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cryoematbgu.bsky.social
CryoEM_at_BGU
@cryoematbgu.bsky.social
44 followers 23 following 2 posts
Proteins biochemistry and structural biology. Head of the cryo-EM unit at BGU
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cryoematbgu.bsky.social
WOW! I have been waiting to see this complex for MANY years!
sylviecallegari.bsky.social Sylvie Callegari @sylviecallegari.bsky.social · Mar 13
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social
March 21, 2025 at 9:22 AM
Reposted by CryoEM_at_BGU
erictopol.bsky.social
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
March 13, 2025 at 11:19 PM
Reposted by CryoEM_at_BGU
nature.com
Nature research paper: Structural dynamics of DNA unwinding by a replicative helicase

https://go.nature.com/3XWtN0b
Structural dynamics of DNA unwinding by a replicative helicase - Nature
Cryo-electron microscopy structures of DNA helicases in various conformations provide insight into an ATP-hydrolysis-dependent ‘entropy switch’ that drives unwinding of DNA for replication, with probable conservation across viral and eukaryotic systems.
go.nature.com
March 19, 2025 at 11:04 PM
cryoematbgu.bsky.social
Gotta love well-aligned beta-sheets
February 25, 2025 at 1:09 PM