Congratulations!

Neat Elphege. Look forward to seeing the data play out and if there are curious functional differences for any chromatin modification in post-mitotic vs. dividing cell states

My pleasure

LPS-stimulated macrophages
pmc.ncbi.nlm.nih.gov/articles/PMC...

Neural maturation in vivo and pharmacologically stimulated post-mitotic neurons in vitro
elifesciences.org/articles/76539

human post-mitotic neurons
www.biorxiv.org/content/10.1...

as they say: Mo' Loops, Mo' Problems

-Critical developmentally regulated enhancer-promoter loops
-Establishment of new gene expression, not maintenance
-Genes with multiple distant enhancers
-In physiologic or developmentally relevant models
-Strong perturbations and rigorous technology
-Disruption linked to severe disease phenotypes

It has been unambiguously demonstrated that loops are necessary for the establishment of new induced gene expression programs in post-mitotic neurons in vitro and in vivo and in macrophages in vitro. Clean, strong perturbations in physiolgically or developmentally relevant models helped resolve.

It's profound how the OP insight scales to life in science too.
The scientists that find that absolutely most amazing creative unexpected patterns in data that are actually true and stand the test of time tend to obsess about every minor detail and dot every i and cross every t.

It's beyond hard right now - profound disappointment in the system. Yet - science and the power of the scientific method to seek truth is timeless. Truth always comes into the light in the end. Your skills and all you've trained to learn will matter more than ever in the coming years.

100% in your corner and in the corner of your very bright future no matter what comes next

aortae

awesome family - and Oracle from the inside 🤩