Pairs with these sorts of regulatory relationships are enriched in synthetic lethality – when one gene gets deleted, cells become dependent on the other for survival – suggesting these relationships can identify new therapeutic targets. The cartoon below illustrates the proposed model.

Congrats to Anjan Venkatesh, who passed his viva @ucddublin.bsky.social this morning. Thanks to extern @pedrobeltrao.bsky.social, intern Denis Shields and chair Dimitris Chatzopoulos. cc @ucddublin.bsky.social @ucdcs.bsky.social

We will be hosting the International Conference on Systems Biology (ICSB) in Dublin this year – 5-9th October icsb2025.com/registration/ #ICSB2025

this table evaluates the methods on an actual combinatorial screen where we have data on both the identified SL pairs and the set of screened pairs (real negatives instead of random sampling!). in this case, all methods perform significantly worse than the analyses presented elsewhere in the paper.