Cristian Pattaro
@cpattaro.bsky.social
Biostatistics. Genetics. Epidemiology.
Group leader of Biostats & Epi @ Eurac Research
Group leader of Biostats & Epi @ Eurac Research
Reposted by Cristian Pattaro
“Promiscuous dichotomisation is yet another way of torturing the data to produce false confessions of which we must be eternally wary.”
#statistics #P-hacking #stats
#statistics #P-hacking #stats
November 13, 2025 at 11:29 PM
“Promiscuous dichotomisation is yet another way of torturing the data to produce false confessions of which we must be eternally wary.”
#statistics #P-hacking #stats
#statistics #P-hacking #stats
Reposted by Cristian Pattaro
Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders
rdcu.be/ePmwD
rdcu.be/ePmwD
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders
Nature Neuroscience - Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations....
rdcu.be
November 12, 2025 at 12:12 PM
Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders
rdcu.be/ePmwD
rdcu.be/ePmwD
Reposted by Cristian Pattaro
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Estimation and mapping of the missing heritability of human phenotypes - Nature
WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...
www.nature.com
November 12, 2025 at 5:57 PM
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Reposted by Cristian Pattaro
On “Confirmatory” Methodological Research in Statistics and Related Fields. F. J. D. Lange, Juliane C. Wilcke, Sabine Hoffmann, Moritz Herrmann, Anne-Laure Boulesteix. Statistics in Medicine. onlinelibrary.wiley.com/doi/10.1002/...
On “Confirmatory” Methodological Research in Statistics and Related Fields
Empirical substantive research, such as in the life or social sciences, is commonly categorized into the two modes exploratory and confirmatory, both of which are essential to scientific progress. Th...
onlinelibrary.wiley.com
November 11, 2025 at 5:54 PM
On “Confirmatory” Methodological Research in Statistics and Related Fields. F. J. D. Lange, Juliane C. Wilcke, Sabine Hoffmann, Moritz Herrmann, Anne-Laure Boulesteix. Statistics in Medicine. onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Cristian Pattaro
Is It Time to Consider Population-Based Urine Dipstick Screening for Early Detection of Kidney Disease? ca. 2025 from @kireports.bsky.social @saynanorouzi.bsky.social
#Nephpearls #KidneyWk #NephSky
👉 www.kireports.org/article/S246...
#Nephpearls #KidneyWk #NephSky
👉 www.kireports.org/article/S246...
November 7, 2025 at 2:58 PM
Is It Time to Consider Population-Based Urine Dipstick Screening for Early Detection of Kidney Disease? ca. 2025 from @kireports.bsky.social @saynanorouzi.bsky.social
#Nephpearls #KidneyWk #NephSky
👉 www.kireports.org/article/S246...
#Nephpearls #KidneyWk #NephSky
👉 www.kireports.org/article/S246...
Reposted by Cristian Pattaro
I am deeply honored to have been awarded the European Hormone Medal 2026!
We are delighted to announce the winners of the ESE Awards for 2026.🏆
🎉Congratulations to our exceptional winners who have made huge contributions in the field of #endocrinology and will present at #ECE2026 in Prague, Czech Republic from 9-12 May 2026.
Find out more👉 ow.ly/ITyL50XjEWm
🎉Congratulations to our exceptional winners who have made huge contributions in the field of #endocrinology and will present at #ECE2026 in Prague, Czech Republic from 9-12 May 2026.
Find out more👉 ow.ly/ITyL50XjEWm
October 30, 2025 at 8:48 AM
I am deeply honored to have been awarded the European Hormone Medal 2026!
Reposted by Cristian Pattaro
Galton calling for data sharing in 1901 - does anyone know of earlier examples?
October 24, 2025 at 8:43 PM
Galton calling for data sharing in 1901 - does anyone know of earlier examples?
Reposted by Cristian Pattaro
🚨 Job Market Alert 🚨
The Department of Economics of the University of Bologna invites applications for a fixed-term Assistant Professor position
**any field**
starting AY 2026/27.
📅 Apply by Nov 10
💼 6-year contract, low teaching load, no Italian required.
Info: econjobmarket.org/positions/11...
The Department of Economics of the University of Bologna invites applications for a fixed-term Assistant Professor position
**any field**
starting AY 2026/27.
📅 Apply by Nov 10
💼 6-year contract, low teaching load, no Italian required.
Info: econjobmarket.org/positions/11...
October 24, 2025 at 8:30 PM
🚨 Job Market Alert 🚨
The Department of Economics of the University of Bologna invites applications for a fixed-term Assistant Professor position
**any field**
starting AY 2026/27.
📅 Apply by Nov 10
💼 6-year contract, low teaching load, no Italian required.
Info: econjobmarket.org/positions/11...
The Department of Economics of the University of Bologna invites applications for a fixed-term Assistant Professor position
**any field**
starting AY 2026/27.
📅 Apply by Nov 10
💼 6-year contract, low teaching load, no Italian required.
Info: econjobmarket.org/positions/11...
Reposted by Cristian Pattaro
Glad to see this! I’ve long preferred a single robust well thought-out model that includes terms for things we know we don’t know such as interactions and nonlinearity of predictor effects. Bayesian models use skeptical priors for complexities we hope we don’t need. #StatsSky
October 23, 2025 at 11:50 AM
Glad to see this! I’ve long preferred a single robust well thought-out model that includes terms for things we know we don’t know such as interactions and nonlinearity of predictor effects. Bayesian models use skeptical priors for complexities we hope we don’t need. #StatsSky
Further evidence that race and ethnicity are social constructs: at the same level of genetic admixture, self-assigned race/ethnicity varies by ancestry, with age also playing a role in the self-classification process #popgen
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
The Complex Relationship of Genetic Ancestry With Self‐Reported Race/Ethnicity
Race and ethnicity are demographic constructs used to characterize individuals in biomedical research, and in particular to assess health disparities. Their use in medicine and research has been disc....
onlinelibrary.wiley.com
October 20, 2025 at 7:40 AM
Further evidence that race and ethnicity are social constructs: at the same level of genetic admixture, self-assigned race/ethnicity varies by ancestry, with age also playing a role in the self-classification process #popgen
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Another great paper and neat analysis from Andrea's group 👏
🎉 New preprint out!
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
October 17, 2025 at 10:57 AM
Another great paper and neat analysis from Andrea's group 👏
Reposted by Cristian Pattaro
1/7 New BMI GWAS out! Using Estonian Biobank (n=204,747) and replication in FinnGen, we show that even in Europe you can still find region-specific biology if you zoom into population-tailored sumstats. Big thanks to co-author @kanwalbatool.bsky.social :)
October 16, 2025 at 6:54 PM
1/7 New BMI GWAS out! Using Estonian Biobank (n=204,747) and replication in FinnGen, we show that even in Europe you can still find region-specific biology if you zoom into population-tailored sumstats. Big thanks to co-author @kanwalbatool.bsky.social :)
Reposted by Cristian Pattaro
In a new "Mechanisms of Kidney Disease" article in #ASNJASN, authors explore population studies and the genetic architecture of kidney diseases, highlighting a spectrum of risk. Read more: kidney.pub/JASN0893
@dannygale.bsky.social
@dannygale.bsky.social
October 13, 2025 at 8:00 PM
In a new "Mechanisms of Kidney Disease" article in #ASNJASN, authors explore population studies and the genetic architecture of kidney diseases, highlighting a spectrum of risk. Read more: kidney.pub/JASN0893
@dannygale.bsky.social
@dannygale.bsky.social
Reposted by Cristian Pattaro
Briefly the two measures must already be perfectly transformed, there be no floor or ceiling effects, and difference must be unrelated to baseline. Details at hbiostat.org/bbr/change #Statistics #StatsSky
14 Transformations, Measuring Change, and Regression to the Mean – Biostatistics for Biomedical Research
hbiostat.org
October 13, 2025 at 1:25 PM
Briefly the two measures must already be perfectly transformed, there be no floor or ceiling effects, and difference must be unrelated to baseline. Details at hbiostat.org/bbr/change #Statistics #StatsSky
Reposted by Cristian Pattaro
5 YEARS of HGG Advances! Mike, Jessica, Sara, and so many others have done such a fantastic job in shaping and expanding the journal.
Please consider submitting your work in genetics/genomics with us!
Please consider submitting your work in genetics/genomics with us!
Our October issue is online!
Check out the amazing cover from @comfortandadam.bsky.social to commemorate 5 YEARS of HGG Advances!
www.cell.com/hgg-advances...
Check out the amazing cover from @comfortandadam.bsky.social to commemorate 5 YEARS of HGG Advances!
www.cell.com/hgg-advances...
October 10, 2025 at 4:10 PM
5 YEARS of HGG Advances! Mike, Jessica, Sara, and so many others have done such a fantastic job in shaping and expanding the journal.
Please consider submitting your work in genetics/genomics with us!
Please consider submitting your work in genetics/genomics with us!
"a polygenic score, by design, is acausal. It is a correlation accumulator"
New blog post: The New Eugenics Companies
(Oops, I meant to say generational health and embryo selection)
(Oops, I meant to say generational health and embryo selection)
The New Eugenics Companies
Oops, I meant to say generational health and embryo selection
ericturkheimer.substack.com
October 10, 2025 at 3:38 PM
"a polygenic score, by design, is acausal. It is a correlation accumulator"
"dependence is the modal human condition"
October 10, 2025 at 3:13 PM
"dependence is the modal human condition"
Massive #retraction of #Mendelianrandomization papers @ Skin Res Technol, >30 papers retracted in a single issue
Unclear biological rationale supporting valid application of MR to the research question 😶
Decision by journal+publisher. Authors disagree
onlinelibrary.wiley.com/toc/16000846...
Unclear biological rationale supporting valid application of MR to the research question 😶
Decision by journal+publisher. Authors disagree
onlinelibrary.wiley.com/toc/16000846...
Skin Research and Technology: Vol 31, No 10
Click on the title to browse this issue
onlinelibrary.wiley.com
October 9, 2025 at 2:01 PM
Massive #retraction of #Mendelianrandomization papers @ Skin Res Technol, >30 papers retracted in a single issue
Unclear biological rationale supporting valid application of MR to the research question 😶
Decision by journal+publisher. Authors disagree
onlinelibrary.wiley.com/toc/16000846...
Unclear biological rationale supporting valid application of MR to the research question 😶
Decision by journal+publisher. Authors disagree
onlinelibrary.wiley.com/toc/16000846...
Reposted by Cristian Pattaro
We're hiring! My team at @nygenome.org is looking for a statistical genetics postdoc to decipher functional architecture of complex diseases from cutting-edge CRISPR+scRNA-seq data, with @nevillesanjana.bsky.social lab. Happy to meet at #ASHG25, apply here
jobs.silkroad.com/NYGenome/Car...
jobs.silkroad.com/NYGenome/Car...
Postdoctoral Research Associate, Lappalainen & Sanjana Labs - 101 Avenue of the Americas, 7th Floor, New York, New York - New York Genome Center
Find a career with New York Genome Center
jobs.silkroad.com
October 8, 2025 at 2:41 PM
We're hiring! My team at @nygenome.org is looking for a statistical genetics postdoc to decipher functional architecture of complex diseases from cutting-edge CRISPR+scRNA-seq data, with @nevillesanjana.bsky.social lab. Happy to meet at #ASHG25, apply here
jobs.silkroad.com/NYGenome/Car...
jobs.silkroad.com/NYGenome/Car...
Reposted by Cristian Pattaro
📣Preprint alert - a tricky one, as there are no significant results (and we all know null-results are hard to publish)
Do PCSK9 levels affect survival in breast cancer patients?
We tried to replicate findings in cell lines and mouse model using 3 Mendelian Randomization approaches, but failed.
Do PCSK9 levels affect survival in breast cancer patients?
We tried to replicate findings in cell lines and mouse model using 3 Mendelian Randomization approaches, but failed.
PCSK9 and breast cancer survival: a Mendelian Randomization study https://www.medrxiv.org/content/10.1101/2025.10.03.25337270v1
October 6, 2025 at 4:50 PM
📣Preprint alert - a tricky one, as there are no significant results (and we all know null-results are hard to publish)
Do PCSK9 levels affect survival in breast cancer patients?
We tried to replicate findings in cell lines and mouse model using 3 Mendelian Randomization approaches, but failed.
Do PCSK9 levels affect survival in breast cancer patients?
We tried to replicate findings in cell lines and mouse model using 3 Mendelian Randomization approaches, but failed.
Towards race-free predictive formulas: a path that should not be abandoned
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
The Race-Correction Debates — Progress, Tensions, and Future Directions | NEJM
Many race-adjusted clinical tools have recently been scrutinized and replaced with
race-neutral versions — efforts that have faced obstacles and generated contentious
debate about the use of race i...
www.nejm.org
October 6, 2025 at 7:53 PM
Towards race-free predictive formulas: a path that should not be abandoned
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Very nice application of factor analysis #stats
"Earlier- & later-diagnosed autism have different developmental trajectories & genetic profiles. The findings have important implications for how we conceptualize autism & provide a model to explain some of its diversity." @vw1234.bsky.social & an international team report today in @nature.com: 👇🧪
Polygenic and developmental profiles of autism differ by age at diagnosis - Nature
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
www.nature.com
October 5, 2025 at 7:53 PM
Very nice application of factor analysis #stats
Reposted by Cristian Pattaro
Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research
and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!
and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!
Inouye Lab - Research
Background
Technological advances have continued to drive the study of biology towards the statistical and computational sciences. We are now able to differentiate and quantify biomolecules at levels ...
www.inouyelab.org
October 3, 2025 at 7:54 PM
Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research
and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!
and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!