Cravedi Lab
@cravedilab.bsky.social
Kidney & Immunology Research at Icahn School of Medicine at Mount Sinai
Reposted by Cravedi Lab
New method could improve manufacturing of gene-therapy drugs.
#science #news
www.lifescience.net/news/6673/ne...
#science #news
www.lifescience.net/news/6673/ne...
New method could improve manufacturing of gene-therapy drugs
Selective crystallization can greatly improve the purity, selectivity, and active yield of viral vector-based gene therapy drugs, study finds.
www.lifescience.net
November 7, 2025 at 9:12 PM
New method could improve manufacturing of gene-therapy drugs.
#science #news
www.lifescience.net/news/6673/ne...
#science #news
www.lifescience.net/news/6673/ne...
Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes url: jamanetwork.com/journals/jam...
Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes
This meta-analysis evaluates the prevalence and characteristics of discordance between creatinine- and cystatin C–based estimated glomerular filtration rate as well as the association of discordance w...
jamanetwork.com
November 7, 2025 at 9:06 PM
Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes url: jamanetwork.com/journals/jam...
JCI - GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity www.jci.org/articles/vie...
JCI -
GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity
www.jci.org
November 5, 2025 at 7:56 PM
JCI - GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity www.jci.org/articles/vie...
Drug repurposing in PIK3CA-related overgrowth spectrum: breakthroughs from overgrowth syndromes to kidney disease - Kidney International www.kidney-international.org/article/S008...
Drug repurposing in PIK3CA-related overgrowth spectrum: breakthroughs from overgrowth syndromes to kidney disease
PI3Kα is a ubiquitous lipid kinase that transduces extracellular growth, proliferation
and metabolism signals. Genes involved in the PI3Kα signaling pathway are frequently
mutated in cancer. Apart fro...
www.kidney-international.org
November 2, 2025 at 5:42 PM
Drug repurposing in PIK3CA-related overgrowth spectrum: breakthroughs from overgrowth syndromes to kidney disease - Kidney International www.kidney-international.org/article/S008...
Reposted by Cravedi Lab
PARASOL Project is expanding focus to include biomarkers & endpoints in APOL1 kidney disease and primary MN as well as FSGS. Learn more: eu1.hubs.ly/H0nr8Lv0
@tobias-b-huber.bsky.social @miktmc.bsky.social @jarcyzphd.bsky.social @ohiostatemed.bsky.social @utoronto.ca @nu-nephrology.bsky.social
@tobias-b-huber.bsky.social @miktmc.bsky.social @jarcyzphd.bsky.social @ohiostatemed.bsky.social @utoronto.ca @nu-nephrology.bsky.social
PARASOL Project Expands Focus to APOL1, Membranous Nephropathy
PARASOL Project expands to focus on APOL1 kidney disease and primary membranous nephropathy, aiming to improve clinical trial endpoints for these conditions.
eu1.hubs.ly
October 3, 2025 at 1:35 PM
Subzero Kidney Preservation Comes to Scale - American Journal of Transplantation www.amjtransplant.org/article/S160...
Subzero Kidney Preservation Comes to Scale
Since the 1980s, static cold storage (SCS), and its close cousin hypothermic perfusion,
have been the standard preservation methods for kidney grafts. Nevertheless, hypothermic
temperatures (4 to 0°C)...
www.amjtransplant.org
October 31, 2025 at 1:19 PM
Subzero Kidney Preservation Comes to Scale - American Journal of Transplantation www.amjtransplant.org/article/S160...
Daratumumab Efficacy in Steroid-Resistant Nephrotic Syndrome Correlates with CD38+ B-Cell Depletion
www.kireports.org/article/S246...
www.kireports.org/article/S246...
Daratumumab Efficacy in Steroid-Resistant Nephrotic Syndrome Correlates with CD38+ B-Cell Depletion
The anti-CD38 monoclonal antibody daratumumab, alone or with anti-CD20 rituximab,
can induce remission in steroid-resistant nephrotic syndrome or multidrug-dependent
nephrotic syndrome.1 However, the ...
www.kireports.org
October 27, 2025 at 10:52 PM
Daratumumab Efficacy in Steroid-Resistant Nephrotic Syndrome Correlates with CD38+ B-Cell Depletion
www.kireports.org/article/S246...
www.kireports.org/article/S246...
Mucin O-glycosylation and B cell homing: a new bridge for the gut-kidney axis in IgA nephropathy?
www.kidney-international.org/article/S008...
www.kidney-international.org/article/S008...
Mucin O-glycosylation and B cell homing: a new bridge for the gut-kidney axis in IgA nephropathy?
IgA nephropathy (IgAN) is an insidious autoimmune glomerulonephritis that often progresses
to end-stage kidney failure, despite anti-inflammatory and anti-proteinuric therapies1.
An evolving understan...
www.kidney-international.org
October 26, 2025 at 5:45 PM
Mucin O-glycosylation and B cell homing: a new bridge for the gut-kidney axis in IgA nephropathy?
www.kidney-international.org/article/S008...
www.kidney-international.org/article/S008...
Iohexol clearance, but not estimated GFR, reveals a steeper GFR decline in patients with prediabetes
www.kidney-international.org/article/S008...
www.kidney-international.org/article/S008...
Iohexol clearance, but not estimated GFR, reveals a steeper GFR decline in patients with prediabetes
Prediabetes, an intermediate state between normoglycemia and type 2 diabetes affecting
720 million individuals worldwide, is associated with hyperfiltration, an early stage
of diabetic kidney disease....
www.kidney-international.org
October 26, 2025 at 5:44 PM
Iohexol clearance, but not estimated GFR, reveals a steeper GFR decline in patients with prediabetes
www.kidney-international.org/article/S008...
www.kidney-international.org/article/S008...
Proinflammatory and cytotoxic CD38+HLA-DR+ effector memory CD8+ T cells are peripherally expanded in human cardiac allograft vasculopathy
www.amjtransplant.org/article/S160...
www.amjtransplant.org/article/S160...
Proinflammatory and cytotoxic CD38+HLA-DR+ effector memory CD8+ T cells are peripherally expanded in human cardiac allograft vasculopathy
Interferon-γ (IFNG) is thought to play a central role in the pathogenesis of cardiac
allograft vasculopathy (CAV) in heart transplant (HTx) patients. However, peripheral
lymphocytes participating in t...
www.amjtransplant.org
October 26, 2025 at 5:40 PM
Proinflammatory and cytotoxic CD38+HLA-DR+ effector memory CD8+ T cells are peripherally expanded in human cardiac allograft vasculopathy
www.amjtransplant.org/article/S160...
www.amjtransplant.org/article/S160...
Educational Strategies to Prepare Trainees for Clinical Uncertainty | New England Journal of Medicine www.nejm.org/doi/full/10....
Educational Strategies to Prepare Trainees for Clinical Uncertainty | NEJM
Uncertainty is ubiquitous in the practice of medicine. This review characterizes clinical
uncertainty and shows how teachers can guide learners to recognize, manage, and communicate
uncertainty in ...
www.nejm.org
October 26, 2025 at 5:39 PM
Educational Strategies to Prepare Trainees for Clinical Uncertainty | New England Journal of Medicine www.nejm.org/doi/full/10....
Reposted by Cravedi Lab
Part of our virtual special issue, Best Practices for Mouse Models of Organ Transplantation:
Check out the article, "Best Practices in Mouse Models of Skin Transplantation" by Borges et al. Online & in press!
www.amjtransplant.org/article/S160...
Check out the article, "Best Practices in Mouse Models of Skin Transplantation" by Borges et al. Online & in press!
www.amjtransplant.org/article/S160...
October 24, 2025 at 12:15 PM
Part of our virtual special issue, Best Practices for Mouse Models of Organ Transplantation:
Check out the article, "Best Practices in Mouse Models of Skin Transplantation" by Borges et al. Online & in press!
www.amjtransplant.org/article/S160...
Check out the article, "Best Practices in Mouse Models of Skin Transplantation" by Borges et al. Online & in press!
www.amjtransplant.org/article/S160...
A new chapter in the EPO Saga!
Erythropoietin prolongs graft survival in mice by counteracting trained immunity - American Journal of Transplantation www.amjtransplant.org/article/S160...
Erythropoietin prolongs graft survival in mice by counteracting trained immunity - American Journal of Transplantation www.amjtransplant.org/article/S160...
Erythropoietin prolongs graft survival in mice by counteracting trained immunity
Upon activation, macrophages undergo epigenetic and metabolic reprogramming, resulting
in stronger responses to subsequent insults (trained immunity), and, in the case of
transplant, in accelerated re...
www.amjtransplant.org
October 22, 2025 at 5:39 PM
A new chapter in the EPO Saga!
Erythropoietin prolongs graft survival in mice by counteracting trained immunity - American Journal of Transplantation www.amjtransplant.org/article/S160...
Erythropoietin prolongs graft survival in mice by counteracting trained immunity - American Journal of Transplantation www.amjtransplant.org/article/S160...
Reposted by Cravedi Lab
Very good 😂. This describes a lot of what is going on accurately.
Credit: @integralanswers.bsky.social
Credit: @integralanswers.bsky.social
October 18, 2025 at 1:30 PM
Very good 😂. This describes a lot of what is going on accurately.
Credit: @integralanswers.bsky.social
Credit: @integralanswers.bsky.social
Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors: Cell Reports Medicine www.cell.com/cell-reports...
Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors
Niu et al. construct the circCV-B3 vector to enable scarless circRNA engineering.
Utilizing circCV-B3 vector, they engineer circILNb for co-encoding IL-15 and anti-PD-L1
nanobody. Additionally, they d...
www.cell.com
October 17, 2025 at 8:18 AM
Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors: Cell Reports Medicine www.cell.com/cell-reports...
The fading darling: Patient voice as the future of transplant trust
www.amjtransplant.org/article/S160...
www.amjtransplant.org/article/S160...
The fading darling: Patient voice as the future of transplant trust
Organ transplantation saves tens of thousands of lives annually. As a renal recipient,
I am counted among those many miracles. Unfortunately, the field is quickly slipping
from its position as the dar...
www.amjtransplant.org
October 16, 2025 at 11:39 PM
The fading darling: Patient voice as the future of transplant trust
www.amjtransplant.org/article/S160...
www.amjtransplant.org/article/S160...
Sildenafil Modulates Dendritic Cell Motility as a New Immunomodulatory Strategy
www.amjtransplant.org/article/S160...
www.amjtransplant.org/article/S160...
Sildenafil Modulates Dendritic Cell Motility as a New Immunomodulatory Strategy
Targeting dendritic-cell motility via the PDE5–cGMP axis offers a new path to modulate
tumor and potentially transplant immunity.
www.amjtransplant.org
October 16, 2025 at 11:37 PM
Sildenafil Modulates Dendritic Cell Motility as a New Immunomodulatory Strategy
www.amjtransplant.org/article/S160...
www.amjtransplant.org/article/S160...
Epigenetically modulating macrophage subpopulations to promote long-term allograft survival in a mouse heart transplant model - American Journal of Transplantation www.amjtransplant.org/article/S160...
Epigenetically modulating macrophage subpopulations to promote long-term allograft survival in a mouse heart transplant model
Despite much-improved protocols that broadly suppress the adaptive immune cells, most
allografts are still lost to chronic rejection, in which macrophages have been prominently
featured in the graft. ...
www.amjtransplant.org
October 10, 2025 at 6:25 PM
Epigenetically modulating macrophage subpopulations to promote long-term allograft survival in a mouse heart transplant model - American Journal of Transplantation www.amjtransplant.org/article/S160...
Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy - Kidney International www.kidney-international.org/article/S008...
Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy
Membranoproliferative glomerulonephritis (MPGN) is currently stratified into complement
C3 glomerulopathy (C3G) and immune complex-mediated MPGN (IC-MPGN). However, classification
is subject to contin...
www.kidney-international.org
October 9, 2025 at 11:41 PM
Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy - Kidney International www.kidney-international.org/article/S008...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
www.science.org
October 9, 2025 at 6:18 PM
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...
How Propensity Scores Work | NEJM Evidence evidence.nejm.org/doi/full/10....
How Propensity Scores Work
This Stats, STAT! animated video explores the use of propensity scores — a method
of controlling for observed confounders in non-randomized studies.
evidence.nejm.org
October 9, 2025 at 2:38 AM
How Propensity Scores Work | NEJM Evidence evidence.nejm.org/doi/full/10....