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Reposted by Cristian Pattaro

Triad sou. @triadsou.bsky.social · 16h

On “Confirmatory” Methodological Research in Statistics and Related Fields. F. J. D. Lange, Juliane C. Wilcke, Sabine Hoffmann, Moritz Herrmann, Anne-Laure Boulesteix. Statistics in Medicine. onlinelibrary.wiley.com/doi/10.1002/...

On “Confirmatory” Methodological Research in Statistics and Related Fields

Empirical substantive research, such as in the life or social sciences, is commonly categorized into the two modes exploratory and confirmatory, both of which are essential to scientific progress. Th...

onlinelibrary.wiley.com

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Edgar V. Lerma 🇵🇭 @edgarvlermamd.bsky.social · 4d

Is It Time to Consider Population-Based Urine Dipstick Screening for Early Detection of Kidney Disease? ca. 2025 from @kireports.bsky.social @saynanorouzi.bsky.social
#Nephpearls #KidneyWk #NephSky

👉 www.kireports.org/article/S246...

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AldoLabZennaro @aldolabz.bsky.social · 13d

I am deeply honored to have been awarded the European Hormone Medal 2026!

European Society of Endocrinology @esendocrinology.bsky.social · 13d

We are delighted to announce the winners of the ESE Awards for 2026.🏆

🎉Congratulations to our exceptional winners who have made huge contributions in the field of #endocrinology and will present at #ECE2026 in Prague, Czech Republic from 9-12 May 2026.

Find out more👉 ow.ly/ITyL50XjEWm

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Cristian Pattaro @cpattaro.bsky.social · 12d

Congratulations Christina!

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George Davey Smith @mendelrandom.bsky.social · 18d

Galton calling for data sharing in 1901 - does anyone know of earlier examples?

Uku Vainik @ukuvainik.bsky.social · 18d

I know that Galton called out for sharing data in 1901

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Maria Bigoni @mbigoni.bsky.social · 18d

🚨 Job Market Alert 🚨

The Department of Economics of the University of Bologna invites applications for a fixed-term Assistant Professor position
**any field**
starting AY 2026/27.

📅 Apply by Nov 10

💼 6-year contract, low teaching load, no Italian required.

Info: econjobmarket.org/positions/11...

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Frank Harrell @f2harrell.bsky.social · 19d

Glad to see this! I’ve long preferred a single robust well thought-out model that includes terms for things we know we don’t know such as interactions and nonlinearity of predictor effects. Bayesian models use skeptical priors for complexities we hope we don’t need. #StatsSky

Joe Bak-Coleman @jbakcoleman.bsky.social · 20d

Great piece on the absurdity of brute force multiverse analyses.

www.pnas.org/doi/10.1073/...

Robustness is better assessed with a few thoughtful models than with billions of regressions | PNAS

Robustness is better assessed with a few thoughtful models than with billions of regressions

www.pnas.org

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Cristian Pattaro @cpattaro.bsky.social · 23d

Further evidence that race and ethnicity are social constructs: at the same level of genetic admixture, self-assigned race/ethnicity varies by ancestry, with age also playing a role in the self-classification process #popgen
onlinelibrary.wiley.com/doi/10.1002/...

The Complex Relationship of Genetic Ancestry With Self‐Reported Race/Ethnicity

Race and ethnicity are demographic constructs used to characterize individuals in biomedical research, and in particular to assess health disparities. Their use in medicine and research has been disc....

onlinelibrary.wiley.com

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Michael Friendly @datavisfriendly.bsky.social · 25d

#rstats #dataviz
Over 30 years ago, when I was doing graphics with #SAS, I imagined traveling in color space and computing meaningful palettes. I ranted that:

Every time you are forced to say “#008B8B” or “cyan4”
a puppy dies somewhere

Slide on "Software: Color specification"
WTF! Give me a break, please:
• Make it easier to compute with colors: define blends of colors or a color ramp
• Make it easier to specify color schemes with decent perceptual properties
• Make it easier to map colors to data features I want to show

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Cristian Pattaro @cpattaro.bsky.social · 25d

Another great paper and neat analysis from Andrea's group 👏

Andrea Ganna @andganna.bsky.social · 26d

🎉 New preprint out!

"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"

We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease

👉 doi.org/10.1101/2025...

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genomicsdoge.bsky.social @genomicsdoge.bsky.social · 26d

1/7 New BMI GWAS out! Using Estonian Biobank (n=204,747) and replication in FinnGen, we show that even in Europe you can still find region-specific biology if you zoom into population-tailored sumstats. Big thanks to co-author @kanwalbatool.bsky.social :)

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ASN Publications @asnpublications.bsky.social · 29d

In a new "Mechanisms of Kidney Disease" article in #ASNJASN, authors explore population studies and the genetic architecture of kidney diseases, highlighting a spectrum of risk. Read more: kidney.pub/JASN0893

@dannygale.bsky.social

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Frank Harrell @f2harrell.bsky.social · 29d

Briefly the two measures must already be perfectly transformed, there be no floor or ceiling effects, and difference must be unrelated to baseline. Details at hbiostat.org/bbr/change #Statistics #StatsSky

14 Transformations, Measuring Change, and Regression to the Mean – Biostatistics for Biomedical Research

hbiostat.org

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Nicholas Mancuso @nmancuso.bsky.social · Oct 10

5 YEARS of HGG Advances! Mike, Jessica, Sara, and so many others have done such a fantastic job in shaping and expanding the journal.

Please consider submitting your work in genetics/genomics with us!

Human Genetics and Genomics Advances @hggadvances.bsky.social · Oct 9

Our October issue is online!
Check out the amazing cover from @comfortandadam.bsky.social to commemorate 5 YEARS of HGG Advances!

www.cell.com/hgg-advances...

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Cristian Pattaro @cpattaro.bsky.social · Oct 10

"a polygenic score, by design, is acausal. It is a correlation accumulator"

Eric Turkheimer @ent3c.bsky.social · Aug 9

New blog post: The New Eugenics Companies
(Oops, I meant to say generational health and embryo selection)

The New Eugenics Companies

Oops, I meant to say generational health and embryo selection

ericturkheimer.substack.com

Cristian Pattaro @cpattaro.bsky.social · Oct 10

"dependence is the modal human condition"

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Cristian Pattaro @cpattaro.bsky.social · Oct 10

Thx for writing this. So deeply human.

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Cristian Pattaro @cpattaro.bsky.social · Oct 9

Agree. This struck me. Also thinking to the work reviewers have put on that.

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Cristian Pattaro @cpattaro.bsky.social · Oct 9

Massive #retraction of #Mendelianrandomization papers @ Skin Res Technol, >30 papers retracted in a single issue

Unclear biological rationale supporting valid application of MR to the research question 😶

Decision by journal+publisher. Authors disagree

onlinelibrary.wiley.com/toc/16000846...

Skin Research and Technology: Vol 31, No 10

Click on the title to browse this issue

onlinelibrary.wiley.com

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Tuuli Lappalainen @tuuliel.bsky.social · Oct 8

We're hiring! My team at @nygenome.org is looking for a statistical genetics postdoc to decipher functional architecture of complex diseases from cutting-edge CRISPR+scRNA-seq data, with @nevillesanjana.bsky.social lab. Happy to meet at #ASHG25, apply here
jobs.silkroad.com/NYGenome/Car...

Postdoctoral Research Associate, Lappalainen & Sanjana Labs - 101 Avenue of the Americas, 7th Floor, New York, New York - New York Genome Center

Find a career with New York Genome Center

jobs.silkroad.com

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Janne Pott @pottj.bsky.social · Oct 6

📣Preprint alert - a tricky one, as there are no significant results (and we all know null-results are hard to publish)
Do PCSK9 levels affect survival in breast cancer patients?
We tried to replicate findings in cell lines and mouse model using 3 Mendelian Randomization approaches, but failed.

medRxivpreprint @medrxivpreprint.bsky.social · Oct 5

PCSK9 and breast cancer survival: a Mendelian Randomization study https://www.medrxiv.org/content/10.1101/2025.10.03.25337270v1

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Cristian Pattaro @cpattaro.bsky.social · Oct 6

Towards race-free predictive formulas: a path that should not be abandoned

www.nejm.org/doi/full/10....

The Race-Correction Debates — Progress, Tensions, and Future Directions | NEJM

Many race-adjusted clinical tools have recently been scrutinized and replaced with race-neutral versions — efforts that have faced obstacles and generated contentious debate about the use of race i...

www.nejm.org

Cristian Pattaro @cpattaro.bsky.social · Oct 6

reflections on #sociogenomics

#popgen

www.cell.com/trends/genet...

A tale of two sociogenomics: shall the twain ever meet?

How does the social environment ‘get under the skin’ to influence the behavior of individual animals and humans and the activity of their genomes? And, conversely, how do genetic variants influence so...

www.cell.com

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Cristian Pattaro @cpattaro.bsky.social · Oct 5

Very nice application of factor analysis #stats

Simon Fisher @profsimonfisher.bsky.social · Oct 1

"Earlier- & later-diagnosed autism have different developmental trajectories & genetic profiles. The findings have important implications for how we conceptualize autism & provide a model to explain some of its diversity." @vw1234.bsky.social & an international team report today in @nature.com: 👇🧪

Polygenic and developmental profiles of autism differ by age at diagnosis - Nature

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

www.nature.com

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Mike Inouye @mikeinouye.bsky.social · Oct 3

Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research

and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!

Inouye Lab - Research

Background Technological advances have continued to drive the study of biology towards the statistical and computational sciences. We are now able to differentiate and quantify biomolecules at levels ...

www.inouyelab.org

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