025 at 10:22 AM
Happy to share the video Isabel Bravo-Ferrer and Katrine Gaasdal-Bech made to summarize the findings of our manuscript in Brain Communications (academic.oup.com/braincomms/a...) Age-dependent regional differences in features of the brain vasculature, including endfeet 💙!
youtu.be/mwgh_H1mcLI?...
youtu.be/mwgh_H1mcLI?...