#keepNIHstrong

Research is a virtuous cycle that brings hope to those hurting.

Researchers and physicians are front line warriors for the greatest medical problems of our time.

Research fuels engines of innovation and drives economic growth.

www.unitedformedicalresearch.org/annual-econo...

we celebrated him and 25 years of his impact on all of us in June - you can see the trigger words if you look closely at his garish blue slides from the roast

Thank you to many wonderful colleagues who invested in our community and allowed all voices to be valued and heard. Our perspective mattered, we belonged, and it made the difference for the quality and impact of the science.

Tangible excitement for the future - the best is yet to come.

Onward.

Congratulations to our alum Dr. Ji Hun Kim who has started his own laboratory at KAIST and just won his first independent grant. Ji Hun is the co-inventor of LADL and will build out the technology to understand condensates in disease.
pubmed.ncbi.nlm.nih.gov/31235883/

Ten years.

Together we built a warm, tight-knit, international community, shared new computational and experimental technologies around the the world, posted >400 preprints, and catalyzed understanding of the mechanisms and functions of chromatin in development and disease.

Outstanding talks from the next generation of chromatin researchers - excited for the future
@gracebower.bsky.social of @evgenykvon.bsky.social lab
@sedonamurphy.bsky.social of Yale Cell Bio
Tessa Pompay of Dixon lab
Zoe Grant of @benoitbruneau.bsky.social lab
Quan Zhu of Shen & Ren labs
& others

Congratulations to PhD student Rohan Patel @rohaniopatel.bsky.social: Awarded a new NIH F31 fellowship for his work to computationally explore chromatin patterns and mechanisms of loop extrusion in sequential oligopaints imaging data. doi.org/10.1101/2024...
x.com/PatelRohanD/...

@krtitus.bsky.social observed that promoter-enhancer loops strongly correlate with RNAPol2 elongation and not initiation in human neuron differentiation. Disruption of elongation perturbs loops. Working model: elongation re-inforces and maintains P-E loops
10.1016/j.xgen.2024.100606

Dr. Chandrashekar is a strong computational biologist with a knack for rigorous work to seek out biologically relevant patterns for hypothesis-driven followup experiments. Here with our team at her PhD defense - and now on the job market

At X: x.com/HarshiniChan...

Harshini linked motifs for the DLX&LHX2 homeodomain TFs to the miswiring of genome structure-function prior to the detection of amyloid plaques and tau tangles - consistent with work from @evgenykvon.bsky.social
- uncovering a potentially new genome folding mechanism

Congratulations Dr. Chandrashekar 💐
Using human neurons homozygously-engineered with familial AD mutations, Harshini found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs

doi.org/10.1101/2024...