ComplexPortal
@complexportal.bsky.social
The Complex Portal is an encyclopaedic resource of macromolecular complexes from a number of key model organisms.
http://www.ebi.ac.uk/complexportal
Also follow➡️@intact-ebi.bsky.social
http://www.ebi.ac.uk/complexportal
Also follow➡️@intact-ebi.bsky.social
Want your PPI or structural data to make an impact?
✅ Use Identifierss
✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713)
✅ Submit to EMBL-EBI's data resources - IntAct
👉 See Niri’s dataset in IntAct:
tinyurl.com/yp8ddheh
✅ Use Identifierss
✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713)
✅ Submit to EMBL-EBI's data resources - IntAct
👉 See Niri’s dataset in IntAct:
tinyurl.com/yp8ddheh
October 19, 2025 at 1:25 PM
Want your PPI or structural data to make an impact?
✅ Use Identifierss
✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713)
✅ Submit to EMBL-EBI's data resources - IntAct
👉 See Niri’s dataset in IntAct:
tinyurl.com/yp8ddheh
✅ Use Identifierss
✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713)
✅ Submit to EMBL-EBI's data resources - IntAct
👉 See Niri’s dataset in IntAct:
tinyurl.com/yp8ddheh
🧬 On #GlobalPNHAwarenessDay, we spotlight the GPI-GnT complex - a key enzyme disrupted in PNH, a rare and life-threatening blood disorder.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
October 12, 2025 at 1:44 PM
🧬 On #GlobalPNHAwarenessDay, we spotlight the GPI-GnT complex - a key enzyme disrupted in PNH, a rare and life-threatening blood disorder.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
See also @wojtekgalej.bsky.social and
tinyurl.com/3sfthabb
#MinorSpliceosome #RNAsplicing #snRNP #U12Introns
tinyurl.com/3sfthabb
#MinorSpliceosome #RNAsplicing #snRNP #U12Introns
October 1, 2025 at 8:27 AM
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
September 22, 2025 at 10:31 AM
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
🧠 Ever wonder how your tongue detects umami or sweetness?
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
August 28, 2025 at 2:24 PM
🧠 Ever wonder how your tongue detects umami or sweetness?
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
🐍 From Dark Myths to Eco Allies: Celebrating #WorldSnakeDay
Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins.
🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)
Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins.
🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)
July 17, 2025 at 9:50 AM
🐍 From Dark Myths to Eco Allies: Celebrating #WorldSnakeDay
Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins.
🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)
Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins.
🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)
Intronic repeats play big roles evolution, gene regulation & disease. They're linked to disorders like Haemophilia & cancer. Cells keep them in check through RNAi-driven heterochromatin formation. See the S. pombe CLR4 complex (CPX-9241) & learn about its involvement in transcriptional silencing.
July 2, 2025 at 4:05 PM
Intronic repeats play big roles evolution, gene regulation & disease. They're linked to disorders like Haemophilia & cancer. Cells keep them in check through RNAi-driven heterochromatin formation. See the S. pombe CLR4 complex (CPX-9241) & learn about its involvement in transcriptional silencing.
Do you want to learn more about macromolecular complexes? Register for our webinar taking place on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! 📅
🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC).
➡️ Register now:
tinyurl.com/bdy6wttv
🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC).
➡️ Register now:
tinyurl.com/bdy6wttv
June 27, 2025 at 2:23 PM
Do you want to learn more about macromolecular complexes? Register for our webinar taking place on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! 📅
🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC).
➡️ Register now:
tinyurl.com/bdy6wttv
🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC).
➡️ Register now:
tinyurl.com/bdy6wttv
This month features CUL4A (Q13619). Cullin4-RING E3 ubiquitin ligases (CRL4s) regulate processes including facilitating stalled fork stability & genome integrity. Search the CP using GO:0080008 (tinyurl.com/2zhsy43s) & use the Navigator to explore our range of CRL4 complexes! #MolBiol, #ubiquitin
June 3, 2025 at 9:28 AM
This month features CUL4A (Q13619). Cullin4-RING E3 ubiquitin ligases (CRL4s) regulate processes including facilitating stalled fork stability & genome integrity. Search the CP using GO:0080008 (tinyurl.com/2zhsy43s) & use the Navigator to explore our range of CRL4 complexes! #MolBiol, #ubiquitin
May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). ComplexPortal: tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-linked proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #ComplexPortal, #IntAct-EBI, #UniProt
May 21, 2025 at 9:44 AM
May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). ComplexPortal: tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-linked proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #ComplexPortal, #IntAct-EBI, #UniProt
We're excited to promote our range of Dynactin & Dynein complexes this month! Visit the Complex Portal to explore the respective orthologous and paralogous complexes! (ebi.ac.uk/complexporta...) #Dynactin, #Dynein, #Intracellulartransport
May 2, 2025 at 10:31 AM
We're excited to promote our range of Dynactin & Dynein complexes this month! Visit the Complex Portal to explore the respective orthologous and paralogous complexes! (ebi.ac.uk/complexporta...) #Dynactin, #Dynein, #Intracellulartransport
Hello Spliceosome enthusiasts! Explore the Spliceosome's catalytic activity on pre-mRNA through a highly dynamic series of compositional states. Visit the CP & use the Navigator tool to compare human Major Spliceosome complexes from various points in their lifecycle (tinyurl.com/yy4fbcp2).
April 11, 2025 at 9:59 AM
Hello Spliceosome enthusiasts! Explore the Spliceosome's catalytic activity on pre-mRNA through a highly dynamic series of compositional states. Visit the CP & use the Navigator tool to compare human Major Spliceosome complexes from various points in their lifecycle (tinyurl.com/yy4fbcp2).
Complex Portal release 250 is out! 5,049 manually curated biological complexes. www.ebi.ac.uk/complexportal (in sync with UniProt release 2025_02). Come explore our high quality manually-curated complexes!!
April 10, 2025 at 4:55 PM
Complex Portal release 250 is out! 5,049 manually curated biological complexes. www.ebi.ac.uk/complexportal (in sync with UniProt release 2025_02). Come explore our high quality manually-curated complexes!!
Interested in RASopathy and RAS-driven cancers? This month we feature SHOC-MRAS holophosphatase complexes.....CPX-25716, CPX-25719, CPX-25720. Visit the Complex Portal (www.ebi.ac.uk/complexporta...) to learn more!
March 4, 2025 at 9:45 AM
Interested in RASopathy and RAS-driven cancers? This month we feature SHOC-MRAS holophosphatase complexes.....CPX-25716, CPX-25719, CPX-25720. Visit the Complex Portal (www.ebi.ac.uk/complexporta...) to learn more!
👩🔬 Today is International Women and Girls in Science day! 🧪 To celebrate we’re shining the spotlight on two biocurators at the Complex Portal.
February 12, 2025 at 9:30 AM
👩🔬 Today is International Women and Girls in Science day! 🧪 To celebrate we’re shining the spotlight on two biocurators at the Complex Portal.
👩🔬 Today is International Women and Girls in Science day! 🧪 To celebrate we’re shining the spotlight on two biocurators at the Complex Portal.
February 12, 2025 at 9:29 AM
👩🔬 Today is International Women and Girls in Science day! 🧪 To celebrate we’re shining the spotlight on two biocurators at the Complex Portal.
Start 2025 with a look at the Prefoldin-like co-chaperone complex (tinyurl.com/3p8b2arh), it’s multi-functional with roles in proteostasis, protein folding, assembly and stabilization. Visit us to learn more about this and Prefoldin (CPX-6149) & PAQosome (CPX-6145) complexes!
January 31, 2025 at 2:07 PM
Start 2025 with a look at the Prefoldin-like co-chaperone complex (tinyurl.com/3p8b2arh), it’s multi-functional with roles in proteostasis, protein folding, assembly and stabilization. Visit us to learn more about this and Prefoldin (CPX-6149) & PAQosome (CPX-6145) complexes!
Want to learn more about our expanded coverage of human complexes, new tools and our new User Interface....come take a Quick Tour!!! www.ebi.ac.uk/training/onl...
January 29, 2025 at 4:00 PM
Want to learn more about our expanded coverage of human complexes, new tools and our new User Interface....come take a Quick Tour!!! www.ebi.ac.uk/training/onl...
Expertly curated context-specific complexes based on combinatorial experimental and computational approaches from PMID:36179048 (www.pnas.org/doi/full/10....). See Complex Portal for CPX-8828 and related TNF complexes (www.ebi.ac.uk/complexporta...).
January 2, 2025 at 12:30 PM
Expertly curated context-specific complexes based on combinatorial experimental and computational approaches from PMID:36179048 (www.pnas.org/doi/full/10....). See Complex Portal for CPX-8828 and related TNF complexes (www.ebi.ac.uk/complexporta...).
The Complex Portal is now on LinkedIn....come follow us!
December 12, 2024 at 2:39 PM
The Complex Portal is now on LinkedIn....come follow us!
Excited to announce the addition of MuSIC (www.nature.com/articles/s41...) complexes in our latest release of the Complex Portal! Visit the Complex Portal (www.ebi.ac.uk/complexporta...) to learn more….
December 10, 2024 at 11:25 AM
Excited to announce the addition of MuSIC (www.nature.com/articles/s41...) complexes in our latest release of the Complex Portal! Visit the Complex Portal (www.ebi.ac.uk/complexporta...) to learn more….
A focus on the Myddosome core complex (www.ebi.ac.uk/complexporta...), an innate immune signalling platform which transmits inflammatory signals as a result of TLR/IL1R activation. Search the Complex Portal to find complexes involved in inflammatory responses (www.ebi.ac.uk/complexporta...)
December 3, 2024 at 11:00 AM
A focus on the Myddosome core complex (www.ebi.ac.uk/complexporta...), an innate immune signalling platform which transmits inflammatory signals as a result of TLR/IL1R activation. Search the Complex Portal to find complexes involved in inflammatory responses (www.ebi.ac.uk/complexporta...)
Very excited to share our latest NAR publication (academic.oup.com/nar/advance-...) describing the addition of predicted complexes from Hu.Map3.0..@kdrew
..and updated features to our User interface
..and updated features to our User interface
December 3, 2024 at 10:53 AM
Very excited to share our latest NAR publication (academic.oup.com/nar/advance-...) describing the addition of predicted complexes from Hu.Map3.0..@kdrew
..and updated features to our User interface
..and updated features to our User interface
Our #CotM on #InternationalWomensDay #IWD2021 celebrates @KowaEva's team @EMBL for solving the @yeastgenome cytoplasmic exosome complex:The cytoplasmic exosome is a 3' to 5' exo- and endoribonuclease that is involved in RNA maturation & degradation
ebi.ac.uk/complexportal/…
ebi.ac.uk/complexportal/…
December 3, 2024 at 10:42 AM
Our #CotM on #InternationalWomensDay #IWD2021 celebrates @KowaEva's team @EMBL for solving the @yeastgenome cytoplasmic exosome complex:The cytoplasmic exosome is a 3' to 5' exo- and endoribonuclease that is involved in RNA maturation & degradation
ebi.ac.uk/complexportal/…
ebi.ac.uk/complexportal/…