Cancer Research UK Manchester Institute
@cruk-mi.bsky.social
We are a leading Cancer Research Institute within The University of Manchester, funded by Cancer Research UK (@cancerresearchuk.org)
https://www.cruk.manchester.ac.uk/
https://www.cruk.manchester.ac.uk/
🩺 HOW THIS STUDY MIGHT AFFECT RESEARCH,
PRACTICE OR POLICY
Systemic effects of long-term UVR exposure lead to systemic #immunosuppression, which impacts #melanoma & non-melanoma #CancerImmunotherapy
These findings suggest that patients may benefit
from avoiding ☀️sun exposure during #Immunotherapy
PRACTICE OR POLICY
Systemic effects of long-term UVR exposure lead to systemic #immunosuppression, which impacts #melanoma & non-melanoma #CancerImmunotherapy
These findings suggest that patients may benefit
from avoiding ☀️sun exposure during #Immunotherapy
Systemic immunosuppression from ultraviolet radiation exposure inhibits cancer immunotherapy
Background Ultraviolet radiation (UVR) affects local cutaneous and systemic immunity acutely. The wavelength, pattern and intensity of UVR exposure, individual skin phototype and immune state of indiv...
jitc.bmj.com
November 3, 2025 at 10:14 AM
🩺 HOW THIS STUDY MIGHT AFFECT RESEARCH,
PRACTICE OR POLICY
Systemic effects of long-term UVR exposure lead to systemic #immunosuppression, which impacts #melanoma & non-melanoma #CancerImmunotherapy
These findings suggest that patients may benefit
from avoiding ☀️sun exposure during #Immunotherapy
PRACTICE OR POLICY
Systemic effects of long-term UVR exposure lead to systemic #immunosuppression, which impacts #melanoma & non-melanoma #CancerImmunotherapy
These findings suggest that patients may benefit
from avoiding ☀️sun exposure during #Immunotherapy
In preliminary human data, there is an association between the molecular evidence of repeated ultraviolet radation (UVR) exposure in #dermal #fibroblasts and higher systemic #Tregs
See all the data online at:
jitc.bmj.com/content/13/1...
See all the data online at:
jitc.bmj.com/content/13/1...
November 3, 2025 at 10:14 AM
In preliminary human data, there is an association between the molecular evidence of repeated ultraviolet radation (UVR) exposure in #dermal #fibroblasts and higher systemic #Tregs
See all the data online at:
jitc.bmj.com/content/13/1...
See all the data online at:
jitc.bmj.com/content/13/1...
WHAT THIS STUDY ADDS
⇒ Authors show that systemic UVR exposure increases circulating regulatory T cells ( #Tregs ) & induces an #immunosuppressive signature within #colorectal and #melanoma mouse tumors, thereby impairing the efficacy of #immunotherapy
⇒ Authors show that systemic UVR exposure increases circulating regulatory T cells ( #Tregs ) & induces an #immunosuppressive signature within #colorectal and #melanoma mouse tumors, thereby impairing the efficacy of #immunotherapy
November 3, 2025 at 10:14 AM
WHAT THIS STUDY ADDS
⇒ Authors show that systemic UVR exposure increases circulating regulatory T cells ( #Tregs ) & induces an #immunosuppressive signature within #colorectal and #melanoma mouse tumors, thereby impairing the efficacy of #immunotherapy
⇒ Authors show that systemic UVR exposure increases circulating regulatory T cells ( #Tregs ) & induces an #immunosuppressive signature within #colorectal and #melanoma mouse tumors, thereby impairing the efficacy of #immunotherapy
🔬What is already known on this topic
⇒ #Ultraviolet radiation (UVR) alters cutaneous (in the skin) and #systemic (across the body) #immunity, but its influence on #immunotherapy outcomes in solid #cancers remains unclear
⇒ #Ultraviolet radiation (UVR) alters cutaneous (in the skin) and #systemic (across the body) #immunity, but its influence on #immunotherapy outcomes in solid #cancers remains unclear
November 3, 2025 at 10:14 AM
🔬What is already known on this topic
⇒ #Ultraviolet radiation (UVR) alters cutaneous (in the skin) and #systemic (across the body) #immunity, but its influence on #immunotherapy outcomes in solid #cancers remains unclear
⇒ #Ultraviolet radiation (UVR) alters cutaneous (in the skin) and #systemic (across the body) #immunity, but its influence on #immunotherapy outcomes in solid #cancers remains unclear
Thank you to everyone who has applied for a Group Leader position with us; this cycle of applications is now closed
November 3, 2025 at 9:33 AM
Thank you to everyone who has applied for a Group Leader position with us; this cycle of applications is now closed
Thank you to everyone who has applied for a Group Leader position with us; this cycle of applications is now closed
November 3, 2025 at 9:33 AM
Thank you to everyone who has applied for a Group Leader position with us; this cycle of applications is now closed
Thank you to everyone who has applied for a Group Leader position with us; this cycle of applications is now closed
November 3, 2025 at 9:33 AM
Thank you to everyone who has applied for a Group Leader position with us; this cycle of applications is now closed
Thank you to everyone who has applied for a Group Leader position with us; this cycle of applications is now closed
November 3, 2025 at 9:16 AM
Thank you to everyone who has applied for a Group Leader position with us; this cycle of applications is now closed