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cruk-mi.bsky.social
Cancer Research UK Manchester Institute
@cruk-mi.bsky.social
4.4K followers 2.5K following 220 posts
We are a leading Cancer Research Institute within The University of Manchester, funded by Cancer Research UK (@cancerresearchuk.org)

https://www.cruk.manchester.ac.uk/
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cruk-mi.bsky.social
Looking for a new job?

We're currently recruiting to research, technical and operations roles

See all details of these opportunities on our #Careers pages: www.cruk.manchester.ac.uk/careers/
Graphic shows researchers working in a laboratory, along with titles of the jobs listed on our website at the moment
November 7, 2025 at 3:18 PM
cruk-mi.bsky.social
Our Institute Director, Professor Samra Turajlić, will be giving a public talk at @crick.ac.uk

💬Crick Crash Course: Immunotherapy
📅Wed 19th Nov
🕙10am
📌Crick Institute, London

For full details and to book: www.eventbrite.co.uk/e/crick-cras...

@turajliclab.bsky.social #Immunotherapy
Graphic advertising the Immunotherapy Crash Course, with a photograph of Prof Turajlić, a QR code for booking and the details of the event (as in the main text of the message) along with a background image of cells and tissues
November 4, 2025 at 11:54 AM
cruk-mi.bsky.social
In preliminary human data, there is an association between the molecular evidence of repeated ultraviolet radation (UVR) exposure in #dermal #fibroblasts and higher systemic #Tregs

See all the data online at:
jitc.bmj.com/content/13/1...
(C) Cartoon showing experimental approach for classifying UVR signature in GTEx patient cohort. (D) Tregs score from the peripheral blood of non-UVR (n=143) and UVR (n=142) GTEx patients, Mann-Whitney one-tailed test. GTEx, Genotype-Tissue Expression; MHC, major histocompatibility complex; NES, normalized enrichment score; PD-1, programmed cell death protein-1; RNA-seq, RNA sequencing; Treg, regulatory T cells; UVR, ultraviolet radiation.
November 3, 2025 at 10:14 AM
cruk-mi.bsky.social
WHAT THIS STUDY ADDS

⇒ Authors show that systemic UVR exposure increases circulating regulatory T cells ( #Tregs ) & induces an #immunosuppressive signature within #colorectal and #melanoma mouse tumors, thereby impairing the efficacy of #immunotherapy
Figure 1 Chronic UVR exposure impacts peripheral immunity - panel L - CD4+FOXP3+ cells in CD3+ gate,All immune populations determined by flow cytometry in the peripheral blood of UVR mice (n=20) exposed to 6 weeks of UVR and non-UVR (n=19) matched controls.
November 3, 2025 at 10:14 AM
cruk-mi.bsky.social
🔬What is already known on this topic

⇒ #Ultraviolet radiation (UVR) alters cutaneous (in the skin) and #systemic (across the body) #immunity, but its influence on #immunotherapy outcomes in solid #cancers remains unclear
Screenshot of key points from the front page of the PDF version of the paper: What is already known on this topic Ultraviolet radiation (UVR) alters cutaneous and systemic immunity, but its influence on immunotherapy outcomes in solid cancers remains unclear. What this study adds We show that systemic UVR exposure increases circulating regulatory T cells (Tregs) and induces an immunosuppressive signature within colorectal and melanoma mouse tumors, thereby impairing the efficacy of immunotherapy. Humans with cutaneous molecular hallmarks of UVR exposure have higher circulatory Tregs. How this study might affect research, practice or policy These findings suggest that patients may benefit from avoiding sun exposure during immunotherapy.
November 3, 2025 at 10:14 AM
cruk-mi.bsky.social
You've got just a few days left to submit your proposal to join us as a new Group Leader

📅 Applications close 2nd November

Package includes:

🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship

Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
October 30, 2025 at 11:47 AM
cruk-mi.bsky.social
Exciting #postdoc opportunity to join @turajliclab.bsky.social here in #Manchester (with visiting scientist status @crick.ac.uk) to use novel tools to investigate #aneuploidy in #KidneyCancer

For full details of the position, including how to apply, visit:

www.cruk.manchester.ac.uk/career/mi-25...
Image background shows An immunofluorescence microscopy image of kidney tissue showing different tissue structures stained in red, blue, and green. The overlapping colours in some regions suggest the complex structure and the close association of these different cell types within the kidney. Text reads: We are hiring: Postdoctoral Scientist Department: Cancer Dynamics Salary: £37,000 - £44,852 pa (dependent upon qualifications and experience) Job ID: MI/25/56 Apply by 23rd November 2025
October 24, 2025 at 11:33 AM
cruk-mi.bsky.social
Just 3 days left to apply for a #postdoc position with @clausjorgensen.bsky.social and the Systems Oncology group

🥼Study a novel therapeutic target in #PancreaticCancer relating to the #TumourMicroenvironment

For full details & to apply please visit: www.cruk.manchester.ac.uk/career/mi-25...
Image shows graphics of calendars and clocks, text reads 3 days to go - time is running out - apply for this role today! MI/25/33_2 Postdoctoral Scientist Systems Oncology Group Apply by 26th October
October 23, 2025 at 3:49 PM
cruk-mi.bsky.social
We're big on #TeamScience and currently recruiting to a number of key roles to support our #CancerResearch work here in #Manchester

Technologist, Communicator, Postdoc, PI - which role could you see yourself in?

Full details of each role on our #Careers pages:
www.cruk.manchester.ac.uk/careers/
Image in style of Tinker, Tailor, Soldier, Spy book cover Background shows a lab coat tinted yellow on a film-grain background of muted greys and browns. Text says "Technologist, Communicator, Postdoc, PI" and "For full details of all current opportunities please visit our website cruk.manchester.ac.uk/careers"
October 20, 2025 at 11:29 AM
cruk-mi.bsky.social
We are excited to announce that our #PhD Student Recruitment is open for applications!

For full details of all projects and information on how to apply, visit: www.cruk.manchester.ac.uk/phd-student-...

📅 Applications close 28th November & we look forward to hearing from you!
October 17, 2025 at 10:02 AM
cruk-mi.bsky.social
Interested in establishing your own research group?
Our support package for new Group Leaders includes:

🥼2 #Postdocs, a technician & 2 PhD students + lab costs
🔬Full access to core facilities
🧪Access to the MCRC #Biobank
✔️Mentorship, #grant advice & more

www.cruk.manchester.ac.uk/career/new-g...
Graphic has a blue-tone photograph of the Paterson Building on the right-hand side, with a dark blue background and white text on the left Text says: We Are Recruiting New Group Leaders Join us in Manchester / Develop bold, innovative, & high-impact research programmes Salary £58,000 – £65,000 (dependent upon experience/clinical work) Job ID MI/25/54 Apply by 2nd November 2025
October 8, 2025 at 10:52 AM
cruk-mi.bsky.social
We are recruiting!

Visit www.cruk.manchester.ac.uk/careers/ for full details of all current vacancies, including:

🥼New Group Leaders [Apply by 2nd November]

🧪Postdoctoral Researchers with @sylvaindelaunay.bsky.social & @clausjorgensen.bsky.social

⚛️ #MassSpectrometry Technologist

More below 👇
Image shows three glowing bottles of liquid in a scientific machine, with a fourth empty space between the bottles Text says "Find your place at the Cancer Research UK Manchester Institute" and visit https://www.cruk.manchester.ac.uk/careers/
October 3, 2025 at 2:17 PM
cruk-mi.bsky.social
This #NationalPostdocAppreciationWeek, our Director Prof Samra Turajlić (@turajliclab.bsky.social) shared her thoughts:

"Our postdoctoral researchers play a vital role in advancing our research mission - driving innovation, mentoring students, and contributing to a positive research culture.

1/3
Graphic of part of the quote from Professor Samra Turajlić, Director of the Cancer Research UK Manchester Institute (shown in a small inset icon) Text says: "National Postdoc Appreciation Week Our postdoctoral researchers play a vital role in advancing our research mission - driving innovation, mentoring students, and contributing to a positive research culture. #LovePostdocs" Dark lettering on a pale blue background with abstract swirls and CRUK Manchester Institute logo
September 19, 2025 at 3:44 PM
cruk-mi.bsky.social
Today we are delighted to welcome Professor Samra Turajlić (@turajliclab.bsky.social) as our new Institute Director!

Her work - spanning basic, translational & cancer research - has advanced our understanding of cancer biology & treatment

Read more here: www.cruk.manchester.ac.uk/news/profess...
A photograph of Professor Samra Turajlić in the Paterson Building, standing next to the door of her new office which is slightly ajar and has the name plate "CRUK MI Director"
September 1, 2025 at 2:41 PM
cruk-mi.bsky.social
@nataliamoncaut.bsky.social, head of our Genome Editing and Mouse Models Core Facility, is co-organising a workshop on #GenomeEditing supported by @mrcmousenetwork.bsky.social and @crick.ac.uk 🧬🧪🥼

Places are limited, so use this link to apply by 30th September:

www.crick.ac.uk/whats-on/uk-...
Quote image shows a photograph of Natalia Moncaut, and quote in blue text says: "I'm excited to be one of the organisers of an interactive Genome Engineering Technologies workshop this November, supported by the MRC National Mouse Genetics Network and the Francis Crick Institute. We’re bringing together UK experts in cell line, organoid, and mouse genome engineering to share insights and tackle shared challenges. The event is free to attend, but places are limited - so don’t delay!"
August 29, 2025 at 3:03 PM
cruk-mi.bsky.social
This prestigious fellowship is awarded in memory of Professor Amit Patel, Consultant Haematologist at The Christie, who sadly passed away in 2021.

His outstanding legacy is recognised through this fellowship, generously funded through The Christie Charity’s 2030 research programme.
A photograph of Prof Amit Patel, Consultant Haematologist at The Christie, who sadly passed away in 2021.
August 28, 2025 at 1:31 PM
cruk-mi.bsky.social
We are delighted to announce, along with The Christie NHS Foundation Trust, the appointment of Dr Justin Loke - @jloke1.bsky.social - to the Amit Patel Leukaemia Research Fellowship, bringing his expertise in haematological research & #AML to our Institute

www.cruk.manchester.ac.uk/news/justin-...
Image shows a photograph of Dr Justin Loke, along with a quote: "“I am delighted and privileged to join Manchester with experience of new technologies and scientific training from the Dana-Farber Cancer Institute.”
August 28, 2025 at 1:31 PM
cruk-mi.bsky.social
We are recruiting to a variety of roles, check out our Careers pages for all the details of research and operations positions including:

🥼 Scientific Officer
💻Computational Immunologist
🧪 Laboratory Aide
📝 Executive Assistant

www.cruk.manchester.ac.uk/careers/

Join us to advance #Cancer Research
An image of three brightly lit, glowing green bottles with an empty space for a fourth bottle, as part of a flow cytometry machine Text says "New Job openings - See all recruitment opportunities by visiting https://www.cruk.manchester.ac.uk/careers/"
August 15, 2025 at 4:37 PM
cruk-mi.bsky.social
Today we welcomed the Lambros to the Paterson Building - two Aussie brothers running the entire UK in support of @cancerresearchuk.org

Their fundraising page has info on all their marathons - even in the 30+ degree heat of #Manchester!

givestar.io/gs/lambros--...

#OncoSky #CanSky #CancerResearch
Photograph of the two Lambros brothers wearing lab coats and standing in one of the labs in the Paterson Building Text says: "Lambros visit the Paterson Building" and "Running the UK to raise money for Cancer Research" Icons show runners, a map of the UK, coins and the Cancer Research UK logo
August 13, 2025 at 2:21 PM
cruk-mi.bsky.social
We are recruiting!

🥼 Scientific Officer to work with @drwilliamhill.bsky.social
💻 Computational Immunologist in the lab of @santiagozelenay.bsky.social
📝 Executive Assistant to our new Institute Director Prof Samra Turajlić @turajliclab.bsky.social

Details at:
www.cruk.manchester.ac.uk/careers/
Photograph shows three researchers in Cancer Research UK lab coats looking at a folder of documents in a laboratory in the Paterson Building Text says: Join our Team - We're currently recruiting both research and operations positions Scientific Officer - MI/25/32 Computational Immunologist - MI/25/17_2 Executive Assistant to Institute Director - MI/25/44
August 8, 2025 at 12:36 PM
cruk-mi.bsky.social
We are hiring an #ExecutiveAssistant to support our new Institute Director, Prof Samra Turajlić

Apply online today at: apps.cruk.manchester.ac.uk/recruitment/...

Starting Salary: Circa £40,000 per annum
Closing Date: 28/08/2025
Duration of Post: Permanent
Job Ref: MI/25/44
August 4, 2025 at 12:32 PM
cruk-mi.bsky.social
Dr Amaya Viros, head of our Skin Cancer and Ageing Group, has spoken to @telegraphnews.bsky.social for an interview covering her research on #melanoma and #metastasis, and #PersonalisedMedicine

See our website for a full write up and link to the article: www.cruk.manchester.ac.uk/news/dr-amay...
Graphic shows a laptop computer on a table with a coffee cup and mobile phone alongside On the screen is an image from the Telegraph website entitled "Working towards a skin cancer-free future" with an illustration of a doctor attending a patient with suspected skin cancer
July 23, 2025 at 10:19 AM
cruk-mi.bsky.social
🌟We congratulate Dr Evangelos Giampazolias - @giampazolias.bsky.social - on winning the @thebacr.bsky.social / @astra-zeneca.bsky.social Young Scientist Frank Rose Award 2025 🌟

Visit our website for full details of the award & interview with Evangelos: www.cruk.manchester.ac.uk/staff-news/p...
Graphic shows a photograph of Dr Evangelos Giampazolias, on a dark blue background with light grey circles Text says "Congratulations on your award" and shows the Cancer Research UK Manchester Institute logo
July 21, 2025 at 2:11 PM
cruk-mi.bsky.social
🚨 New Blog Post 🚨
@luisa86ferreira.bsky.social was one of 5 Conference Correspondents for @helloeacr.bsky.social at #EACR2025

She shares her reflections from the conference & spotted some familiar #Manchester #CancerResearch faces amongst the attendees 👇

www.cruk.manchester.ac.uk/news/researc...
EACR Conference attendees gathering in the main hall at the event - photo taken from the balcony showing the many people attending
July 4, 2025 at 3:26 PM
cruk-mi.bsky.social
Julie Edwards, our Postgraduate Programme Manager (www.cruk.manchester.ac.uk/students/) said:

"Absolutely fantastic job organising the IPSCC this year - a huge team effort over the last 12 months and you should all be extremely proud of its great success!"

#IPSCC #StudentConference
Photograph shows the whole organising committee outside in front of a large mosaic mural
July 2, 2025 at 9:11 AM