@cpherlihy.bsky.social
Postdoctoral Fellow in the Department of Genome Sciences at the University Washington
Reposted
The definitive obituary of James Watson, written by the late, great Sharon Begley @statnews.com www.statnews.com/2025/11/07/j...
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 10, 2025 at 5:51 PM
The definitive obituary of James Watson, written by the late, great Sharon Begley @statnews.com www.statnews.com/2025/11/07/j...
Reposted
Fantastic project led by @bo-wen.bsky.social. Excited to see the future uses of AI and transfer learning in proteomics. #massspec #proteomics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Carafe enables high quality in silico spectral library generation for data-independent acquisition proteomics - Nature Communications
Accurate spectral libraries are essential for analyzing data-independent acquisition (DIA) proteomics data. Here, the authors present Carafe, which trains on DIA data to build experiment-specific spec...
www.nature.com
November 6, 2025 at 3:49 PM
Fantastic project led by @bo-wen.bsky.social. Excited to see the future uses of AI and transfer learning in proteomics. #massspec #proteomics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
November 5, 2025 at 11:09 PM
Reposted
NEW: After paying for hotel rooms to shelter homeless people, Seattle deliberately left them vacant.
By the end of 2024, taxpayers were spending $4,200 a month per empty room at a time when thousands of residents were without a roof over their heads.
By the end of 2024, taxpayers were spending $4,200 a month per empty room at a time when thousands of residents were without a roof over their heads.
Seattle Spent Millions on Hotel Rooms to Shelter Unhoused People. Then It Stopped Filling Them.
Early last year, the city signed a $2.7 million lease extension to continue using a hotel’s rooms as shelter space. Yet despite committing to pay the rent, the city stopped sending people there.
www.propublica.org
October 6, 2025 at 12:00 PM
NEW: After paying for hotel rooms to shelter homeless people, Seattle deliberately left them vacant.
By the end of 2024, taxpayers were spending $4,200 a month per empty room at a time when thousands of residents were without a roof over their heads.
By the end of 2024, taxpayers were spending $4,200 a month per empty room at a time when thousands of residents were without a roof over their heads.
Reposted
Note that the Trump Administration is already going back to schools with whom it earlier reached "deals" (such as UPenn and Brown) for further concessions. Conceding to a bully has only emboldened them to make new demands.
October 2, 2025 at 10:44 AM
Note that the Trump Administration is already going back to schools with whom it earlier reached "deals" (such as UPenn and Brown) for further concessions. Conceding to a bully has only emboldened them to make new demands.
Reposted
The New York Yankees beat the Boston Red Sox in Wild Card Series to advance to the AL Division Series against the Toronto Blue Jays.
Schlittler strikes out 12 in postseason debut as Yankees beat Red Sox 4-0 to win Wild Card Series
Rookie right-hander Cam Schlittler struck out 12 as he shut down Boston with 100 mph heat, and the New York Yankees took advantage of a pair misplays in a four-run fourth inning to beat the Red Sox 4-0 for a 2-1 AL Wild Card Series win and a Division Series matchup against Toronto.
bit.ly
October 3, 2025 at 3:03 AM
The New York Yankees beat the Boston Red Sox in Wild Card Series to advance to the AL Division Series against the Toronto Blue Jays.
Reposted
New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...
September 26, 2025 at 6:06 PM
New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...
Reposted
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse
YouTube video by Stowers Institute for Medical Research
youtu.be
September 24, 2025 at 6:48 PM
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
Reposted
Elite colleges are infamous for funneling students into the Big Three—consulting, tech, and finance—high-paying fields that perpetuate status and wealth.
To some young people, it feels like entrapment: “They get you before you could be exposed to other jobs.”
To some young people, it feels like entrapment: “They get you before you could be exposed to other jobs.”
America’s elite colleges are perpetual inequality machines. It doesn't have to be this way.
Rather than steer the nation's top students toward the most lucrative careers, schools could help them build meaningful lives.
www.motherjones.com
September 24, 2025 at 2:45 PM
Elite colleges are infamous for funneling students into the Big Three—consulting, tech, and finance—high-paying fields that perpetuate status and wealth.
To some young people, it feels like entrapment: “They get you before you could be exposed to other jobs.”
To some young people, it feels like entrapment: “They get you before you could be exposed to other jobs.”
Reposted
Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers
DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...
www.biorxiv.org
September 20, 2025 at 4:10 PM
Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
Reposted
Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.
A Trailblazing Geneticist Reflects On Her Life And Work
Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.
buff.ly
September 19, 2025 at 6:12 PM
Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.
Reposted
Real-time API control of mass specs has been hard to get started (C#, VS, etc). Mike Hoopmann's recent work makes dev easier & more open!:
Nova - lightweight dev library
schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10....
Helios - a unified instrument API now @ JPR
github.com/SchweppeLab/...
Nova - lightweight dev library
schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10....
Helios - a unified instrument API now @ JPR
github.com/SchweppeLab/...
September 8, 2025 at 11:05 PM
Real-time API control of mass specs has been hard to get started (C#, VS, etc). Mike Hoopmann's recent work makes dev easier & more open!:
Nova - lightweight dev library
schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10....
Helios - a unified instrument API now @ JPR
github.com/SchweppeLab/...
Nova - lightweight dev library
schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10....
Helios - a unified instrument API now @ JPR
github.com/SchweppeLab/...
Reposted
Reposted
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
August 13, 2025 at 2:19 PM
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵