Thanks to the all the collaborators including the Engelman lab (DFCI/Harvard), the Aiken lab (Vanderbilt University Medical Center), the Campbell lab (Loyola University), the Hultquist lab (Northwestern University), and the Balasubramaniam lab (Meharry Medical College School of Medicine).

3/n. In infected cells, HIV-1 integration was also reduced, and this reduction was not a consequence of lower reverse transcription or nuclear entry.

Collectively, this study suggested that CPSF6-CA interaction regulates PIC function both in vitro and in infected cells.

2/n. To study CPSF6's role in HIV-1 integration, we extracted PICs from cells depleted of CPSF6 or expressing a CPSF6 mutant that cannot bind to CA. These PICs exhibited significantly lower integration activity, suggesting a direct role of CPSF6 in PIC function.

🧑‍🤝‍🧑 Social Sciences & Public Policy
Behavioral Economics
Demographic and Economic Data
Public Health Surveillance Systems