Cell Metabolism
@cp-cellmetabolism.bsky.social
A Cell Press journal publishing cutting-edge research in metabolism biology, from molecular/cellular biology to translational and clinical studies.
Online now: From microbiome to metabolism: Bridging a two-decade translational gap
From microbiome to metabolism: Bridging a two-decade translational gap
Despite their initial promise, microbiome-based therapies face translational challenges. This perspective examines the limitations of correlative studies; the mechanistic insights from animal models; and the need for precision, functional profiling, and AI-driven multi-omics to realize personalized, systems-level interventions in metabolic disease.
dlvr.it
November 13, 2025 at 4:42 PM
Online now: From microbiome to metabolism: Bridging a two-decade translational gap
Online now: Therapeutic remodeling of the ceramide backbone prevents kidney injury
Therapeutic remodeling of the ceramide backbone prevents kidney injury
Nicholson et al. uncover a ceramide-driven mechanism of mitochondrial injury in acute kidney injury (AKI). By targeting the ceramide-producing enzyme DES1, they preserve kidney function and identify a promising therapeutic strategy. These findings link lipid metabolism to mitochondrial dysfunction and suggest new avenues for preventing tissue damage in AKI.
dlvr.it
November 12, 2025 at 4:42 PM
Online now: Therapeutic remodeling of the ceramide backbone prevents kidney injury
Online now: Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis
The exact mechanisms underlying leptin resistance remain elusive. Here, Wang et al. report that adipocyte-derived EVs and their miRNA cargo are key regulators of central leptin sensitivity and that the loss of these leptin-sensitizing miRNAs in adipocyte EVs contributes to leptin resistance and obesity.
dlvr.it
November 11, 2025 at 4:42 PM
Online now: Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis
Online now: Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid
Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid
(Cell Metabolism 37, 1998–2013.e1–e7; October 7, 2025)
dlvr.it
November 6, 2025 at 4:42 PM
Online now: Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid
Online now: Dietary fat disrupts a commensal-host lipid network that promotes metabolic health
Dietary fat disrupts a commensal-host lipid network that promotes metabolic health
Klag et al. identified that Turicibacter, a spore-forming bacteria, promotes leanness by producing unique lipids that suppress host ceramides and reduce fat uptake. High-fat diets lower Turicibacter levels and its protective effects, but supplementation with Turicibacter or Turicibacter lipids prevents obesity, revealing a therapeutic lipid metabolic circuit between bacteria and host.
dlvr.it
November 6, 2025 at 1:40 PM
Online now: Dietary fat disrupts a commensal-host lipid network that promotes metabolic health
Online now: Lighting up arginine metabolism reveals its functional diversity in physiology and pathology
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology
(Cell Metabolism 37, 291–304.e1–e9; January 7, 2025)
dlvr.it
November 5, 2025 at 7:50 PM
Online now: Lighting up arginine metabolism reveals its functional diversity in physiology and pathology
Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
(Cell Metabolism 37, 1460–1481.e1–e17; July 1, 2025)
dlvr.it
November 5, 2025 at 4:42 PM
Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
Online now: 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
(Cell Metabolism 30, 768–783.e1–e7; October 1, 2019)
dlvr.it
November 5, 2025 at 1:40 PM
Online now: 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
Online now: Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation
Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation
Drekolia, Mettner, Wang et al. identified a nuclear metabolic pathway—triggered before cell division—that burns cystine to regulate the epigenome, unlock chromatin, and prime endothelial gene programs. This nutrient-responsive epigenetic circuit wanes with age, yet dietary cystine revives endothelial transcription and restores vessel growth in injury, disease, and aging.
dlvr.it
October 31, 2025 at 3:43 PM
Online now: Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation
Online now: Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer
Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer
Zhengwei et al. show that lung tumor-initiating cells (TICs) adapt to glucose limitation by switching to ketone utilization, dependent on MCT1 and its chaperone CD147. The ketogenic diet expands the TIC pool yet, paradoxically, induces vulnerability toward MCT1 inhibition, demonstrating how dietary intervention may be exploited to enhance anti-cancer therapies.
dlvr.it
October 24, 2025 at 6:50 PM
Online now: Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer
Online now: Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
DOPAC, a microbial metabolite of quercetin, enhances CD8+ T cell-mediated anti-tumor immunity by activating NRF2-driven mitophagy, thereby improving T cell fitness and potentiating the response to immune checkpoint blockade.
dlvr.it
October 24, 2025 at 3:42 PM
Online now: Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
Online now: Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Dufau, Recazens, et al. identified the neutral lipase HSL in the nucleus of adipocytes, where it modulates gene expression. The trafficking of HSL between the nucleus and the cytosol is under the control of TGF-β and catecholamine signaling. In vivo, the presence of nuclear HSL is crucial for adipose tissue development.
dlvr.it
October 23, 2025 at 6:50 PM
Online now: Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Online now: Dietary urbanization destabilizes host-gut microbiome homeostasis and informs precision nutrition for human health
Dietary urbanization destabilizes host-gut microbiome homeostasis and informs precision nutrition for human health
Dietary urbanization has reshaped the human gut microbiota relating to the rising non-communicable diseases. Zhang et al. deconvolute the impacts of urban diets on the gut microbiome leading to non-communicable diseases and propose a microbiome-directed precision-nutrition framework to combat diseases.
dlvr.it
October 23, 2025 at 3:42 PM
Online now: Dietary urbanization destabilizes host-gut microbiome homeostasis and informs precision nutrition for human health
Online now: Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling
Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling
Tai et al. employed mouse models of skin injury to demonstrate that injury-induced panniculitis stimulates hair regeneration by promoting adipocyte lipolysis via macrophage-adipocyte interactions. This process subsequently activates eHFSCs through the released unsaturated fatty acids, which serve as essential signaling mediators and fuels that promote eHFSC activation.
dlvr.it
October 22, 2025 at 6:50 PM
Online now: Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling
Online now: The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα
The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα
Xie et al. demonstrate that 326E, an enedioic acid analog, safely and effectively reverses MASH in multiple preclinical models by dually inhibiting ACLY and activating PPARα, with early clinical trials showing good tolerance and potential for further development.
dlvr.it
October 22, 2025 at 3:42 PM
Online now: The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα
Online now: Aged mice exhibit widespread metabolic changes but preserved major fluxes
Aged mice exhibit widespread metabolic changes but preserved major fluxes
Metabolic dysregulation is a hallmark of aging, but how metabolic pathway activity (flux) changes with age has yet to be broadly assessed. Here, Jankowski et al. measure metabolite concentrations and fluxes in aged mice, finding that major metabolic fluxes are remarkably well preserved with age despite widespread concentration changes.
dlvr.it
October 16, 2025 at 3:42 PM
Online now: Aged mice exhibit widespread metabolic changes but preserved major fluxes
Online now: Nutrient allocation fuels T cell-mediated immunity
Nutrient allocation fuels T cell-mediated immunity
Glucose has traditionally been considered the primary fuel for T cells. Longo et al. present evidence for a revised, “nutrient allocation” model, in which effector T cells channel diverse nutrient sources into specific metabolic pathways to fuel T cell-mediated immunity.
dlvr.it
October 15, 2025 at 3:42 PM
Online now: Nutrient allocation fuels T cell-mediated immunity
Online now: Galnt2 neurons in the ventromedial hypothalamus counterregulate hypoglycemia via a brain-liver neurocircuit
Galnt2 neurons in the ventromedial hypothalamus counterregulate hypoglycemia via a brain-liver neurocircuit
Wang et al. reveal a biphasic counterregulatory response to hypoglycemia mediated by a threshold-dependent brain-liver neurocircuit that directly senses neuroglycopenia. Within this pathway, Galnt2 acts as a molecular brake in ventromedial hypothalamic glucose-inhibited neurons, tuning their glucose perception and modulating hepatic glucose production.
dlvr.it
October 14, 2025 at 3:42 PM
Online now: Galnt2 neurons in the ventromedial hypothalamus counterregulate hypoglycemia via a brain-liver neurocircuit
Online now: Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial import of methylated amino acids and carnitine synthesis. Loss of Slc25a45 impairs fasting response by limiting carnitine availability for β-oxidation.
dlvr.it
October 10, 2025 at 3:43 PM
Online now: Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Online now: An “electric” microbial cue to control food intake behavior
An “electric” microbial cue to control food intake behavior
The gut conveys nutritional, mechanical, and microbial signals to the brain to regulate physiology and behavior. Writing in Nature, Liu et al. reveal a colonic neuropod-vagus circuit that senses bacterial flagellin, highlighting microbial input as a rapid driver of feeding control and expanding paradigms of communication between the gut and the brain.
dlvr.it
October 7, 2025 at 6:50 PM
Online now: An “electric” microbial cue to control food intake behavior
Online now: AMPKα2 signals amino acid insufficiency to inhibit protein synthesis
AMPKα2 signals amino acid insufficiency to inhibit protein synthesis
Two homologous catalytic subunits, AMPKα1 and AMPKα2, exist in AMPK complexes. Mao et al. find that AMPKα2 specifically responds to amino acid insufficiency to inhibit protein translation. Loss of AMPKα2 causes increased protein synthesis and induces Alzheimer’s disease (AD)-like symptoms in mice, whereas amino acid restriction or AMPK activation α2-dependently prevents these symptoms.
dlvr.it
October 7, 2025 at 3:42 PM
Online now: AMPKα2 signals amino acid insufficiency to inhibit protein synthesis
Online now: Paternal exercise confers endurance capacity to offspring through sperm microRNAs
Paternal exercise confers endurance capacity to offspring through sperm microRNAs
Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic health via sperm microRNAs that reprogram gene expression in early embryos, revealing how exercise benefits can be inherited across generations.
dlvr.it
October 6, 2025 at 6:50 PM
Online now: Paternal exercise confers endurance capacity to offspring through sperm microRNAs
Online now: The energy resistance principle
The energy resistance principle
Picard and Murugan introduce the energy resistance principle (ERP), a testable framework outlining how resistance to energy flow sustains life and shapes health. Excess resistance (éR) promotes hallmarks of disease, whereas restorative states minimize éR, thus linking the biophysics of energy to human health, aging, and healing.
dlvr.it
October 6, 2025 at 3:42 PM
Online now: The energy resistance principle
Online now: Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid
Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid
Zhang et al. reveal that the gut bacterium Catenibacterium mitsuokai promotes hepatocellular carcinoma by disrupting the gut barrier, colonizing HCC cells via its surface protein Gtr1/RagA and receptor γ-catenin, and secreting quinolinic acid, which binds to TIE2 and activates the oncogenic PI3K/AKT pathway in HCC cells.
dlvr.it
September 25, 2025 at 3:42 PM
Online now: Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid
Online now: Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression
Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression
Li et al. demonstrate that fatty livers foster a favorable metabolic landscape for breast cancer via adipocyte-oriented exosomes. These exosomes display tropism to mammary adipocytes through the ErbB4-Nrg4 axis. Exosomal TRMT10C triggers adipocyte ROS production, boosts IL-6 secretion, and subsequently enhances free fatty acid release, thereby facilitating tumor initiation and growth.
dlvr.it
September 24, 2025 at 3:42 PM
Online now: Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression